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PMID:21093267
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Citation |
Dubruille, R, Orsi, GA, Delabaere, L, Cortier, E, Couble, P, Marais, GA and Loppin, B (2010) Specialization of a Drosophila capping protein essential for the protection of sperm telomeres. Curr. Biol. 20:2090-9 |
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Abstract |
A critical function of telomeres is to prevent fusion of chromosome ends by the DNA repair machinery. In Drosophila somatic cells, assembly of the protecting capping complex at telomeres notably involves the recruitment of HOAP, HP1, and their recently identified partner, HipHop. We previously showed that the hiphop gene was duplicated before the radiation of the melanogaster subgroup of species, giving birth to K81, a unique paternal effect gene specifically expressed in the male germline. |
Links |
PubMed Online version:10.1016/j.cub.2010.11.013 |
Keywords |
Animals; Animals, Genetically Modified; Chromosomal Proteins, Non-Histone/genetics; Chromosomal Proteins, Non-Histone/metabolism; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/genetics; Drosophila melanogaster/metabolism; Epigenesis, Genetic; Female; Male; Multigene Family; Phylogeny; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Spermatozoa/physiology; Telomere/metabolism |
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