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HUMAN:MARH1

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

protected

enables

GO:0042287

MHC protein binding

PMID:18389477

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

public

GO:0000209

protein polyubiquitination

PMID:27577745

ECO:0000315

P

Figure 8C shows that wild-type MARCH1 polyubiquitinates INSR beta, while MARCH1 that is E3-ligase activity-defective does not. Figure 8D demonstrates that, in cells, knockdown of MARCH1 results in a decrease in INSR beta ubiquitination.

complete
CACAO 12111

protected

part_of

GO:0032588

trans-Golgi network membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6NZQ8

C

Seeded From UniProt

complete

protected

part_of

GO:0031902

late endosome membrane

PMID:19117940

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0031901

early endosome membrane

PMID:19117940

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0006955

immune response

PMID:18305173

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006955

immune response

PMID:18389477

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:19117940

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6NZQ8

C

Seeded From UniProt

complete

protected

part_of

GO:0005768

endosome

PMID:14722266

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005765

lysosomal membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6NZQ8

C

Seeded From UniProt

complete

protected

part_of

GO:0005764

lysosome

PMID:14722266

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:18389477

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:19117940

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:18305173

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:14722266

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0002495

antigen processing and presentation of peptide antigen via MHC class II

PMID:18389477

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000209

protein polyubiquitination

PMID:19117940

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0061630

ubiquitin protein ligase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

F

Seeded From UniProt

complete

protected

part_of

GO:0032588

trans-Golgi network membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

C

Seeded From UniProt

complete

protected

part_of

GO:0031902

late endosome membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

C

Seeded From UniProt

complete

protected

part_of

GO:0031901

early endosome membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

C

Seeded From UniProt

complete

protected

involved_in

GO:0006955

immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

P

Seeded From UniProt

complete

protected

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

C

Seeded From UniProt

complete

protected

part_of

GO:0005765

lysosomal membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

C

Seeded From UniProt

complete

protected

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

F

Seeded From UniProt

complete

protected

involved_in

GO:0002495

antigen processing and presentation of peptide antigen via MHC class II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

P

Seeded From UniProt

complete

protected

involved_in

GO:0000209

protein polyubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6NZQ8
ensembl:ENSMUSP00000136545

P

Seeded From UniProt

complete

protected

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011016

F

Seeded From UniProt

complete

protected

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

protected

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

protected

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

protected

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

protected

part_of

GO:0005764

lysosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0458

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

protected

part_of

GO:0031901

early endosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0093

C

Seeded From UniProt

complete

protected

part_of

GO:0031902

late endosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0151

C

Seeded From UniProt

complete

protected

part_of

GO:0030659

cytoplasmic vesicle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0089

C

Seeded From UniProt

complete

protected

part_of

GO:0005765

lysosomal membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0157

C

Seeded From UniProt

complete

protected

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete




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