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MOUSE:SIRT1

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0045768

positive regulation of anti-apoptosis

PMID:20923823

ECO:0000314

P

Figure 3

complete
CACAO 2323

protected

involved_in

GO:1900113

negative regulation of histone H3-K9 trimethylation

PMID:25526086

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(ENSEMBL:ENSMUSG00000035783)|has_direct_input:(ENSEMBL:ENSMUSG00000032085)

Seeded From UniProt

complete

protected

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:25526086

ECO:0000314

direct assay evidence used in manual assertion

F

  • has_direct_input:(ENSEMBL:ENSMUSG00000035783)
  • occurs_at:(SO:0001952)|has_direct_input(ENSEMBL:ENSMUSG00000032085)
  • occurs_at:(SO:0001952)|has_direct_input(ENSEMBL:ENSMUSG00000015605)
  • occurs_at:(SO:0001952)|has_direct_input(ENSEMBL:ENSMUSG00000005583)
  • occurs_at:(SO:0001952)|has_direct_input(ENSEMBL:ENSMUSG00000020542)
  • occurs_at:(SO:0001952)

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:25526086

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_transcription_of:(ENSEMBL:ENSMUSG00000035783)|regulates_transcription_of:(ENSEMBL:ENSMUSG00000032085)|regulates_transcription_of:(ENSEMBL:ENSMUSG00000015605)|regulates_transcription_of:(ENSEMBL:ENSMUSG00000005583)|regulates_transcription_of:(ENSEMBL:ENSMUSG00000020542)

Seeded From UniProt

complete

protected

involved_in

GO:0051152

positive regulation of smooth muscle cell differentiation

PMID:25526086

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010883

regulation of lipid storage

PMID:22315447

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1904179

positive regulation of adipose tissue development

PMID:22315447

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0001525

angiogenesis

PMID:22315447

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010934

macrophage cytokine production

PMID:22315447

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030225

macrophage differentiation

PMID:22315447

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

PMID:20620997

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:20167603

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0033558

protein deacetylase activity

PMID:20167603

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0090335

regulation of brown fat cell differentiation

PMID:20620997

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0033210

leptin-mediated signaling pathway

PMID:20620997

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0044321

response to leptin

PMID:20620997

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043433

negative regulation of DNA-binding transcription factor activity

PMID:20955178

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:O35426)

Seeded From UniProt

complete

protected

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:20955178

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1902237

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

PMID:20955178

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006476

protein deacetylation

PMID:18662546

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032922

circadian regulation of gene expression

PMID:18662546

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:18662546

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0007623

circadian rhythm

PMID:18662546

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

PMID:19299583

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0032922

circadian regulation of gene expression

PMID:19299583

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0033558

protein deacetylase activity

PMID:24089055

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:1902166

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:11672522

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050872

white fat cell differentiation

PMID:15175761

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045599

negative regulation of fat cell differentiation

PMID:15175761

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035358

regulation of peroxisome proliferator activated receptor signaling pathway

PMID:15175761

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0034979

NAD-dependent protein deacetylase activity

PMID:11672523

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0019904

protein domain specific binding

PMID:15175761

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q60974

F

Seeded From UniProt

complete

protected

involved_in

GO:0009267

cellular response to starvation

PMID:15175761

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006642

triglyceride mobilization

PMID:15175761

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006476

protein deacetylation

PMID:19470756

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0000948)|has_direct_input(UniProtKB:P11103)

Seeded From UniProt

complete

protected

involved_in

GO:0006476

protein deacetylation

PMID:11672523

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:19470756

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:19470756

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0003714

transcription corepressor activity

PMID:15175761

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0002039

p53 binding

PMID:11672522

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P02340

F

Seeded From UniProt

complete

protected

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:19470756

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:2000774

positive regulation of cellular senescence

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:2000773

negative regulation of cellular senescence

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:2000757

negative regulation of peptidyl-lysine acetylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:2000481

positive regulation of cAMP-dependent protein kinase activity

PMID:18687677

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:2000111

positive regulation of macrophage apoptotic process

PMID:20042607

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0071479

cellular response to ionizing radiation

PMID:17612497

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0071456

cellular response to hypoxia

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0071356

cellular response to tumor necrosis factor

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0070857

regulation of bile acid biosynthetic process

PMID:20375098

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0055089

fatty acid homeostasis

PMID:17347648

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051898

negative regulation of protein kinase B signaling

PMID:21149730

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0046969

NAD-dependent histone deacetylase activity (H3-K9 specific)

PMID:20972425

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0046628

positive regulation of insulin receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15220471

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0045739

positive regulation of DNA repair

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

enables

GO:0043425

bHLH transcription factor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0042632

cholesterol homeostasis

PMID:17936707

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042542

response to hydrogen peroxide

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0042326

negative regulation of phosphorylation

PMID:17612497

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0035356

cellular triglyceride homeostasis

PMID:17936707

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

colocalizes_with

GO:0035098

ESC/E(Z) complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

enables

GO:0034979

NAD-dependent protein deacetylase activity

PMID:15220471

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0034391

regulation of smooth muscle cell apoptotic process

PMID:17098745

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0033558

protein deacetylase activity

PMID:17521387

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0033558

protein deacetylase activity

PMID:19578370

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0032868

response to insulin

PMID:17901049

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0032071

regulation of endodeoxyribonuclease activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0032007

negative regulation of TOR signaling

PMID:20169165

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0031648

protein destabilization

PMID:17936707

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0031393

negative regulation of prostaglandin biosynthetic process

PMID:20042607

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

PMID:17098745

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0019899

enzyme binding

PMID:20972425

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P04797

F

Seeded From UniProt

complete

protected

enables

GO:0019899

enzyme binding

PMID:19578370

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q91YE5

F

Seeded From UniProt

complete

protected

enables

GO:0019213

deacetylase activity

PMID:18004385

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0016575

histone deacetylation

PMID:20972425

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0016575

histone deacetylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0016239

positive regulation of macroautophagy

PMID:18296641

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0016239

positive regulation of macroautophagy

PMID:21189328

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010906

regulation of glucose metabolic process

PMID:17347648

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010875

positive regulation of cholesterol efflux

PMID:17936707

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:16269335

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0007346

regulation of mitotic cell cycle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0006476

protein deacetylation

PMID:17521387

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:17521387

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:17197703

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005720

nuclear heterochromatin

PMID:18004385

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005719

nuclear euchromatin

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

part_of

GO:0005637

nuclear inner membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:18004385

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0002821

positive regulation of adaptive immune response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0001934

positive regulation of protein phosphorylation

PMID:17901049

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0001678

cellular glucose homeostasis

PMID:15744310

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0001525

angiogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

part_of

GO:0000785

chromatin

PMID:16269335

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0000731

DNA synthesis involved in DNA repair

PMID:17612497

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000720

pyrimidine dimer repair by nucleotide-excision repair

PMID:21149730

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0000012

single strand break repair

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0070932

histone H3 deacetylation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2135607
PANTHER:PTN000872223
RGD:1308542
UniProtKB:Q96EB6
WB:WBGene00004800

P

Seeded From UniProt

complete

protected

enables

GO:0070403

NAD+ binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000119154
PomBase:SPBC16D10.07c
UniProtKB:Q8IXJ6

F

Seeded From UniProt

complete

protected

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0024291
MGI:MGI:2135607
PANTHER:PTN000872223
UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

part_of

GO:0033553

rDNA heterochromatin

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000872223
UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

enables

GO:0017136

NAD-dependent histone deacetylase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0024291
FB:FBgn0038788
MGI:MGI:2135607
PANTHER:PTN000119154
SGD:S000002200
SGD:S000005429
SGD:S000005551
SGD:S000005936
UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

enables

GO:0017136

NAD-dependent histone deacetylase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0024291
FB:FBgn0038788
MGI:MGI:2135607
PANTHER:PTN000119154
SGD:S000002200
SGD:S000005429
SGD:S000005551
SGD:S000005936
UniProtKB:Q8IXJ6
UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

part_of

GO:0005720

nuclear heterochromatin

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2135607
PANTHER:PTN000872223
UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

part_of

GO:0005719

nuclear euchromatin

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000872223
UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0024291
PANTHER:PTN000872223
UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

part_of

GO:0005637

nuclear inner membrane

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000872223
UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

enables

GO:0003714

transcription corepressor activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2135607
PANTHER:PTN000872223
UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

enables

GO:0002039

p53 binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2135607
PANTHER:PTN000872223
UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

enables

GO:0034979

NAD-dependent protein deacetylase activity

PMID:11250901

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:2000774

positive regulation of cellular senescence

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:2000773

negative regulation of cellular senescence

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:2000757

negative regulation of peptidyl-lysine acetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:2000655

negative regulation of cellular response to testosterone stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:2000619

negative regulation of histone H4-K16 acetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:2000614

positive regulation of thyroid-stimulating hormone secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:2000481

positive regulation of cAMP-dependent protein kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:2000270

negative regulation of fibroblast apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1990830

cellular response to leukemia inhibitory factor

PMID:20439489

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:1990254

keratin filament binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1904646

cellular response to amyloid-beta

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903427

negative regulation of reactive oxygen species biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1902176

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1901984

negative regulation of protein acetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1901984

negative regulation of protein acetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1901215

negative regulation of neuron death

PMID:22956852

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88276

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1900181

negative regulation of protein localization to nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0097755

positive regulation of blood vessel diameter

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0097009

energy homeostasis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0090400

stress-induced premature senescence

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0090312

positive regulation of protein deacetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0071900

regulation of protein serine/threonine kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0071456

cellular response to hypoxia

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0071441

negative regulation of histone H3-K14 acetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0071356

cellular response to tumor necrosis factor

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0070932

histone H3 deacetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0070932

histone H3 deacetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0070914

UV-damage excision repair

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0070301

cellular response to hydrogen peroxide

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0061051

positive regulation of cell growth involved in cardiac muscle cell development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060766

negative regulation of androgen receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060548

negative regulation of cell death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060125

negative regulation of growth hormone secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051898

negative regulation of protein kinase B signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051574

positive regulation of histone H3-K9 methylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051097

negative regulation of helicase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

enables

GO:0051019

mitogen-activated protein kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0046628

positive regulation of insulin receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045892

negative regulation of transcription, DNA-templated

PMID:15381699

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045766

positive regulation of angiogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045739

positive regulation of DNA repair

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045722

positive regulation of gluconeogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045722

positive regulation of gluconeogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045471

response to ethanol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045348

positive regulation of MHC class II biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043536

positive regulation of blood vessel endothelial cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043433

negative regulation of DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

enables

GO:0043425

bHLH transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

enables

GO:0043422

protein kinase B binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

F

Seeded From UniProt

complete

protected

enables

GO:0043398

HLH domain binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043392

negative regulation of DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0042981

regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0042595

behavioral response to starvation

PMID:20668205

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2677369

P

has_participant:(EMAPA:35417)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0042542

response to hydrogen peroxide

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

enables

GO:0042393

histone binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0042326

negative regulation of phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0042127

regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0035774

positive regulation of insulin secretion involved in cellular response to glucose stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

enables

GO:0035257

nuclear hormone receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

colocalizes_with

GO:0035098

ESC/E(Z) complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0034983

peptidyl-lysine deacetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

enables

GO:0034979

NAD-dependent protein deacetylase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

enables

GO:0033558

protein deacetylase activity

PMID:23056314

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

enables

GO:0033558

protein deacetylase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

part_of

GO:0033553

rDNA heterochromatin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032922

circadian regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032720

negative regulation of tumor necrosis factor production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032071

regulation of endodeoxyribonuclease activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032007

negative regulation of TOR signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0031937

positive regulation of chromatin silencing

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0031648

protein destabilization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

part_of

GO:0030426

growth cone

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

C

Seeded From UniProt

complete

protected

part_of

GO:0030424

axon

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0030308

negative regulation of cell growth

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

enables

GO:0019899

enzyme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

enables

GO:0019899

enzyme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

F

Seeded From UniProt

complete

protected

enables

GO:0019213

deacetylase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0018394

peptidyl-lysine acetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

enables

GO:0017136

NAD-dependent histone deacetylase activity

PMID:10693811

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0017136

NAD-dependent histone deacetylase activity

PMID:16959573

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

enables

GO:0017136

NAD-dependent histone deacetylase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

enables

GO:0017136

NAD-dependent histone deacetylase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

F

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0016575

histone deacetylation

PMID:23160044

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:107187

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0016575

histone deacetylation

PMID:10693811

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0016575

histone deacetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0016567

protein ubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0016239

positive regulation of macroautophagy

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0014858

positive regulation of skeletal muscle cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0010976

positive regulation of neuron projection development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0010667

negative regulation of cardiac muscle cell apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0010629

negative regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0010460

positive regulation of heart rate

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

enables

GO:0008134

transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

enables

GO:0008022

protein C-terminus binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0007346

regulation of mitotic cell cycle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0007283

spermatogenesis

PMID:12482959

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2448246

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006476

protein deacetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006476

protein deacetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006344

maintenance of chromatin silencing

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006343

establishment of chromatin silencing

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006325

chromatin organization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

C

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

PMID:26767982

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

part_of

GO:0005720

nuclear heterochromatin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

part_of

GO:0005719

nuclear euchromatin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

part_of

GO:0005677

chromatin silencing complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

part_of

GO:0005637

nuclear inner membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

part_of

GO:0005635

nuclear envelope

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:15381699

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:12482959

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000349)

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308542

C

Seeded From UniProt

complete

protected

enables

GO:0004407

histone deacetylase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

enables

GO:0003714

transcription corepressor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0002821

positive regulation of adaptive immune response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

enables

GO:0002039

p53 binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0001542

ovulation from ovarian follicle

PMID:12482959

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2448246

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0001525

angiogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

part_of

GO:0000790

nuclear chromatin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0000720

pyrimidine dimer repair by nucleotide-excision repair

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0000183

chromatin silencing at rDNA

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0000012

single strand break repair

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96EB6

P

Seeded From UniProt

complete

protected

involved_in

GO:0061647

histone H3-K9 modification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046969

P

Seeded From UniProt

complete

protected

involved_in

GO:1990619

histone H3-K9 deacetylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046969

P

Seeded From UniProt

complete

protected

involved_in

GO:2000774

positive regulation of cellular senescence

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:2000773

negative regulation of cellular senescence

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:2000757

negative regulation of peptidyl-lysine acetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:2000655

negative regulation of cellular response to testosterone stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:2000619

negative regulation of histone H4-K16 acetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:2000481

positive regulation of cAMP-dependent protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

enables

GO:1990254

keratin filament binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

involved_in

GO:1902176

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:1901984

negative regulation of protein acetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0090400

stress-induced premature senescence

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0071900

regulation of protein serine/threonine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0071456

cellular response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0071441

negative regulation of histone H3-K14 acetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0071356

cellular response to tumor necrosis factor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0070932

histone H3 deacetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0070914

UV-damage excision repair

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0070301

cellular response to hydrogen peroxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0060766

negative regulation of androgen receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0051898

negative regulation of protein kinase B signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0051574

positive regulation of histone H3-K9 methylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0051097

negative regulation of helicase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

enables

GO:0051019

mitogen-activated protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

involved_in

GO:0046628

positive regulation of insulin receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0045766

positive regulation of angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0045739

positive regulation of DNA repair

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0045722

positive regulation of gluconeogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0045348

positive regulation of MHC class II biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0043536

positive regulation of blood vessel endothelial cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0043433

negative regulation of DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

enables

GO:0043425

bHLH transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

enables

GO:0043398

HLH domain binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

involved_in

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

involved_in

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0042542

response to hydrogen peroxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

enables

GO:0042393

histone binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

involved_in

GO:0042326

negative regulation of phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0042127

regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

enables

GO:0035257

nuclear hormone receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

part_of

GO:0035098

ESC/E(Z) complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

involved_in

GO:0034983

peptidyl-lysine deacetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

enables

GO:0034979

NAD-dependent protein deacetylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

enables

GO:0033558

protein deacetylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

part_of

GO:0033553

rDNA heterochromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

involved_in

GO:0032922

circadian regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0032071

regulation of endodeoxyribonuclease activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0032007

negative regulation of TOR signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0031937

positive regulation of chromatin silencing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0031648

protein destabilization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0030308

negative regulation of cell growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

enables

GO:0019899

enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

enables

GO:0019213

deacetylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

involved_in

GO:0018394

peptidyl-lysine acetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

enables

GO:0017136

NAD-dependent histone deacetylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

involved_in

GO:0016575

histone deacetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0016239

positive regulation of macroautophagy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0010629

negative regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

enables

GO:0008022

protein C-terminus binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

involved_in

GO:0007346

regulation of mitotic cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0006979

response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0006476

protein deacetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0006344

maintenance of chromatin silencing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0006343

establishment of chromatin silencing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0006325

chromatin organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

part_of

GO:0005730

nucleolus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

part_of

GO:0005720

nuclear heterochromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

part_of

GO:0005719

nuclear euchromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

part_of

GO:0005677

chromatin silencing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

part_of

GO:0005637

nuclear inner membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

part_of

GO:0005635

nuclear envelope

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

enables

GO:0004407

histone deacetylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

enables

GO:0003714

transcription corepressor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

involved_in

GO:0002821

positive regulation of adaptive immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

enables

GO:0002039

p53 binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

F

Seeded From UniProt

complete

protected

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0001525

angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

part_of

GO:0000790

nuclear chromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

involved_in

GO:0000720

pyrimidine dimer repair by nucleotide-excision repair

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0000183

chromatin silencing at rDNA

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

involved_in

GO:0000012

single strand break repair

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q96EB6
ensembl:ENSP00000212015

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A024QZQ1
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A024QZQ1
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A024QZQ1
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A024QZQ1
ensembl:ENSP00000212015

C

Seeded From UniProt

complete

protected

enables

GO:0070403

NAD+ binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003000

F

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

Reactome:R-MMU-9626966
Reactome:R-MMU-5211233

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

protected

involved_in

GO:0007517

muscle organ development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0517

P

Seeded From UniProt

complete

protected

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

involved_in

GO:0006364

rRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0698

P

Seeded From UniProt

complete

protected

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

protected

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

protected

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

protected

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0465

C

Seeded From UniProt

complete




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