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Herman, MA, Vassilieva, LL, Horvitz, HR, Shaw, JE and Herman, RK (1995) The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously. Cell 83:101-10
Mutations in the C. elegans gene lin-44 lead to reversals in the polarity of certain asymmetric cell divisions. We have discovered that lin-44 is a member of the Wnt family of genes, which encode secretory glycoproteins implicated in intercellular signaling. Both in situ hybridization experiments using lin-44 transcripts and experiments using reporter constructs designed to mimic patterns of lin-44 expression indicate that lin-44 is expressed in hypodermal cells at the tip of the tail and posterior to the cells with polarities affected by lin-44 mutations. Our mosaic analysis indicates that lin-44 acts cell nonautonomously. We propose that LIN-44 protein is secreted by tail hypodermal cells and affects the polarity of asymmetric cell divisions that occur more anteriorly in the tail.
Amino Acid Sequence; Animals; Base Sequence; Caenorhabditis elegans/cytology; Caenorhabditis elegans/genetics; Caenorhabditis elegans Proteins; Cell Division; Cell Lineage; Cell Polarity/genetics; Chromosomes, Artificial, Yeast; Consensus Sequence; DNA, Complementary/genetics; Disorders of Sex Development; Drosophila Proteins; Drosophila melanogaster/genetics; Gene Expression Regulation; Genes, Reporter; Glycoproteins/chemistry; Glycoproteins/classification; Glycoproteins/genetics; Glycoproteins/physiology; Helminth Proteins/physiology; In Situ Hybridization; Mice; Molecular Sequence Data; Mosaicism; Multigene Family; Phenotype; Proto-Oncogene Proteins/chemistry; Proto-Oncogene Proteins/genetics; Recombinant Fusion Proteins/biosynthesis; Recombinant Fusion Proteins/genetics; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Tail; Wnt1 Protein