GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com


Jump to: navigation, search


You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor


Mackay, LK, Minnich, M, Kragten, NA, Liao, Y, Nota, B, Seillet, C, Zaid, A, Man, K, Preston, S, Freestone, D, Braun, A, Wynne-Jones, E, Behr, FM, Stark, R, Pellicci, DG, Godfrey, DI, Belz, GT, Pellegrini, M, Gebhardt, T, Busslinger, M, Shi, W, Carbone, FR, van Lier, RA, Kallies, A and van Gisbergen, KP (2016) Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes. Science 352:459-63


Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK cells, all of which share a common transcriptional program. Our results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations.


PubMed Online version:10.1126/science.aad2035


Animals; Gastrointestinal Tract/immunology; Gene Expression Regulation; Genes, Regulator/genetics; Genes, Regulator/physiology; Immunologic Memory/genetics; Kidney/immunology; Killer Cells, Natural/immunology; Liver/immunology; Lymphocyte Activation; Mice; Mice, Knockout; Natural Killer T-Cells/immunology; Positive Regulatory Domain I-Binding Factor 1; Skin/immunology; Transcription Factors/genetics; Transcription Factors/physiology; Transcription, Genetic; Up-Regulation