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Fett, ME, Pilsl, A, Paquet, D, van Bebber, F, Haass, C, Tatzelt, J, Schmid, B and Winklhofer, KF (2010) Parkin is protective against proteotoxic stress in a transgenic zebrafish model. PLoS ONE 5:e11783


Mutations in the gene encoding the E3 ubiquitin ligase parkin (PARK2) are responsible for the majority of autosomal recessive parkinsonism. Similarly to other knockout mouse models of PD-associated genes, parkin knockout mice do not show a substantial neuropathological or behavioral phenotype, while loss of parkin in Drosophila melanogaster leads to a severe phenotype, including reduced lifespan, apoptotic flight muscle degeneration and male sterility. In order to study the function of parkin in more detail and to address possible differences in its role in different species, we chose Danio rerio as a different vertebrate model system.


PubMed PMC2912770 Online version:10.1371/journal.pone.0011783


Animals; Animals, Genetically Modified; Apoptosis/genetics; Apoptosis/physiology; Blotting, Western; Cell Line; Cell Line, Tumor; Dopamine/metabolism; Female; Fluorescent Antibody Technique, Indirect; HeLa Cells; Humans; In Situ Hybridization; Male; Membrane Potential, Mitochondrial/genetics; Membrane Potential, Mitochondrial/physiology; Neurons/metabolism; Polymerase Chain Reaction; Ubiquitin-Protein Ligases/genetics; Ubiquitin-Protein Ligases/metabolism; Zebrafish/genetics; Zebrafish/metabolism