GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
Holtz, ML and Misra, RP (2011) Serum response factor is required for cell contact maintenance but dispensable for proliferation in visceral yolk sac endothelium. BMC Dev. Biol. 11:18
Endothelial-specific knockout of the transcription factor serum response factor (SRF) results in embryonic lethality by mid-gestation. The associated phenotype exhibits vascular failure in embryos as well as visceral yolk sac (VYS) tissues. Previous data suggest that this vascular failure is caused by alterations in cell-cell and cell-matrix contacts. In the current study, we sought to more carefully address the role of SRF in endothelial function and cell contact interactions in VYS tissues.
Actins/genetics; Actins/metabolism; Animals; Antigens, CD/genetics; Antigens, CD29/genetics; Blood Vessels/embryology; Blood Vessels/metabolism; Cadherins/genetics; Cell Adhesion; Cell Proliferation; Cell-Matrix Junctions/physiology; Embryo, Mammalian/metabolism; Endothelial Cells/cytology; Endothelial Cells/metabolism; Endothelium, Vascular/embryology; Endothelium, Vascular/metabolism; Fibronectins/genetics; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Integrin alpha5/genetics; Membrane Proteins/genetics; Mesoderm/cytology; Mesoderm/embryology; Mesoderm/metabolism; Mice; Mice, Transgenic; Polymerase Chain Reaction; Receptor, TIE-2/genetics; Serum Response Factor/genetics; Serum Response Factor/metabolism; Signal Transduction; Yolk Sac/blood supply; Yolk Sac/metabolism