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Frolet, C, Beniazza, M, Roux, L, Gallet, B, Noirclerc-Savoye, M, Vernet, T and Di Guilmi, AM (2010) New adhesin functions of surface-exposed pneumococcal proteins. BMC Microbiol. 10:190


Streptococcus pneumoniae is a widely distributed commensal Gram-positive bacteria of the upper respiratory tract. Pneumococcal colonization can progress to invasive disease, and thus become lethal, reason why antibiotics and vaccines are designed to limit the dramatic effects of the bacteria in such cases. As a consequence, pneumococcus has developed efficient antibiotic resistance, and the use of vaccines covering a limited number of serotypes such as Pneumovax and Prevnar results in the expansion of non-covered serotypes. Pneumococcal surface proteins represent challenging candidates for the development of new therapeutic targets against the bacteria. Despite the number of described virulence factors, we believe that the majority of them remain to be characterized. This is the reason why pneumococcus invasion processes are still largely unknown.


PubMed PMC2911433 Online version:10.1186/1471-2180-10-190


Adhesins, Bacterial/genetics; Adhesins, Bacterial/metabolism; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Humans; Membrane Proteins/genetics; Membrane Proteins/metabolism; Pneumococcal Infections/metabolism; Pneumococcal Infections/microbiology; Protein Binding; Streptococcus pneumoniae/genetics; Streptococcus pneumoniae/metabolism