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Pinto, JP, Conceição, NM, Viegas, CS, Leite, RB, Hurst, LD, Kelsh, RN and Cancela, ML (2005) Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro. J. Bone Miner. Res. 20:1440-53
The zebrafish runx2b transcription factor is an ortholog of RUNX2 and is highly conserved at the structural level. The runx2b pebp2alphaA2 isoform induces osteocalcin gene expression by binding to a specific region of the promoter and seems to have been selectively conserved in the teleost lineage.
Amino Acid Sequence; Animals; Conserved Sequence; Evolution, Molecular; Gene Expression Regulation; Genes, Reporter/genetics; Molecular Sequence Data; Osteocalcin/genetics; Phylogeny; Promoter Regions, Genetic; Protein Conformation; Protein Isoforms/classification; Protein Isoforms/genetics; Protein Isoforms/metabolism; Transcription Factors/classification; Transcription Factors/genetics; Transcription Factors/metabolism; Up-Regulation; Zebrafish/genetics; Zebrafish/metabolism; Zebrafish Proteins/classification; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism