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MOUSE:HAP1

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0048471

perinuclear region of cytoplasm

PMID:21985783

ECO:0000314

C

Figure 1

complete
CACAO 2335

public

GO:2000766

negative regulation of cytoplasmic translation

PMID:21985783

ECO:0000315

P

fig. 4

complete
CACAO 2338

public

GO:0006917

induction of apoptosis

PMID:21985783

ECO:0000314

P

fig. 6

complete
CACAO 2339

public

GO:0005813

centrosome

PMID:21985783

ECO:0000314

C

Figure1

complete
CACAO 2444

public

GO:2000154

negative regulation of flagellar cell motility

PMID:21985783

ECO:0000314

P

Figure 5: PolyQ-Htt accumulates PCM1 at centrosome and increases cilia length.

complete
CACAO 2455

public

GO:0022008

neurogenesis

PMID:18636121

ECO:0000315

P

Supplemental Figure 4 (b): We observed a significant reduction in the number of BrdU-positive cells in the absence of Hap1.

complete
CACAO 2788

public

GO:0021549

cerebellum development

PMID:18636121

ECO:0000315

P

Figure 5A: There was a reduction in the size of cerebellar folia in Hap1-null mice compared with littermate controls.

complete
CACAO 2789

public

GO:0001934

positive regulation of protein phosphorylation

PMID:18636121

ECO:0000314

P

Suppressing Hap1 expression by siRNA also reduced the level of phosphorylated Erk and Akt (Figure 7 C). Quantification of the ratio of phosphorylated Erk or Akt to the total amount of Erk and Akt confirmed the decreased phosphorylation of these proteins (Figure 7D).

complete

public

GO:0001920

negative regulation of receptor recycling

PMID:18636121

ECO:0000314

P

Figure 6 (B): of the relative levels of TrkB (the ratio of TrkB to tubulin) confirmed the decreased levels of TrkB in Hap1-KO mouse brains.

complete

protected

part_of

GO:0005813

centrosome

PMID:21985783

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0021549

cerebellum development

PMID:18636121

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0022008

neurogenesis

PMID:18636121

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0048403

brain-derived neurotrophic factor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54256

F

Seeded From UniProt

complete

protected

enables

GO:0044325

ion channel binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54256

F

Seeded From UniProt

complete

protected

involved_in

GO:1902430

negative regulation of amyloid-beta formation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54256

P

Seeded From UniProt

complete

protected

involved_in

GO:0045742

positive regulation of epidermal growth factor receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54256

P

Seeded From UniProt

complete

protected

involved_in

GO:0032901

positive regulation of neurotrophin production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54256

P

Seeded From UniProt

complete

protected

involved_in

GO:0032230

positive regulation of synaptic transmission, GABAergic

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54256

P

Seeded From UniProt

complete

protected

involved_in

GO:0031587

positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54256

P

Seeded From UniProt

complete

protected

involved_in

GO:0008090

retrograde axonal transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54256

P

Seeded From UniProt

complete

protected

involved_in

GO:0008089

anterograde axonal transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P54256

P

Seeded From UniProt

complete

protected

part_of

GO:0005776

autophagosome

PMID:24453320

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:1902513

regulation of organelle transport along microtubule

PMID:24453320

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0017157

regulation of exocytosis

PMID:24366265

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050769

positive regulation of neurogenesis

PMID:24355921

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048011

neurotrophin TRK receptor signaling pathway

PMID:24355921

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008089

anterograde axonal transport

PMID:24355921

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0021979

hypothalamus cell differentiation

PMID:24355921

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1902857

positive regulation of non-motile cilium assembly

PMID:21985783

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0021549

cerebellum development

PMID:18636121

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0031587

positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

PMID:15379999

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0098957

anterograde axonal transport of mitochondrion

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1914345
PANTHER:PTN001813314

P

Seeded From UniProt

complete

protected

involved_in

GO:0048311

mitochondrion distribution

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0262872
PANTHER:PTN001039683

P

Seeded From UniProt

complete

protected

involved_in

GO:0048011

neurotrophin TRK receptor signaling pathway

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1261831
PANTHER:PTN000405662

P

Seeded From UniProt

complete

protected

involved_in

GO:0047496

vesicle transport along microtubule

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1261831
PANTHER:PTN001039683

P

Seeded From UniProt

complete

protected

part_of

GO:0032839

dendrite cytoplasm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1918077
PANTHER:PTN001813314

C

Seeded From UniProt

complete

protected

part_of

GO:0031410

cytoplasmic vesicle

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1261831
PANTHER:PTN001039683

C

Seeded From UniProt

complete

protected

part_of

GO:0030425

dendrite

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1918077
PANTHER:PTN001813314
RGD:1307844
RGD:620915
RGD:68327

C

Seeded From UniProt

complete

protected

involved_in

GO:0022008

neurogenesis

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1261831
PANTHER:PTN001813314

P

Seeded From UniProt

complete

protected

enables

GO:0017022

myosin binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0262872
PANTHER:PTN001039683

F

Seeded From UniProt

complete

protected

involved_in

GO:0008104

protein localization

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001039683
UniProtKB:P54257

P

Seeded From UniProt

complete

protected

involved_in

GO:0008089

anterograde axonal transport

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1261831
PANTHER:PTN001813314
RGD:68327

P

Seeded From UniProt

complete

protected

involved_in

GO:0006605

protein targeting

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001039683
RGD:620915

P

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0262872
PANTHER:PTN001039683
RGD:620915
UniProtKB:Q9UPV9

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001039683
RGD:620915
RGD:68327
UniProtKB:Q9UPV9

C

Seeded From UniProt

complete

protected

enables

GO:0005102

signaling receptor binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001813314
RGD:620915
RGD:68327

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1902857

positive regulation of non-motile cilium assembly

PMID:21985783

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000540)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1902430

negative regulation of amyloid-beta formation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

P

Seeded From UniProt

complete

protected

part_of

GO:0099524

postsynaptic cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

C

Seeded From UniProt

complete

protected

part_of

GO:0099523

presynaptic cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0099149

regulation of postsynaptic neurotransmitter receptor internalization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

P

Seeded From UniProt

complete

protected

part_of

GO:0098982

GABA-ergic synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0090261

positive regulation of inclusion body assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

P

Seeded From UniProt

complete

protected

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

C

Seeded From UniProt

complete

protected

enables

GO:0048403

brain-derived neurotrophic factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0047496

vesicle transport along microtubule

PMID:15242649

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045742

positive regulation of epidermal growth factor receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

P

Seeded From UniProt

complete

protected

enables

GO:0044325

ion channel binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

F

Seeded From UniProt

complete

protected

part_of

GO:0043679

axon terminus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

C

Seeded From UniProt

complete

protected

part_of

GO:0043005

neuron projection

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

C

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032901

positive regulation of neurotrophin production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032230

positive regulation of synaptic transmission, GABAergic

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0031587

positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

P

Seeded From UniProt

complete

protected

part_of

GO:0031410

cytoplasmic vesicle

PMID:15242649

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0031175

neuron projection development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

P

Seeded From UniProt

complete

protected

part_of

GO:0030426

growth cone

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

C

Seeded From UniProt

complete

protected

part_of

GO:0030425

dendrite

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

C

Seeded From UniProt

complete

protected

enables

GO:0019904

protein domain specific binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

F

Seeded From UniProt

complete

protected

part_of

GO:0016234

inclusion body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P54257

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0010976

positive regulation of neuron projection development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0008104

protein localization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P54257

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0008090

retrograde axonal transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0008089

anterograde axonal transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

P

Seeded From UniProt

complete

protected

part_of

GO:0005814

centriole

PMID:21985783

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000540)

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

C

Seeded From UniProt

complete

protected

enables

GO:0005102

signaling receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:68327

F

Seeded From UniProt

complete

protected

part_of

GO:1904115

axon cytoplasm

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008089

C

Seeded From UniProt

complete

protected

part_of

GO:1904115

axon cytoplasm

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008089

C

Seeded From UniProt

complete

protected

part_of

GO:1904115

axon cytoplasm

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008089

C

Seeded From UniProt

complete

protected

part_of

GO:1904115

axon cytoplasm

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008089

C

Seeded From UniProt

complete

protected

part_of

GO:1904115

axon cytoplasm

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0098957

C

Seeded From UniProt

complete

protected

part_of

GO:0016234

inclusion body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54257
ensembl:ENSP00000334002

C

Seeded From UniProt

complete

protected

involved_in

GO:0008104

protein localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54257
ensembl:ENSP00000334002

P

Seeded From UniProt

complete

protected

involved_in

GO:0006914

autophagy

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0072

P

Seeded From UniProt

complete

protected

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

complete

protected

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

protected

involved_in

GO:0006887

exocytosis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0268

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

protected

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

protected

involved_in

GO:0030030

cell projection organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0970

P

Seeded From UniProt

complete

protected

part_of

GO:0045202

synapse

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0770

C

Seeded From UniProt

complete

protected

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

protected

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

protected

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

protected

part_of

GO:0005764

lysosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0458
UniProtKB-SubCell:SL-0158

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

part_of

GO:0030424

axon

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0279

C

Seeded From UniProt

complete

protected

part_of

GO:0005776

autophagosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0023

C

Seeded From UniProt

complete

protected

part_of

GO:0008021

synaptic vesicle

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0259

C

Seeded From UniProt

complete




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