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MOUSE:GDF8

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0048632

negative regulation of skeletal muscle tissue growth

PMID:9139826

ECO:0000315

P

Fig 4a-d; disruption of GDF-8's normal functioning

complete
CACAO 2282

public

GO:0048632

negative regulation of skeletal muscle tissue growth

PMID:21390326

ECO:0000315

P

Table 1 and Figure 2 show the Gastrocnemius, Quadriceps, and Triceps muscles all were significantly larger in weight(g) in myostatin deficient mice compared to normal myostatin mice.

complete
CACAO 3684

public

GO:0019222

regulation of metabolic process

PMID:11877467

ECO:0000315

P

Table 2 shows Mstn–/– mice had higher rates of total and resting O2 consumption compared with Mstn+/+ mice, which is expected given the higher body weights of Mstn–/– mice. If the data are expressed as a function of body weight, however, Mstn–/– mice actually had lower rates of total and resting O2 consumption compared with Mstn+/+ mice.

complete
CACAO 3737

public

GO:0019217

regulation of fatty acid metabolic process

PMID:21390326

ECO:0000315

P

Figure 4 shows mg fatty acids per g of muscle tissue is significantly less in myostatin depleted mice fed a high-fat diet.

complete
CACAO 3741

public

GO:0043610

regulation of carbohydrate utilization

PMID:21390326

ECO:0000315

P

Figure 3 shows blood glucose concentration is significantly lower in myostatin depleted mice fed a high-fat diet for 5 months, 90 min after ip glucose injection.

complete
CACAO 3743

public

GO:0019216

PMID:21390326

ECO:0000315

Figure 5 shows that myostatin depleted mice have a significantly lower incidence and severity of hepatic statosis when fed a high-fat diet for 5 months.

complete
CACAO 3746

public

GO:0048632

negative regulation of skeletal muscle tissue growth

PMID:11877467

ECO:0000315

P

Figure 1a shows the increased mass of triceps muscle in Mstn -/- mice at different ages as well as an apparent dose-dependency on muscle mass.

complete
CACAO 3750

public

GO:0019216

regulation of lipid metabolic process

PMID:11877467

ECO:0000315

P

Figure 1b-g shows the significant differences in fat pad mass between Mstn -/- and Mstn +/+ mice after 2 months of age.

complete
CACAO 3753

public

GO:0033673

negative regulation of kinase activity

PMID:19357233

ECO:0000315

P

Results section/ Increased muscle weight and CK activity... Section; Fig. 7 B; Show Creatine Kinase activity increased by myostatin expression inhitbion in vivo [mice], activity bio marker used. Mice had Severe Combined Immunodeficiency and no MSTN mutations

complete
CACAO 6339

public

GO:0046627

negative regulation of insulin receptor signaling pathway

PMID:16182246

ECO:0000315

P

Responses of insulin action.. Section; Fig 3; muscle protein kinase Akt intermediate phosphorylation was measured due to is role in the insulin signaling pathway, transgenic mice showed greater levels [inhibition of myostatin] of phosphorylation

complete
CACAO 6340

protected

involved_in

GO:0014839

myoblast migration involved in skeletal muscle regeneration

PMID:19406121

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010759

positive regulation of macrophage chemotaxis

PMID:19406121

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010592

positive regulation of lamellipodium assembly

PMID:19406121

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0008201

heparin binding

PMID:28257634

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:28257634

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0008201

heparin binding

PMID:19644449

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0042803

protein homodimerization activity

PMID:19644449

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0048632

negative regulation of skeletal muscle tissue growth

PMID:24076600

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0046627

negative regulation of insulin receptor signaling pathway

PMID:16182246

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0033673

negative regulation of kinase activity

PMID:19357233

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:2000818

negative regulation of myoblast proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O42221

P

Seeded From UniProt

complete

protected

involved_in

GO:1902725

negative regulation of satellite cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O42221

P

Seeded From UniProt

complete

protected

involved_in

GO:1902723

negative regulation of skeletal muscle satellite cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O42221

P

Seeded From UniProt

complete

protected

involved_in

GO:0048632

negative regulation of skeletal muscle tissue growth

PMID:11877467

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048632

negative regulation of skeletal muscle tissue growth

PMID:21390326

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048632

negative regulation of skeletal muscle tissue growth

PMID:9139826

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:12595574

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0060395

SMAD protein signal transduction

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1338027
MGI:MGI:88180
MGI:MGI:88182
MGI:MGI:95689
MGI:MGI:97359
PANTHER:PTN000218063
UniProtKB:O95390
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:P18075
UniProtKB:P22004
UniProtKB:P43026
UniProtKB:P61812
UniProtKB:Q6KF10
UniProtKB:Q99988

P

Seeded From UniProt

complete

protected

involved_in

GO:0048468

cell development

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103302
PANTHER:PTN000218063

P

Seeded From UniProt

complete

protected

involved_in

GO:0043408

regulation of MAPK cascade

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107335
PANTHER:PTN000218063

P

Seeded From UniProt

complete

protected

involved_in

GO:0042981

regulation of apoptotic process

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98726
PANTHER:PTN000218063

P

Seeded From UniProt

complete

protected

involved_in

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107335
MGI:MGI:1338820
MGI:MGI:88182
MGI:MGI:95684
MGI:MGI:98727
PANTHER:PTN000218063
UniProtKB:O95393
UniProtKB:P01137
UniProtKB:P08476
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:P18075
UniProtKB:P22003
UniProtKB:P22004
UniProtKB:Q6KF10
UniProtKB:Q7Z4P5
UniProtKB:Q96S42
UniProtKB:Q9UK05

P

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000490
MGI:MGI:103302
MGI:MGI:1338027
MGI:MGI:88177
MGI:MGI:88180
MGI:MGI:95691
MGI:MGI:98725
MGI:MGI:98726
PANTHER:PTN000218063
RGD:1305979
RGD:2211
RGD:2212
RGD:2213
RGD:2214
RGD:2912
RGD:2913
RGD:3115
RGD:3851
RGD:62074
RGD:620743
RGD:621512
RGD:69051
RGD:70491
UniProtKB:O14793
UniProtKB:O42220
UniProtKB:O95393
UniProtKB:P01137
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:P18075
UniProtKB:P30371
UniProtKB:P61812
UniProtKB:Q96S42
UniProtKB:Q99988
WB:WBGene00000903

C

Seeded From UniProt

complete

protected

enables

GO:0005160

transforming growth factor beta receptor binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98725
PANTHER:PTN000218063
UniProtKB:P61812

F

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000218063
UniProtKB:P08476
UniProtKB:P12644

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0071549

cellular response to dexamethasone stimulus

PMID:23752591

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051898

negative regulation of protein kinase B signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14793

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0048632

negative regulation of skeletal muscle tissue growth

PMID:18286185

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3778375

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0048632

negative regulation of skeletal muscle tissue growth

PMID:18286185

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2148177

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0048632

negative regulation of skeletal muscle tissue growth

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14793

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0048632

negative regulation of skeletal muscle tissue growth

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3115

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0046716

muscle cell cellular homeostasis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14793

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14793

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045662

negative regulation of myoblast differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14793

P

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14793

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0014741

negative regulation of muscle hypertrophy

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3115

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:12595574

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3115

C

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14793

C

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3115

C

Seeded From UniProt

complete

protected

enables

GO:0005102

signaling receptor binding

PMID:11459935

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P27038
UniProtKB:P27040

F

Seeded From UniProt

complete

protected

enables

GO:0005102

signaling receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O14793

F

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

protected

involved_in

GO:0051898

negative regulation of protein kinase B signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14793
ensembl:ENSP00000260950

P

Seeded From UniProt

complete

protected

involved_in

GO:0048632

negative regulation of skeletal muscle tissue growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14793
ensembl:ENSP00000260950

P

Seeded From UniProt

complete

protected

involved_in

GO:0046716

muscle cell cellular homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14793
ensembl:ENSP00000260950

P

Seeded From UniProt

complete

protected

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14793
ensembl:ENSP00000260950

P

Seeded From UniProt

complete

protected

involved_in

GO:0045662

negative regulation of myoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14793
ensembl:ENSP00000260950

P

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14793
ensembl:ENSP00000260950

F

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14793
ensembl:ENSP00000260950

C

Seeded From UniProt

complete

protected

enables

GO:0005102

signaling receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O14793
ensembl:ENSP00000260950

F

Seeded From UniProt

complete

protected

involved_in

GO:0051602

response to electrical stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35312
ensembl:ENSRNOP00000038159

P

Seeded From UniProt

complete

protected

involved_in

GO:0051384

response to glucocorticoid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35312
ensembl:ENSRNOP00000038159

P

Seeded From UniProt

complete

protected

involved_in

GO:0048632

negative regulation of skeletal muscle tissue growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35312
ensembl:ENSRNOP00000038159

P

Seeded From UniProt

complete

protected

involved_in

GO:0045471

response to ethanol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35312
ensembl:ENSRNOP00000038159

P

Seeded From UniProt

complete

protected

involved_in

GO:0043627

response to estrogen

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35312
ensembl:ENSRNOP00000038159

P

Seeded From UniProt

complete

protected

involved_in

GO:0043403

skeletal muscle tissue regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35312
ensembl:ENSRNOP00000038159

P

Seeded From UniProt

complete

protected

involved_in

GO:0033574

response to testosterone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35312
ensembl:ENSRNOP00000038159

P

Seeded From UniProt

complete

protected

involved_in

GO:0022602

ovulation cycle process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35312
ensembl:ENSRNOP00000038159

P

Seeded From UniProt

complete

protected

involved_in

GO:0014850

response to muscle activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35312
ensembl:ENSRNOP00000038159

P

Seeded From UniProt

complete

protected

involved_in

GO:0014741

negative regulation of muscle hypertrophy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35312
ensembl:ENSRNOP00000038159

P

Seeded From UniProt

complete

protected

involved_in

GO:0014732

skeletal muscle atrophy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35312
ensembl:ENSRNOP00000038159

P

Seeded From UniProt

complete

protected

involved_in

GO:0009629

response to gravity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35312
ensembl:ENSRNOP00000038159

P

Seeded From UniProt

complete

protected

involved_in

GO:0009408

response to heat

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35312
ensembl:ENSRNOP00000038159

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35312
ensembl:ENSRNOP00000038159

C

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35312
ensembl:ENSRNOP00000038159

C

Seeded From UniProt

complete

protected

enables

GO:0005102

signaling receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015616

F

Seeded From UniProt

complete

protected

enables

GO:0008083

growth factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001839
InterPro:IPR015616
InterPro:IPR017948

F

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

Reactome:R-NUL-9625523

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

protected

enables

GO:0008201

heparin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0358

F

Seeded From UniProt

complete

protected

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete




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