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Choy, SW, Wong, YM, Ho, SH and Chow, KL (2007) C. elegans SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory ray development. Biochem. Biophys. Res. Commun. 358:802-7
Mab21 gene family members are required for embryonic development and sensory organ formation in both invertebrates and vertebrates. However, their mechanistic role on differentiation is largely unexplored. We report here the isolation of SIN-3 as a MAB-21 interacting molecule. sin-3 is co-expressed with mab-21 in the ray structural cells and genetically interacts with mab-21 to control sensory organ development. Using pharmacological and RNAi approaches, we demonstrated that histone deacetylase and conserved SIN-3-associated components are required for ray patterning. Conserved physical interactions between these components were also observed, implicating the recruitment of HDAC complex by MAB-21/SIN-3 may occur to determine ray identity in males.
Amino Acid Sequence; Animals; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins/metabolism; Chromatin Assembly and Disassembly; Gene Expression Regulation, Developmental; Genotype; Histone Deacetylases/metabolism; Hydroxamic Acids/metabolism; Male; Models, Genetic; Molecular Sequence Data; Neuropeptides/metabolism; RNA Interference; Sin3 Histone Deacetylase and Corepressor Complex; Transforming Growth Factor beta/metabolism