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HUMAN:POTE1

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:2001032

regulation of double-strand break repair via nonhomologous end joining

PMID:29227966

ECO:0000314

P

Figure 2 POT1 promotes NHEJ fidelity but inhibits NHEJ efficiency

complete
CACAO 13287

protected

enables

GO:0061821

telomeric D-loop binding

PMID:19734539

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0002171)

Seeded From UniProt

complete

protected

involved_in

GO:0032212

positive regulation of telomere maintenance via telomerase

PMID:17237768

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0098505

G-rich strand telomeric DNA binding

PMID:17237768

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:1905774

regulation of DNA helicase activity

PMID:19734539

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_activity_of:(UniProtKB:P54132)

Seeded From UniProt

complete

protected

involved_in

GO:1905776

positive regulation of DNA helicase activity

PMID:19734539

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_activity_of:(UniProtKB:Q14191)

Seeded From UniProt

complete

protected

enables

GO:1905773

8-hydroxy-2'-deoxyguanosine DNA binding

PMID:19734539

ECO:0000314

direct assay evidence used in manual assertion

F

  • occurs_at:(GO:0000781)
  • has_input:(CHEBI:40304)
  • occurs_at:(SO:0002171)

Seeded From UniProt

complete

protected

enables

GO:1990955

G-rich single-stranded DNA binding

PMID:19734539

ECO:0000314

direct assay evidence used in manual assertion

F

  • occurs_at:(GO:0000781)
  • has_input:(CHEBI:40304)

Seeded From UniProt

complete

protected

enables

GO:0098505

G-rich strand telomeric DNA binding

PMID:22763445

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0070200

establishment of protein localization to telomere

PMID:25589350

ECO:0000315

mutant phenotype evidence used in manual assertion

P

transports_or_maintains_localization_of:(UniProtKB:Q9BQ15)|transports_or_maintains_localization_of:(UniProtKB:O14746)

Seeded From UniProt

complete

protected

involved_in

GO:0032210

regulation of telomere maintenance via telomerase

PMID:26586433

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q13315

P

Seeded From UniProt

complete

protected

NOT|enables

GO:0061849

telomeric G-quadruplex DNA binding

PMID:19734539

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0051973

positive regulation of telomerase activity

PMID:15181449

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:O14746)

Seeded From UniProt

complete

protected

part_of

GO:0070187

shelterin complex

PMID:15383534

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:19135898

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0061820

telomeric D-loop disassembly

PMID:22039056

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O94761

P

occurs_at:(GO:0000781)

Seeded From UniProt

complete

protected

part_of

GO:0070187

shelterin complex

PMID:23685356

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:23685356

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0042162

telomeric DNA binding

PMID:23685356

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0070187

shelterin complex

PMID:21852327

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:24270157

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0098505

G-rich strand telomeric DNA binding

PMID:21852327

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0060383

positive regulation of DNA strand elongation

PMID:16043710

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051974

negative regulation of telomerase activity

PMID:15632080

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051973

positive regulation of telomerase activity

PMID:17237768

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051973

positive regulation of telomerase activity

PMID:16043710

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051096

positive regulation of helicase activity

PMID:16030011

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0043047

single-stranded telomeric DNA binding

PMID:15632080

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0043047

single-stranded telomeric DNA binding

PMID:17237767

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0032508

DNA duplex unwinding

PMID:16030011

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032212

positive regulation of telomere maintenance via telomerase

PMID:12768206

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032212

positive regulation of telomere maintenance via telomerase

PMID:12781132

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032211

negative regulation of telomere maintenance via telomerase

PMID:15181449

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q96AP0

P

Seeded From UniProt

complete

protected

involved_in

GO:0032202

telomere assembly

PMID:16043710

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0017151

DEAD/H-box RNA helicase binding

PMID:16030011

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q14191

F

Seeded From UniProt

complete

protected

enables

GO:0017151

DEAD/H-box RNA helicase binding

PMID:16030011

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P54132

F

Seeded From UniProt

complete

protected

involved_in

GO:0016233

telomere capping

PMID:17632522

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q96AP0

P

Seeded From UniProt

complete

protected

involved_in

GO:0016233

telomere capping

PMID:15657433

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0010521

telomerase inhibitor activity

PMID:15632080

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0000783

nuclear telomere cap complex

PMID:16880378

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0043047

single-stranded telomeric DNA binding

PMID:12768206

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0007004

telomere maintenance via telomerase

PMID:12768206

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0000781

chromosome, telomeric region

PMID:12768206

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0098505

G-rich strand telomeric DNA binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000376531
PomBase:SPAC26H5.06
UniProtKB:Q9NUX5

F

Seeded From UniProt

complete

protected

involved_in

GO:0051974

negative regulation of telomerase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000376531
SGD:S000002379
UniProtKB:Q9NUX5

P

Seeded From UniProt

complete

protected

involved_in

GO:0032210

regulation of telomere maintenance via telomerase

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000376531
SGD:S000002379
UniProtKB:Q9NUX5

P

Seeded From UniProt

complete

protected

involved_in

GO:0016233

telomere capping

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1920086
PANTHER:PTN000376531
PomBase:SPAC26H5.06
SGD:S000002379
TAIR:locus:2164295
UniProtKB:Q9NUX5

P

Seeded From UniProt

complete

protected

enables

GO:0010521

telomerase inhibitor activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000376531
SGD:S000002379
UniProtKB:Q9NUX5

F

Seeded From UniProt

complete

protected

part_of

GO:0000783

nuclear telomere cap complex

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1920086
MGI:MGI:2141503
PANTHER:PTN000376531
UniProtKB:Q9NUX5

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0000723

telomere maintenance

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011564
InterPro:IPR028389

P

Seeded From UniProt

complete

protected

part_of

GO:0000784

nuclear chromosome, telomeric region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011564

C

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011564

F

Seeded From UniProt

complete

protected

enables

GO:0043047

single-stranded telomeric DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028389
InterPro:IPR032042

F

Seeded From UniProt

complete

protected

involved_in

GO:0016233

telomere capping

PMID:17237768
Reactome:R-HSA-181450
Reactome:R-HSA-176700

ECO:0000304

author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

protected

involved_in

GO:0032211

negative regulation of telomere maintenance via telomerase

PMID:17237768

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0070187

shelterin complex

PMID:17237768

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-3785711
Reactome:R-HSA-181450
Reactome:R-HSA-176700

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

protected

part_of

GO:0000781

chromosome, telomeric region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0779
UniProtKB-SubCell:SL-0276

C

Seeded From UniProt

complete

protected

part_of

GO:0005694

chromosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete




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