GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

TableEdit

Jump to: navigation, search

PMID:14517545

You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor

Citation

Bylund, M, Andersson, E, Novitch, BG and Muhr, J (2003) Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat. Neurosci. 6:1162-8

Abstract

The generation of neurons from stem cells involves the activity of proneural basic helix-loop-helix (bHLH) proteins, but the mechanism by which these proteins irreversibly commit stem cells to neuronal differentiation is not known. Here we report that expression of the transcription factors Sox1, Sox2 and Sox3 (Sox1-3) is a critical determinant of neurogenesis. Using chick in ovo electroporation, we found that Sox1-3 transcription factors keep neural cells undifferentiated by counteracting the activity of proneural proteins. Conversely, the capacity of proneural bHLH proteins to direct neuronal differentiation critically depends on their ability to suppress Sox1-3 expression in CNS progenitors. These data suggest that the generation of neurons from stem cells depends on the inhibition of Sox1-3 expression by proneural proteins.

Links

PubMed Online version:10.1038/nn1131

Keywords

Animals; Avian Proteins; Basic Helix-Loop-Helix Transcription Factors; Bromodeoxyuridine/metabolism; Cell Differentiation/physiology; Chick Embryo; DNA-Binding Proteins/metabolism; DNA-Binding Proteins/physiology; Drosophila; Electroporation/methods; Embryonic Induction; Eye Proteins/metabolism; Gene Expression Regulation, Developmental; HMGB Proteins; Helix-Loop-Helix Motifs/physiology; High Mobility Group Proteins/metabolism; High Mobility Group Proteins/physiology; Homeodomain Proteins/metabolism; LIM-Homeodomain Proteins; Membrane Glycoproteins; Mice; Nerve Tissue Proteins/metabolism; Neurofilament Proteins/metabolism; Neurons/metabolism; Neuropeptides/metabolism; Nuclear Proteins/metabolism; Nuclear Proteins/physiology; PAX7 Transcription Factor; Phosphopyruvate Hydratase/metabolism; Proto-Oncogene Proteins c-myc/metabolism; SOXB1 Transcription Factors; Spinal Cord/cytology; Spinal Cord/embryology; Spinal Cord/physiology; Stem Cells; Time Factors; Transcription Factors/metabolism; Tubulin/metabolism; Vertebrates

public



Cancel