GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com


Jump to: navigation, search


You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor


Herman, MA, Vassilieva, LL, Horvitz, HR, Shaw, JE and Herman, RK (1995) The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously. Cell 83:101-10


Mutations in the C. elegans gene lin-44 lead to reversals in the polarity of certain asymmetric cell divisions. We have discovered that lin-44 is a member of the Wnt family of genes, which encode secretory glycoproteins implicated in intercellular signaling. Both in situ hybridization experiments using lin-44 transcripts and experiments using reporter constructs designed to mimic patterns of lin-44 expression indicate that lin-44 is expressed in hypodermal cells at the tip of the tail and posterior to the cells with polarities affected by lin-44 mutations. Our mosaic analysis indicates that lin-44 acts cell nonautonomously. We propose that LIN-44 protein is secreted by tail hypodermal cells and affects the polarity of asymmetric cell divisions that occur more anteriorly in the tail.




Amino Acid Sequence; Animals; Base Sequence; Caenorhabditis elegans/cytology; Caenorhabditis elegans/genetics; Caenorhabditis elegans Proteins; Cell Division; Cell Lineage; Cell Polarity/genetics; Chromosomes, Artificial, Yeast; Consensus Sequence; DNA, Complementary/genetics; Disorders of Sex Development; Drosophila Proteins; Drosophila melanogaster/genetics; Gene Expression Regulation; Genes, Reporter; Glycoproteins/chemistry; Glycoproteins/classification; Glycoproteins/genetics; Glycoproteins/physiology; Helminth Proteins/physiology; In Situ Hybridization; Mice; Molecular Sequence Data; Mosaicism; Multigene Family; Phenotype; Proto-Oncogene Proteins/chemistry; Proto-Oncogene Proteins/genetics; Recombinant Fusion Proteins/biosynthesis; Recombinant Fusion Proteins/genetics; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Tail; Wnt1 Protein