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Sun, T, Echelard, Y, Lu, R, Yuk, DI, Kaing, S, Stiles, CD and Rowitch, DH (2001) Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Curr. Biol. 11:1413-20


Organizing signals such as Sonic hedgehog are thought to specify neuronal subtype identity by regulating the expression of homeodomain proteins in progenitors of the embryonic neural tube. One of these, Nkx2.2, is necessary and sufficient for the development of V3 interneurons.




Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Gene Expression; Helix-Loop-Helix Motifs; High Mobility Group Proteins/genetics; High Mobility Group Proteins/metabolism; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Mice; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Neurons/cytology; Neurons/metabolism; SOXE Transcription Factors; Stem Cells/cytology; Stem Cells/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism