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Dean, SO and Spudich, JA (2006) Rho kinase's role in myosin recruitment to the equatorial cortex of mitotic Drosophila S2 cells is for myosin regulatory light chain phosphorylation. PLoS ONE 1:e131


Myosin II recruitment to the equatorial cortex is one of the earliest events in establishment of the cytokinetic contractile ring. In Drosophila S2 cells, we previously showed that myosin II is recruited to the furrow independently of F-actin, and that Rho1 and Rok are essential for this recruitment [1]. Rok phosphorylates several cellular proteins, including the myosin regulatory light chain (RLC).


PubMed PMC1762308 Online version:10.1371/journal.pone.0000131


Animals; Base Sequence; Cell Line; Cytokinesis; Drosophila/cytology; Drosophila/genetics; Drosophila/metabolism; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/metabolism; Mitosis; Myosin Light Chains/genetics; Myosin Light Chains/metabolism; Myosins/genetics; Myosins/metabolism; Phosphorylation; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/metabolism; RNA Interference; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; rho GTP-Binding Proteins/genetics; rho GTP-Binding Proteins/metabolism; rho-Associated Kinases/genetics; rho-Associated Kinases/metabolism