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Moore, JT, McKee, DD, Slentz-Kesler, K, Moore, LB, Jones, SA, Horne, EL, Su, JL, Kliewer, SA, Lehmann, JM and Willson, TM (1998) Cloning and characterization of human estrogen receptor beta isoforms. Biochem. Biophys. Res. Commun. 247:75-8
Multiple transcripts which arise from the human estrogen receptor beta (ER beta) gene have been characterized. Three full length isoforms of the hER beta gene, designated hER beta 1-3, were identified in a testis cDNA library. An additional two isoforms, designated hER beta 4 and hER beta 5, were identified by PCR amplification from testis cDNA and from the MDA-MB 435 cell line. hER beta 1 corresponds to the previously described hER beta. All five isoforms diverge at a common position within the predicted helix 10 of the ligand binding domain of hER beta, with nucleotide sequences consistent with differential exon usage. The hER beta isoform mRNAs displayed a differential pattern of expression in human tissues and in tumor cell lines when analyzed by RT-PCR. Further characterization of the three full length isoforms, hER beta 1-3, by in vitro band shift studies indicated that the isoforms were able to form DNA-binding homodimers and heterodimers with each other and with the ER alpha subtype.
Alternative Splicing; Amino Acid Sequence; Base Sequence; Cloning, Molecular; DNA-Binding Proteins/metabolism; Dimerization; Estrogen Receptor beta; Estrogens/genetics; Gene Expression; Humans; Isomerism; Male; Molecular Sequence Data; Organ Specificity/genetics; RNA, Messenger/biosynthesis; Receptors, Estrogen/biosynthesis; Receptors, Estrogen/chemistry; Receptors, Estrogen/genetics; Regulatory Sequences, Nucleic Acid; Testis