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Jayaram, SA, Senti, KA, Tiklová, K, Tsarouhas, V, Hemphälä, J and Samakovlis, C (2008) COPI vesicle transport is a common requirement for tube expansion in Drosophila. PLoS ONE 3:e1964
Tube expansion defects like stenoses and atresias cause devastating human diseases. Luminal expansion during organogenesis begins to be elucidated in several systems but we still lack a mechanistic view of the process in many organs. The Drosophila tracheal respiratory system provides an amenable model to study tube size regulation. In the trachea, COPII anterograde transport of luminal proteins is required for extracellular matrix assembly and the concurrent tube expansion.
Animals; Biological Transport; Coat Protein Complex I/metabolism; Coatomer Protein/metabolism; Drosophila/metabolism; Drosophila Proteins/metabolism; Endoplasmic Reticulum/metabolism; Extracellular Matrix/metabolism; Golgi Apparatus/metabolism; Models, Biological; Mutation; Phenotype; Respiratory System; Trachea/metabolism