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Willecke, M, Hamaratoglu, F, Kango-Singh, M, Udan, R, Chen, CL, Tao, C, Zhang, X and Halder, G (2006) The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr. Biol. 16:2090-100


The Hippo tumor-suppressor pathway has emerged as a key signaling pathway that controls tissue size in Drosophila. Merlin, the Drosophila homolog of the human Neurofibromatosis type-2 (NF2) tumor-suppressor gene, and the related protein Expanded are the most upstream components of the Hippo pathway identified so far. However, components acting upstream of Expanded and Merlin, such as transmembrane receptors, have not yet been identified.


PubMed Online version:10.1016/j.cub.2006.09.005


Animals; Cadherins/genetics; Cadherins/physiology; Cell Adhesion Molecules/genetics; Cell Adhesion Molecules/physiology; Cell Proliferation; Drosophila/embryology; Drosophila/genetics; Drosophila/physiology; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Eye/embryology; Eye/ultrastructure; Intracellular Signaling Peptides and Proteins; Membrane Proteins/metabolism; Neurofibromin 2/metabolism; Nuclear Proteins/metabolism; Phenotype; Protein Kinases/metabolism; Protein-Serine-Threonine Kinases/metabolism; Signal Transduction; Trans-Activators/metabolism; Wing/anatomy & histology