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BPT1:SPANU

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0020002

host cell plasma membrane

PMID:11532126

C

Figure 3. "T4 T holin accumulates in the inner membrane [...]".

Missing: evidence
CACAO 10410

public

GO:0034291

canonical holin activity

PMID:11361346

UniProtKB:P03705


F

Figure 2A. and Figure 2B. show that the T4 protein "t" can complement the function of Lambda "S" holin gene.

Missing: evidence
CACAO 10421

public

GO:0044659

cytolysis by virus of host cell

PMID:17900620

UniProtKB:P00726 UniProtKB:Q37935


P

Figure 4. shows the function of T1 gp11 restore the function of lambda Rz and Rz1.

Missing: evidence
CACAO 10373

public

GO:0045203

integral component of cell outer membrane

PMID:17900620

UniProtKB:Q37935


C

The T1 gp11 was found to have a sequence that very likely predicts an outer membrane lipoprotein, just as Lambda Rz1 produces an outer membrane lipoprotein component of a spanin (p. 1098). In addition, many phages, including Lambda, have a lysis cassette, which means that the holin, endolysin, and spanin are all next to each other in the genome (p. 1100). In the case of T1, genes 12 and 13 are the endolysin and holin, respectively, providing further evidence that gp11 is an integral component of the cell outer membrane. (I've also requested a new GO term to use for gp11, since this paper indicates that the protein disrupts the outer membrane. The issue can be found here https://github.com/geneontology/go-ontology/issues/12424).

Missing: evidence
CACAO 11890

public

GO:0045918

negative regulation of cytolysis

PMID:30135120

ECO:0007699

cell growth assay evidence used in manual assertion

P

Fig. 4D shows GTG-to-GTC mutations in downstream alternative starts Val 63 and Val 65 cause early onset of lysis.

Isoform gp11a (Q6XQ97-2) V63M Isoform gp11a' (Q6XQ97-3) V65M

Organism: Escherichia phage T1 (Bacteriophage T1)

complete
CACAO 13777

public

GO:0044659

cytolysis by virus of host cell

PMID:30135120

ECO:0007699

cell growth assay evidence used in manual assertion

P

Fig 3B. shows PRE plasmids containing the gp11 U-spanin complement MC4100 ╬╗RzamRz1am lysogens to rescue the wt lysis phenotype.

Organism: Escherichia phage T1 (Bacteriophage T1)

complete
CACAO 13781

protected

part_of

GO:0020002

host cell plasma membrane

GO_REF:0000037
GO_REF:0000037
GO_REF:0000037
GO_REF:0000039
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1030
UniProtKB-KW:KW-1032
UniProtKB-KW:KW-1033
UniProtKB-SubCell:SL-0373
UniProtKB-SubCell:SL-0376

C

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

protected

involved_in

GO:0019835

cytolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0204

P

Seeded From UniProt

complete

public

GO:0045203

integral component of cell outer membrane

PMID:17900620

ECO:0000317

genomic context evidence used in manual assertion

UniProtKB:Q37935

C

The T1 gp11 was found to have a sequence that very likely predicts an outer membrane lipoprotein, just as Lambda Rz1 produces an outer membrane lipoprotein component of a spanin (p. 1098). In addition, many phages, including Lambda, have a lysis cassette, which means that the holin, endolysin, and spanin are all next to each other in the genome (p. 1100). In the case of T1, genes 12 and 13 are the endolysin and holin, respectively, providing further evidence that gp11 is an integral component of the cell outer membrane. (I've also requested a new GO term to use for gp11, since this paper indicates that the protein disrupts the outer membrane. The issue can be found here https://github.com/geneontology/go-ontology/issues/12424).

complete

protected

part_of

GO:0033644

host cell membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1043

C

Seeded From UniProt

complete

public

GO:0090680

disruption by virus of host outer membrane

PMID:17900620

ECO:0000317

genomic context evidence used in manual assertion

P

Missing: with/from

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete




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