GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com


Jump to: navigation, search


You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor


Sánchez-Nogueiro, J, Marín-García, P and Miras-Portugal, MT (2005) Characterization of a functional P2X(7)-like receptor in cerebellar granule neurons from P2X(7) knockout mice. FEBS Lett. 579:3783-8


The presence of ionotropic P2X(7) receptor has been studied in mice brain from wild type and P2X(7) receptor knockout animals. Western blot and immunocytochemical assays show the presence of a protein containing the P2X(7) immunogenic epitopes in the brain of knockout model. Reverse transcriptase polymerase chain reaction experiments demonstrate the absence of the disrupted sequence, but other sequences of P2X(7) specific mRNA expression have been detected. Functional calcium imaging experiments in cultured granule neurons from P2X(7) knockout cerebella show the existence of a functional P2X(7)-like receptor that keeps some of the properties of the genuine receptor.


PubMed Online version:10.1016/j.febslet.2005.05.073


Animals; Cerebellum/cytology; Mice; Mice, Knockout; Neurons/chemistry; Neurons/immunology; Neurons/metabolism; RNA, Messenger/analysis; RNA, Messenger/metabolism; Receptors, Purinergic P2/analysis; Receptors, Purinergic P2/genetics; Receptors, Purinergic P2/metabolism; Receptors, Purinergic P2X7