GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com


Jump to: navigation, search


You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor


Krizhanovsky, V and Ben-Arie, N (2006) A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors. Mech. Dev. 123:67-75


Cerebellar granule cells, the most abundant neurons in the mammalian brain, arise in the rhombic lip located at the roof of the brain's fourth ventricle. Bordering the rhombic lip is the choroid plexus, a non-neuronal structure, composed of blood vessels enveloped by epithelial cells. Here, we show a striking decrease in neural differentiation of rhombic lip-derived cells, which failed to extend neuritic processes and attenuate Math1 promoter activity, when co-cultured with choroid plexus cells. Moreover, a blocking antibody against BMP7, a morphogenetic protein expressed in the choroid plexus, blocked the inhibitory effect of the choroid plexus, whereas purified BMP7 mimicked this effect, demonstrating causal involvement of BMP. On the other hand, the BMP antagonist NBL1 promoted neurogenesis in rhombic lip cultures from Math1 null mice displaying arrested differentiation. Our data indicate that besides its secretory and barrier functions, the choroid plexus has a novel role in attenuating the differentiation of adjacent neural progenitors.


PubMed Online version:10.1016/j.mod.2005.09.005


Animals; Basic Helix-Loop-Helix Transcription Factors/deficiency; Basic Helix-Loop-Helix Transcription Factors/genetics; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins/metabolism; Cell Differentiation; Cerebellum/cytology; Cerebellum/embryology; Cerebellum/metabolism; Choroid Plexus/embryology; Choroid Plexus/metabolism; Gene Expression Regulation, Developmental; Mice; Mice, Knockout; Models, Neurological; Multipotent Stem Cells/cytology; Multipotent Stem Cells/metabolism; Neurons/cytology; Neurons/metabolism; Proteins/genetics; Proteins/metabolism; Transforming Growth Factor beta/metabolism