GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
Kurosu, H, Ogawa, Y, Miyoshi, M, Yamamoto, M, Nandi, A, Rosenblatt, KP, Baum, MG, Schiavi, S, Hu, MC, Moe, OW and Kuro-o, M (2006) Regulation of fibroblast growth factor-23 signaling by klotho. J. Biol. Chem. 281:6120-3
The aging suppressor gene Klotho encodes a single-pass transmembrane protein. Klotho-deficient mice exhibit a variety of aging-like phenotypes, many of which are similar to those observed in fibroblast growth factor-23 (FGF23)-deficient mice. To test the possibility that Klotho and FGF23 may function in a common signal transduction pathway(s), we investigated whether Klotho is involved in FGF signaling. Here we show that Klotho protein directly binds to multiple FGF receptors (FGFRs). The Klotho-FGFR complex binds to FGF23 with higher affinity than FGFR or Klotho alone. In addition, Klotho significantly enhanced the ability of FGF23 to induce phosphorylation of FGF receptor substrate and ERK in various types of cells. Thus, Klotho functions as a cofactor essential for activation of FGF signaling by FGF23.
Animals; Cell Line; Fibroblast Growth Factors/deficiency; Fibroblast Growth Factors/genetics; Fibroblast Growth Factors/metabolism; Glucuronidase/genetics; Glucuronidase/physiology; HeLa Cells; Humans; Mice; Mice, Knockout; PC12 Cells; Rats; Receptors, Fibroblast Growth Factor/metabolism; Signal Transduction/genetics; Signal Transduction/physiology