GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

TableEdit

Jump to: navigation, search

PMID:18660806

You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor

Citation

Kwon, Y, Shim, HS, Wang, X and Montell, C (2008) Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat. Neurosci. 11:871-3

Abstract

In animals such as the fruitfly, even minor deviations in environmental temperature can have major impacts on development and lifespan. Here we demonstrated that the ability of Drosophila melanogaster larvae to discriminate between the optimal temperature of 18 degrees C and slightly higher temperatures (19-24 degrees C) depended on the TRPA1 channel, which functioned downstream of a phospholipase C-dependent signaling cascade similar to that used in fly phototransduction. We propose that activation of TRPA1 through a signaling cascade promotes amplification of small differences in temperature and facilitates adaptation to temperatures within the comfortable range.

Links

PubMed Online version:10.1038/nn.2170

Keywords

Adaptation, Physiological/genetics; Adaptation, Physiological/physiology; Animals; Animals, Genetically Modified; Behavior, Animal; Choice Behavior/physiology; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/genetics; Drosophila melanogaster/physiology; Larva/genetics; Larva/physiology; Motor Activity/genetics; Motor Activity/physiology; Mutagenesis; Signal Transduction/genetics; Signal Transduction/physiology; TRPC Cation Channels/genetics; TRPC Cation Channels/metabolism; Temperature; Type C Phospholipases/metabolism

public



Cancel