GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com


Jump to: navigation, search


You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki

See Help for Help on this wiki. See the documentation for how to use the table editor


Kenny, PJ, Zhou, H, Kim, M, Skariah, G, Khetani, RS, Drnevich, J, Arcila, ML, Kosik, KS and Ceman, S (2014) MOV10 and FMRP regulate AGO2 association with microRNA recognition elements. Cell Rep 9:1729-1741


The fragile X mental retardation protein FMRP regulates translation of its bound mRNAs through incompletely defined mechanisms. FMRP has been linked to the microRNA pathway, and we show here that it associates with the RNA helicase MOV10, also associated with the microRNA pathway. FMRP associates with MOV10 directly and in an RNA-dependent manner and facilitates MOV10's association with RNAs in brain and cells, suggesting a cooperative interaction. We identified the RNAs recognized by MOV10 using RNA immunoprecipitation and iCLIP. Examination of the fate of MOV10 on RNAs revealed a dual function for MOV10 in regulating translation: it facilitates microRNA-mediated translation of some RNAs, but it also increases expression of other RNAs by preventing AGO2 function. The latter subset was also bound by FMRP in close proximity to the MOV10 binding site, suggesting that FMRP prevents MOV10-mediated microRNA suppression. We have identified a mechanism for FMRP-mediated translational regulation through its association with MOV10.


PubMed PMC4268400 Online version:10.1016/j.celrep.2014.10.054


3' Untranslated Regions; Animals; Argonaute Proteins/metabolism; Binding Sites; Brain/metabolism; Fragile X Mental Retardation Protein/physiology; GC Rich Sequence; HEK293 Cells; Humans; Mice; Mice, Knockout; MicroRNAs/metabolism; Protein Binding; RNA Helicases/physiology; RNA Interference; Transcriptome