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HUMAN:LIF

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0033630

positive regulation of cell adhesion mediated by integrin

PMID:26723254

ECO:0000315

P

Figs 2,3

complete
CACAO 11257

public

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:26723254

ECO:0000314

P

Figure 1 shows increased integrin expression (higher levels of integrin mRNA)

complete
CACAO 11522

public

GO:0033630

positive regulation of cell adhesion mediated by integrin

PMID:26723254

ECO:0000315

P

As shown in Fig. 2B, LIF increased the adhesion of the human trophectoderm-derived JAr cells to endometrial Ishikawa cells. On the contrary, hLA diminished the adhesion of JAr cells to LIF-stimulated Ishikawa cells. These results suggest that the enhancement of integrin αV, β3, and β5 by LIF might be associated with the adhesion of trophblast to endometrium for embryo implantation. Figure 2A shows adhesion is dependent on integrins. (hLa inhibits LIF, hence IMP) Figure 3 uses antibodies to neutralize the integrins.

complete
CACAO 11523

public

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:26723254

ECO:0000315

P

Figure 2A Treatment of hLA (inhibitor of LIF) clearly resulted in the reduction of ITGAV, ITGB3 and ITGB5 expression levels induced by LIF in the Ishikawa cells

complete
CACAO 11524

protected

involved_in

GO:1901676

positive regulation of histone H3-K27 acetylation

PMID:22783022

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1900182

positive regulation of protein localization to nucleus

PMID:22783022

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0072307

regulation of metanephric nephron tubule epithelial cell differentiation

PMID:20624457

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0072108

positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

PMID:20624457

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048861

leukemia inhibitory factor signaling pathway

PMID:12643274

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048861

leukemia inhibitory factor signaling pathway

PMID:8999038

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:22783022

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20624457

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

PMID:20624457

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0033141

positive regulation of peptidyl-serine phosphorylation of STAT protein

PMID:20624457

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:8999038

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0008083

growth factor activity

PMID:12643274

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0008083

growth factor activity

PMID:8999038

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:12643274

ECO:0000305

curator inference used in manual assertion

GO:0008083

C

Seeded From UniProt

complete

protected

enables

GO:0005146

leukemia inhibitory factor receptor binding

PMID:8999038

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P40189

F

Seeded From UniProt

complete

protected

enables

GO:0005102

signaling receptor binding

PMID:8999038

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P42702

F

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

PMID:22783022

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0048861

leukemia inhibitory factor signaling pathway

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000067074
UniProtKB:P15018

P

Seeded From UniProt

complete

protected

involved_in

GO:0045595

regulation of cell differentiation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96787
PANTHER:PTN000067074

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96787
PANTHER:PTN000067074
UniProtKB:P15018

P

Seeded From UniProt

complete

protected

enables

GO:0008083

growth factor activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96787
PANTHER:PTN000067074
UniProtKB:P15018

F

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000067074
RGD:620865

C

Seeded From UniProt

complete

protected

enables

GO:0005146

leukemia inhibitory factor receptor binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000067074
RGD:620865
UniProtKB:P15018

F

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96787
PANTHER:PTN000067074
UniProtKB:P15018

F

Seeded From UniProt

complete

protected

involved_in

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

PMID:7508917

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0046888

negative regulation of hormone secretion

PMID:7867561

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:7508917

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045651

positive regulation of macrophage differentiation

PMID:7957045

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043410

positive regulation of MAPK cascade

PMID:7508917

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

PMID:7508917

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:7957045

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0008083

growth factor activity

PMID:7957045

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0005146

leukemia inhibitory factor receptor binding

PMID:7957045

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

PMID:7957045

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

protected

involved_in

GO:1903025

regulation of RNA polymerase II regulatory region sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0070373

negative regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0060708

spongiotrophoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0060707

trophoblast giant cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0060463

lung lobe morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0060426

lung vasculature development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0060135

maternal process involved in female pregnancy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0048863

stem cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0048711

positive regulation of astrocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0048666

neuron development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0048644

muscle organ morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0048286

lung alveolus development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0046697

decidualization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0045835

negative regulation of meiotic nuclear division

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0045595

regulation of cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0030324

lung development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0019827

stem cell population maintenance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

enables

GO:0008083

growth factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

F

Seeded From UniProt

complete

protected

involved_in

GO:0007566

embryo implantation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

involved_in

GO:0007260

tyrosine phosphorylation of STAT protein

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

F

Seeded From UniProt

complete

protected

involved_in

GO:0001974

blood vessel remodeling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P09056
ensembl:ENSMUSP00000067066

P

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001581
InterPro:IPR019827

F

Seeded From UniProt

complete

protected

enables

GO:0005146

leukemia inhibitory factor receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003624

F

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001581
InterPro:IPR003624
InterPro:IPR019827

C

Seeded From UniProt

complete

protected

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001581
InterPro:IPR019827

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:3143918

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007275

multicellular organism development

PMID:3143918

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0019221

cytokine-mediated signaling pathway

Reactome:R-HSA-6785807
Reactome:R-HSA-6783783
Reactome:R-HSA-6783589

ECO:0000304

author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6789615
Reactome:R-HSA-6784160
Reactome:R-HSA-6783681
Reactome:R-HSA-6783524

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

protected

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete




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