GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
Chen, JG, Willard, FS, Huang, J, Liang, J, Chasse, SA, Jones, AM and Siderovski, DP (2003) A seven-transmembrane RGS protein that modulates plant cell proliferation. Science 301:1728-31
G protein-coupled receptors (GPCRs) at the cell surface activate heterotrimeric G proteins by inducing the G protein alpha (Galpha) subunit to exchange guanosine diphosphate for guanosine triphosphate. Regulators of G protein signaling (RGS) proteins accelerate the deactivation of Galpha subunits to reduce GPCR signaling. Here we identified an RGS protein (AtRGS1) in Arabidopsis that has a predicted structure similar to a GPCR as well as an RGS box with GTPase accelerating activity. Expression of AtRGS1 complemented the pheromone supersensitivity phenotype of a yeast RGS mutant, sst2Delta. Loss of AtRGS1 increased the activity of the Arabidopsis Galpha subunit, resulting in increased cell elongation in hypocotyls in darkness and increased cell production in roots grown in light. These findings suggest that AtRGS1 is a critical modulator of plant cell proliferation.
Alleles; Amino Acid Sequence; Arabidopsis/cytology; Arabidopsis/genetics; Arabidopsis/metabolism; Arabidopsis Proteins/chemistry; Arabidopsis Proteins/genetics; Arabidopsis Proteins/metabolism; Cell Differentiation; Cell Division; Cell Membrane/metabolism; GTP-Binding Protein alpha Subunits; Heterotrimeric GTP-Binding Proteins/metabolism; Meristem/metabolism; Mitosis; Molecular Sequence Data; Mutation; Open Reading Frames; Phenotype; Plant Roots/cytology; Plant Roots/growth & development; Plant Roots/metabolism; Protein Precursors/metabolism; Protein Structure, Tertiary; RGS Proteins/chemistry; RGS Proteins/genetics; RGS Proteins/metabolism; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/metabolism; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/metabolism; Transgenes