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Ausin, I, Mockler, TC, Chory, J and Jacobsen, SE (2009) IDN1 and IDN2 are required for de novo DNA methylation in Arabidopsis thaliana. Nat. Struct. Mol. Biol. 16:1325-7


DNA methylation is an epigenetic mark affecting genes and transposons. Screening for mutants that fail to establish DNA methylation yielded two we termed "involved in de novo" (idn) 1 and 2. IDN1 encodes DMS3, an SMC-related protein, and IDN2 encodes a previously unknown double-stranded RNA-binding protein with homology to SGS3. IDN1 and IDN2 control de novo methylation and small interfering RNA (siRNA)-mediated maintenance methylation and are components of the RNA-directed DNA methylation pathway.


PubMed PMC2842998 Online version:10.1038/nsmb.1690


Arabidopsis/physiology; Arabidopsis Proteins/genetics; Arabidopsis Proteins/physiology; Chromosomal Proteins, Non-Histone/genetics; Chromosomal Proteins, Non-Histone/physiology; DNA Methylation; RNA-Binding Proteins/genetics; RNA-Binding Proteins/physiology