GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

TableEdit

Jump to: navigation, search

PMID:20689587

You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor

Citation

Fett, ME, Pilsl, A, Paquet, D, van Bebber, F, Haass, C, Tatzelt, J, Schmid, B and Winklhofer, KF (2010) Parkin is protective against proteotoxic stress in a transgenic zebrafish model. PLoS ONE 5:e11783

Abstract

Mutations in the gene encoding the E3 ubiquitin ligase parkin (PARK2) are responsible for the majority of autosomal recessive parkinsonism. Similarly to other knockout mouse models of PD-associated genes, parkin knockout mice do not show a substantial neuropathological or behavioral phenotype, while loss of parkin in Drosophila melanogaster leads to a severe phenotype, including reduced lifespan, apoptotic flight muscle degeneration and male sterility. In order to study the function of parkin in more detail and to address possible differences in its role in different species, we chose Danio rerio as a different vertebrate model system.

Links

PubMed PMC2912770 Online version:10.1371/journal.pone.0011783

Keywords

Animals; Animals, Genetically Modified; Apoptosis/genetics; Apoptosis/physiology; Blotting, Western; Cell Line; Cell Line, Tumor; Dopamine/metabolism; Female; Fluorescent Antibody Technique, Indirect; HeLa Cells; Humans; In Situ Hybridization; Male; Membrane Potential, Mitochondrial/genetics; Membrane Potential, Mitochondrial/physiology; Neurons/metabolism; Polymerase Chain Reaction; Ubiquitin-Protein Ligases/genetics; Ubiquitin-Protein Ligases/metabolism; Zebrafish/genetics; Zebrafish/metabolism

public



Cancel