GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
Schouest, KR, Kurasawa, Y, Furuta, T, Hisamoto, N, Matsumoto, K and Schumacher, JM (2009) The germinal center kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline. PLoS ONE 4:e7450
The germinal center kinases (GCK) constitute a large, highly conserved family of proteins that has been implicated in a wide variety of cellular processes including cell growth and proliferation, polarity, migration, and stress responses. Although diverse, these functions have been attributed to an evolutionarily conserved role for GCKs in the activation of ERK, JNK, and p38 MAP kinase pathways. In addition, multiple GCKs from different species promote apoptotic cell death. In contrast to these paradigms, we found that a C. elegans GCK, GCK-1, functions to inhibit MAP kinase activation and apoptosis in the C. elegans germline. In the absence of GCK-1, a specific MAP kinase isoform is ectopically activated and oocytes undergo abnormal development. Moreover, GCK-1- deficient animals display a significant increase in germ cell death. Our results suggest that individual germinal center kinases act in mechanistically distinct ways and that these functions are likely to depend on organ- and developmental-specific contexts.
Animals; Apoptosis; Caenorhabditis elegans; Caenorhabditis elegans Proteins/metabolism; Cell Proliferation; Cytoplasm/metabolism; Enzyme Activation; Female; Gene Expression Regulation, Enzymologic; Male; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinases/metabolism; Models, Biological; Oocytes/metabolism; Protein Structure, Tertiary; Protein-Serine-Threonine Kinases/metabolism; RNA Interference