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Holtz, ML and Misra, RP (2011) Serum response factor is required for cell contact maintenance but dispensable for proliferation in visceral yolk sac endothelium. BMC Dev. Biol. 11:18


Endothelial-specific knockout of the transcription factor serum response factor (SRF) results in embryonic lethality by mid-gestation. The associated phenotype exhibits vascular failure in embryos as well as visceral yolk sac (VYS) tissues. Previous data suggest that this vascular failure is caused by alterations in cell-cell and cell-matrix contacts. In the current study, we sought to more carefully address the role of SRF in endothelial function and cell contact interactions in VYS tissues.


PubMed PMC3065428 Online version:10.1186/1471-213X-11-18


Actins/genetics; Actins/metabolism; Animals; Antigens, CD/genetics; Antigens, CD29/genetics; Blood Vessels/embryology; Blood Vessels/metabolism; Cadherins/genetics; Cell Adhesion; Cell Proliferation; Cell-Matrix Junctions/physiology; Embryo, Mammalian/metabolism; Endothelial Cells/cytology; Endothelial Cells/metabolism; Endothelium, Vascular/embryology; Endothelium, Vascular/metabolism; Fibronectins/genetics; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Integrin alpha5/genetics; Membrane Proteins/genetics; Mesoderm/cytology; Mesoderm/embryology; Mesoderm/metabolism; Mice; Mice, Transgenic; Polymerase Chain Reaction; Receptor, TIE-2/genetics; Serum Response Factor/genetics; Serum Response Factor/metabolism; Signal Transduction; Yolk Sac/blood supply; Yolk Sac/metabolism