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Moreau, JF, Donaldson, DD, Bennett, F, Witek-Giannotti, J, Clark, SC and Wong, GG (1988) Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature 336:690-2


Leukaemia inhibitory factor (LIF) is a cytokine that induces macrophage differentiation of the murine M1 myeloid leukaemia cell line. We have isolated a cDNA clone encoding a novel human haemopoietic growth factor, human interleukin for DA cells (HILDA) that supports the proliferation of the murine interleukin-3-dependent leukaemic cell line, DA-la (refs 3-5). HILDA proved to be identical to LIF. The demonstration that the differentiation factor LIF will also serve as a growth factor for at least one myeloid leukaemic cell line provides further evidence that the distinction between growth-promoting and differentiation-inducing activities are largely determined by the target cell type.


PubMed Online version:10.1038/336690a0


Animals; Base Sequence; Cell Differentiation/drug effects; Cell Line; Growth Inhibitors/analysis; Humans; Interleukin-6; Interleukins/analysis; Leukemia Inhibitory Factor; Lymphokines; Molecular Sequence Data; Molecular Weight; Nucleic Acid Hybridization; Rats; Recombinant Proteins/analysis