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Gräf, R, Daunderer, C and Schulz, I (2004) Molecular and functional analysis of the dictyostelium centrosome. Int. Rev. Cytol. 241:155-202


The centrosome is a nonmembranous, nucleus-associated organelle that functions not only as the main microtubule-organizing center but also as a cell cycle control unit. How the approximately 100 different proteins that make up a centrosome contribute to centrosome function is still largely unknown. Considerable progress in the understanding of centrosomal functions can be expected from comparative cell biology of morphologically different centrosomal structures fulfilling conserved functions. Dictyostelium is an alternative model organism for centrosome research in addition to yeast and animal cells. With the elucidation of morphological changes and dynamics of centrosome duplication, the establishment of a centrosome isolation protocol, and the identification of many centrosomal components, there is a solid basis for understanding the biogenesis and function of this fascinating organelle. Here we give an overview of the prospective protein inventory of the Dictyostelium centrosome based on database searches. Moreover, we focus on the comparative cell biology of known components of the Dictyostelium centrosome including the gamma-tubulin complex and the homologues of centrin, Nek2, XMAP215, and EB1.


PubMed Online version:10.1016/S0074-7696(04)41003-1


Animals; Cell Cycle/physiology; Centrosome/metabolism; Centrosome/ultrastructure; Cytokinesis/physiology; Dictyostelium/genetics; Dictyostelium/metabolism; Dictyostelium/ultrastructure; Microtubule-Associated Proteins/metabolism; Microtubule-Organizing Center/metabolism; Microtubule-Organizing Center/ultrastructure; Protein-Serine-Threonine Kinases/metabolism; Trimethoprim-Sulfamethoxazole Combination/metabolism; Tubulin/metabolism; Xenopus Proteins/metabolism