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Gouge, CA and Christensen, TW (2010) Drosophila Sld5 is essential for normal cell cycle progression and maintenance of genomic integrity. Biochem. Biophys. Res. Commun. 400:145-50


Essential for the normal functioning of a cell is the maintenance of genomic integrity. Failure in this process is often catastrophic for the organism, leading to cell death or mis-proliferation. Central to genomic integrity is the faithful replication of DNA during S phase. The GINS complex has recently come to light as a critical player in DNA replication through stabilization of MCM2-7 and Cdc45 as a member of the CMG complex which is likely responsible for the processivity of helicase activity during S phase. The GINS complex is made up of 4 members in a 1:1:1:1 ratio: Psf1, Psf2, Psf3, And Sld5. Here we present the first analysis of the function of the Sld5 subunit in a multicellular organism. We show that Drosophila Sld5 interacts with Psf1, Psf2, and Mcm10 and that mutations in Sld5 lead to M and S phase delays with chromosomes exhibiting hallmarks of genomic instability.


PubMed PMC2939264 Online version:10.1016/j.bbrc.2010.08.033


Alleles; Animals; Cell Cycle/genetics; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/cytology; Drosophila melanogaster/genetics; Drosophila melanogaster/physiology; Genomic Instability/genetics; Mitosis; Mutation; Two-Hybrid System Techniques