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HUMAN:TNFA

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

protected

involved_in

GO:1903078

positive regulation of protein localization to plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

  • regulates_o_occurs_in:(CL:0002608)
  • occurs_in:(CL:0000127)
  • has_regulation_target:(UniProtKB:P42261)
  • has_target_end_location:(GO:0097060)

Seeded From UniProt

complete

protected

involved_in

GO:0090197

positive regulation of chemokine secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

  • occurs_in:(CL:0002539)
  • has_regulation_target:(UniProtKB:O55145)

Seeded From UniProt

complete

protected

involved_in

GO:0051897

positive regulation of protein kinase B signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

  • occurs_in:(CL:0002539)
  • positively_regulates:(GO:0007249)

Seeded From UniProt

complete

protected

involved_in

GO:0050754

positive regulation of fractalkine biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

  • occurs_in:(CL:0002539)
  • has_regulation_target:(UniProtKB:O55145)

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

  • positively_regulates:(GO:0035425)
  • occurs_in:(CL:0002539)
  • regulates_expression_of:(ENSEMBL:ENSRNOG00000016326)|positively_regulates(GO:0035425)
  • occurs_in:(CL:0002539)
  • regulates_expression_of:(ENSEMBL:ENSRNOG00000018509)

Seeded From UniProt

complete

protected

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

  • occurs_in:(CL:0002539)
  • positively_regulates:(GO:0050751)

Seeded From UniProt

complete

protected

involved_in

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

  • occurs_in:(CL:0002539)
  • positively_regulates:(GO:0007249)

Seeded From UniProt

complete

protected

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

  • part_of:(GO:0043123)
  • occurs_in:(CL:0002539)

Seeded From UniProt

complete

protected

involved_in

GO:0050806

positive regulation of synaptic transmission

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

regulates_o_occurs_in:(CL:0002608)

Seeded From UniProt

complete

protected

involved_in

GO:0051000

positive regulation of nitric-oxide synthase activity

PMID:29702085

ECO:0000305

curator inference used in manual assertion

GO:0010628

P

  • regulates_o_occurs_in:(CL:0000129)
  • occurs_in:(CL:2000043)
  • has_regulation_target:(UniProtKB:P35228)

Seeded From UniProt

complete

protected

involved_in

GO:2000778

positive regulation of interleukin-6 secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

regulates_o_occurs_in:(CL:2000043)|regulates_o_occurs_in:(CL:0000127)

Seeded From UniProt

complete

protected

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

  • regulates_o_occurs_in:(CL:2000043)
  • has_regulation_target:(UniProtKB:Q04206)
  • positively_regulates:(GO:0042226)|regulates_o_occurs_in(CL:0000127)
  • has_regulation_target:(UniProtKB:Q04206)

Seeded From UniProt

complete

protected

involved_in

GO:0046427

positive regulation of receptor signaling pathway via JAK-STAT

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

  • regulates_o_occurs_in:(CL:2000043)
  • positively_regulates:(GO:0072604)

Seeded From UniProt

complete

protected

involved_in

GO:0045410

positive regulation of interleukin-6 biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

regulates_o_occurs_in:(CL:2000043)

Seeded From UniProt

complete

protected

involved_in

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

  • regulates_o_occurs_in:(CL:2000043)
  • has_regulation_target:(UniProtKB:P40763)
  • positively_regulates:(GO:0072604)

Seeded From UniProt

complete

protected

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

  • regulates_o_occurs_in:(CL:2000043)
  • has_regulation_target:(UniProtKB:Q04206)
  • positively_regulates:(GO:0072604)
  • part_of:(GO:0051092)

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

  • regulates_o_occurs_in:(CL:0000129)
  • occurs_in:(CL:2000043)
  • regulates_expression_of:(ENSEMBL:ENSG00000007171)

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P16599

P

  • regulates_o_occurs_in:(CL:2000043)
  • part_of:(GO:0045410)
  • regulates_expression_of:(ENSEMBL:ENSG00000136244)

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:24299952

ECO:0000316

genetic interaction evidence used in manual assertion

RNAcentral:URS00001C770D_9606

P

  • occurs_in:(CL:0002618)
  • regulates_expression_of:(ENSEMBL:ENSG00000100985)

Seeded From UniProt

complete

protected

involved_in

GO:0032755

positive regulation of interleukin-6 production

PMID:24299952

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0002618)

Seeded From UniProt

complete

protected

involved_in

GO:0010629

negative regulation of gene expression

PMID:24299952

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q16539

P

  • regulates_expression_of:(ENSEMBL:ENSG00000207611)
  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06804

P

  • regulates_o_occurs_in:(CL:0000129)
  • regulates_expression_of:(ENSEMBL:ENSG00000135218)|regulates_o_occurs_in(CL:0000129)
  • regulates_expression_of:(ENSEMBL:ENSG00000119912)

Seeded From UniProt

complete

protected

involved_in

GO:0045598

regulation of fat cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P23563

P

  • occurs_in:(CL:0000136)
  • regulates_o_occurs_in:(CL:0000136)

Seeded From UniProt

complete

protected

involved_in

GO:0043525

positive regulation of neuron apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06804

P

part_of:(GO:0001774)

Seeded From UniProt

complete

protected

involved_in

GO:0001774

microglial cell activation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06804

P

Seeded From UniProt

complete

protected

involved_in

GO:1903078

positive regulation of protein localization to plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06804

P

  • regulates_o_occurs_in:(CL:0002608)
  • has_regulation_target:(UniProtKB:P42261)
  • has_target_end_location:(GO:0097060)
  • occurs_in:(CL:0000125)

Seeded From UniProt

complete

protected

involved_in

GO:0050807

regulation of synapse organization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06804

P

  • regulates_o_occurs_in:(UBERON:0002421)
  • occurs_in:(UBERON:0002421)
  • occurs_in:(CL:0000125)
  • regulates_o_occurs_in:(CL:0002608)

Seeded From UniProt

complete

protected

involved_in

GO:0050806

positive regulation of synaptic transmission

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06804

P

  • regulates_o_occurs_in:(UBERON:0002421)
  • occurs_in:(UBERON:0002421)
  • occurs_in:(CL:0000125)
  • regulates_o_occurs_in:(CL:0002608)

Seeded From UniProt

complete

protected

involved_in

GO:0060252

positive regulation of glial cell proliferation

PMID:1752215

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P01584

P

results_in_division_of:(CL:0000129)|results_in_division_of:(CL:0000127)

Seeded From UniProt

complete

protected

involved_in

GO:0060252

positive regulation of glial cell proliferation

PMID:2104886

ECO:0000314

direct assay evidence used in manual assertion

P

results_in_division_of:(CL:0000127)

Seeded From UniProt

complete

protected

involved_in

GO:2000351

regulation of endothelial cell apoptotic process

PMID:10843670

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(CL:0000576)
  • regulates_o_occurs_in:(CL:2000008)

Seeded From UniProt

complete

protected

enables

GO:0005164

tumor necrosis factor receptor binding

PMID:9435233

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P19438
UniProtKB:P20333

F

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:21323571

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001977)

Seeded From UniProt

complete

protected

involved_in

GO:0045732

positive regulation of protein catabolic process

PMID:18632959

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q08353)

Seeded From UniProt

complete

protected

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:25193116

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:26371161

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSG00000090339)
  • occurs_in:(CL:0002618)|regulates_expression_of(ENSEMBL:ENSG00000162692)
  • occurs_in:(CL:0002618)|regulates_expression_of(ENSEMBL:ENSG00000007908)
  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:11085990

ECO:0000314

direct assay evidence used in manual assertion

P

  • has_regulation_target:(UniProtKB:P81534)
  • occurs_in:(CL:0000312)|has_regulation_target(UniProtKB:P81534)
  • occurs_in:(CL:0000307)

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:23892569

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • has_regulation_target:(UniProtKB:Q9UNG2)
  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

protected

involved_in

GO:0045785

positive regulation of cell adhesion

PMID:23892569

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:23817958

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(CL:0000134)
  • has_regulation_target:(UniProtKB:O00182)

Seeded From UniProt

complete

protected

involved_in

GO:1903140

regulation of establishment of endothelial barrier

PMID:25816133

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:9343261

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:16203728

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(CL:0000576)
  • has_regulation_target:(UniProtKB:Q96RT1)

Seeded From UniProt

complete

protected

involved_in

GO:0072659

protein localization to plasma membrane

PMID:25816133

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(CL:2000008)
  • causally_upstream_of:(GO:1903140)
  • has_regulation_target:(UniProtKB:O00501)
  • has_input:(UniProtKB:P19438)
  • has_input:(UniProtKB:O14920)
  • has_input:(UniProtKB:Q13464)
  • results_in_development_of:(GO:0005923)

Seeded From UniProt

complete

protected

involved_in

GO:0035509

negative regulation of myosin-light-chain-phosphatase activity

PMID:25816133

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(CL:2000008)
  • causally_upstream_of:(GO:1903140)
  • has_regulation_target:(UniProtKB:Q13464)

Seeded From UniProt

complete

protected

involved_in

GO:0030866

cortical actin cytoskeleton organization

PMID:25816133

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1903347

negative regulation of bicellular tight junction assembly

PMID:25816133

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1901224

positive regulation of NIK/NF-kappaB signaling

PMID:20041225

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P23396)

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:24998411

ECO:0000314

direct assay evidence used in manual assertion

P

  • has_regulation_target:(RNAcentral:URS000013D17D_9606)
  • occurs_in:(CL:0000071)

Seeded From UniProt

complete

protected

involved_in

GO:1901671

positive regulation of superoxide dismutase activity

PMID:22836756

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P04179)

Seeded From UniProt

complete

protected

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:24790089

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_input:(UniProtKB:Q9HC29)

Seeded From UniProt

complete

protected

involved_in

GO:0045860

positive regulation of protein kinase activity

PMID:11821416

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:O14920)

Seeded From UniProt

complete

protected

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:11821416

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:11374864

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050766

positive regulation of phagocytosis

PMID:18201371

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • part_of:(GO:0007249)
  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

protected

involved_in

GO:0010629

negative regulation of gene expression

PMID:22267480

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSG00000164867)
  • occurs_in:(CL:1000413)

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:22267480

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSG00000007908)
  • occurs_in:(CL:1000413)

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:22267480

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSG00000162692)
  • occurs_in:(CL:1000413)

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:22267480

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSG00000108691)
  • occurs_in:(CL:1000413)

Seeded From UniProt

complete

protected

involved_in

GO:1904999

positive regulation of leukocyte adhesion to arterial endothelial cell

PMID:22267480

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006954

inflammatory response

PMID:22267480

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:1000413)

Seeded From UniProt

complete

protected

involved_in

GO:1904996

positive regulation of leukocyte adhesion to vascular endothelial cell

PMID:26371161

ECO:0000314

direct assay evidence used in manual assertion

P

  • has_agent:(CL:0002618)
  • has_agent:(CL:0000775)

Seeded From UniProt

complete

protected

involved_in

GO:0010629

negative regulation of gene expression

PMID:26371161

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSG00000207708)
  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:26371161

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSG00000253522)
  • occurs_in:(CL:0002618)|regulates_expression_of(ENSEMBL:ENSG00000234883)
  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

protected

involved_in

GO:0048143

astrocyte activation

PMID:26753638

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0001774

microglial cell activation

PMID:26753638

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:24998411

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSG00000117525)
  • occurs_in:(CL:0000071)

Seeded From UniProt

complete

protected

involved_in

GO:2000334

positive regulation of blood microparticle formation

PMID:24998411

ECO:0000314

direct assay evidence used in manual assertion

P

has_agent:(CL:0000071)

Seeded From UniProt

complete

protected

involved_in

GO:0032757

positive regulation of interleukin-8 production

PMID:24790089

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_input:(UniProtKB:Q9HC29)

Seeded From UniProt

complete

protected

involved_in

GO:0048566

embryonic digestive tract development

PMID:20875417

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:21559518

ECO:0000314

direct assay evidence used in manual assertion

P

has_input:(UniProtKB:Q9H6S0)

Seeded From UniProt

complete

protected

involved_in

GO:2001240

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

PMID:10666185

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:2001240

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

PMID:10748004

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:2000343

positive regulation of chemokine (C-X-C motif) ligand 2 production

PMID:20551324

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:2000010

positive regulation of protein localization to cell surface

PMID:19366699

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P16581)

Seeded From UniProt

complete

protected

involved_in

GO:0097527

necroptotic signaling pathway

PMID:11101870

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0071803

positive regulation of podosome assembly

PMID:15220135

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0071677

positive regulation of mononuclear cell migration

PMID:21319131

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:18606301

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0060559

positive regulation of calcidiol 1-monooxygenase activity

PMID:1690216

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0060557

positive regulation of vitamin D biosynthetic process

PMID:1690216

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0055037

recycling endosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06804

C

Seeded From UniProt

complete

protected

involved_in

GO:0051384

response to glucocorticoid

PMID:10443688

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051222

positive regulation of protein transport

PMID:15310755

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

public

GO:0010874

regulation of cholesterol efflux

PMID:23914732

ECO:0000314

P

Figure 1: Human macrophages were labeled with 3H-cholesterol. TNFa was added to the cell cultures in increasing doses. apoA-I or HDL were added. The figures show that cholesterol efflux decreased in a dose-dependent manner in cells treated with TNFa.

complete
CACAO 9395

protected

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:10383454

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:20551324

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

public

GO:0010468

regulation of gene expression

PMID:23914732

ECO:0000314

P

Figure 1A: Human macrophages were treated with increasing doses of TNFa. Using PCR, the levels of mRNA were measured. As the dose of mRNA increased, the level of ABCA1 mRNA decreased.

complete
CACAO 9396

protected

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

PMID:10748004

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051044

positive regulation of membrane protein ectodomain proteolysis

PMID:18373975

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050995

negative regulation of lipid catabolic process

PMID:19032770

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050901

leukocyte tethering or rolling

PMID:10820279

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050796

regulation of insulin secretion

PMID:8383325

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050715

positive regulation of cytokine secretion

PMID:10443688

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0048661

positive regulation of smooth muscle cell proliferation

PMID:16518841

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20551324

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_transcription_of:(ENSEMBL:ENSG00000162692)
  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

protected

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:14512626

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:10748004

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045672

positive regulation of osteoclast differentiation

PMID:17888176

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045599

negative regulation of fat cell differentiation

PMID:16464856

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045429

positive regulation of nitric oxide biosynthetic process

PMID:8383325

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045416

positive regulation of interleukin-8 biosynthetic process

PMID:20551324

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0045121

membrane raft

PMID:17010968

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0045080

positive regulation of chemokine biosynthetic process

PMID:10490959

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045071

negative regulation of viral genome replication

PMID:10490959

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043406

positive regulation of MAP kinase activity

PMID:12813029

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043406

positive regulation of MAP kinase activity

PMID:18440775

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0002618)

Seeded From UniProt

complete

protected

involved_in

GO:0043243

positive regulation of protein complex disassembly

PMID:12813029

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:15310755

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:17922812

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043122

regulation of I-kappaB kinase/NF-kappaB signaling

PMID:10748004

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:14512626

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:1901224

positive regulation of NIK/NF-kappaB signaling

PMID:17922812

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0034116

positive regulation of heterotypic cell-cell adhesion

PMID:20551324

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0034116

positive regulation of heterotypic cell-cell adhesion

PMID:10604883

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0033209

tumor necrosis factor-mediated signaling pathway

PMID:10748004

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

PMID:17389591

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

PMID:18440775

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0002618)

Seeded From UniProt

complete

protected

involved_in

GO:0032800

receptor biosynthetic process

PMID:10443688

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032722

positive regulation of chemokine production

PMID:10490959

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032715

negative regulation of interleukin-6 production

PMID:10443688

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0031622

positive regulation of fever generation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06804

P

Seeded From UniProt

complete

protected

involved_in

GO:0031334

positive regulation of protein complex assembly

PMID:12813029

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030730

sequestering of triglyceride

PMID:19032770

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0010888

negative regulation of lipid storage

PMID:16464856

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0009986

cell surface

PMID:18355445

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0009897

external side of plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06804

C

Seeded From UniProt

complete

protected

involved_in

GO:0009615

response to virus

PMID:10490959

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

PMID:10521396

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

PMID:18202225

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

PMID:21319131

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006954

inflammatory response

PMID:10748004

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

PMID:18355445

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:18355445

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:10443688

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:3932069

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0005164

tumor necrosis factor receptor binding

PMID:14512626

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

PMID:10748004

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0002740

negative regulation of cytokine secretion involved in immune response

PMID:10443688

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0002439

chronic inflammatory response to antigenic stimulus

PMID:14512626

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0002020

protease binding

PMID:12777399

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P78325

F

Seeded From UniProt

complete

protected

involved_in

GO:0001934

positive regulation of protein phosphorylation

PMID:10748004

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0001891

phagocytic cup

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P06804

C

Seeded From UniProt

complete

protected

involved_in

GO:0001819

positive regulation of cytokine production

PMID:17922812

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000187

activation of MAPK activity

PMID:10748004

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000185

activation of MAPKKK activity

PMID:15310755

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0097527

necroptotic signaling pathway

PMID:22817896

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0097527

necroptotic signaling pathway

PMID:22265413

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0097527

necroptotic signaling pathway

PMID:22265414

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0097191

extrinsic apoptotic signaling pathway

PMID:11577081

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0097191

extrinsic apoptotic signaling pathway

PMID:16611992

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0071407

cellular response to organic cyclic compound

PMID:21147091

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:1000742)

Seeded From UniProt

complete

protected

involved_in

GO:0071316

cellular response to nicotine

PMID:18676776

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0061048

negative regulation of branching involved in lung morphogenesis

PMID:17350185

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:16611992

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:16280327

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15345745

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P24387)

Seeded From UniProt

complete

protected

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:17350185

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:16895791

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:17350185

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0044212

transcription regulatory region DNA binding

PMID:17350185

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0043507

positive regulation of JUN kinase activity

PMID:17389591

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043491

protein kinase B signaling

PMID:21147091

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:1000742)

Seeded From UniProt

complete

protected

involved_in

GO:0043406

positive regulation of MAP kinase activity

PMID:17389591

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:11577081

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043243

positive regulation of protein complex disassembly

PMID:17389591

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043242

negative regulation of protein complex disassembly

PMID:17389591

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043068

positive regulation of programmed cell death

PMID:16611992

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:17389591

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:16723520

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:22173242

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0031663

lipopolysaccharide-mediated signaling pathway

PMID:21147091

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:1000742)

Seeded From UniProt

complete

protected

involved_in

GO:0010629

negative regulation of gene expression

PMID:15345745

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q60571)

Seeded From UniProt

complete

protected

involved_in

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

PMID:18676776

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006954

inflammatory response

PMID:21147091

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:1000742)

Seeded From UniProt

complete

protected

involved_in

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16723520

ECO:0000314

direct assay evidence used in manual assertion

P

has_input:(UniProtKB:P42574)|has_input:(UniProtKB:Q14790)

Seeded From UniProt

complete

protected

involved_in

GO:0001934

positive regulation of protein phosphorylation

PMID:17389591

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0001934

positive regulation of protein phosphorylation

PMID:16723520

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000165

MAPK cascade

PMID:21147091

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:1000742)

Seeded From UniProt

complete

protected

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:15345745

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P03372)|has_input(UniProtKB:P24387)

Seeded From UniProt

complete

protected

involved_in

GO:0070886

positive regulation of calcineurin-NFAT signaling cascade

PMID:16803872

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:15790681

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:16803872

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q8K120

P

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

PMID:12594207

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:1618860

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:2922050

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P01375

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:23815148

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P01375

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:19838188

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P01375

F

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:2000377

regulation of reactive oxygen species metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:1904707

positive regulation of vascular smooth muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:1903078

positive regulation of protein localization to plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:1901224

positive regulation of NIK/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0097527

necroptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0097191

extrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0097190

apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0072577

endothelial cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0071230

cellular response to amino acid stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0071222

cellular response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0060693

regulation of branching involved in salivary gland morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0060664

epithelial cell proliferation involved in salivary gland morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

part_of

GO:0055037

recycling endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

C

Seeded From UniProt

complete

protected

involved_in

GO:0051897

positive regulation of protein kinase B signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0051798

positive regulation of hair follicle development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0051023

regulation of immunoglobulin secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0050900

leukocyte migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0050830

defense response to Gram-positive bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0050807

regulation of synapse organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0050806

positive regulation of synaptic transmission

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0050727

regulation of inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0050708

regulation of protein secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0046330

positive regulation of JNK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0046325

negative regulation of glucose import

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0045994

positive regulation of translational initiation by iron

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0045930

negative regulation of mitotic cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0045670

regulation of osteoclast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0045668

negative regulation of osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0045662

negative regulation of myoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0045123

cellular extravasation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

part_of

GO:0045121

membrane raft

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

C

Seeded From UniProt

complete

protected

involved_in

GO:0044130

negative regulation of growth of symbiont in host

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0043525

positive regulation of neuron apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0042742

defense response to bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0042127

regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0034116

positive regulation of heterotypic cell-cell adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0033209

tumor necrosis factor-mediated signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0032755

positive regulation of interleukin-6 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0032729

positive regulation of interferon-gamma production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0031622

positive regulation of fever generation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0030316

osteoclast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0030198

extracellular matrix organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0010693

negative regulation of alkaline phosphatase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0010629

negative regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0010033

response to organic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

part_of

GO:0009897

external side of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

C

Seeded From UniProt

complete

protected

involved_in

GO:0009887

animal organ morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0007275

multicellular organism development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0007254

JNK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0006959

humoral immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0006954

inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0006952

defense response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0006006

glucose metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

C

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

C

Seeded From UniProt

complete

protected

enables

GO:0005164

tumor necrosis factor receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

F

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

F

Seeded From UniProt

complete

protected

involved_in

GO:0002925

positive regulation of humoral immune response mediated by circulating immunoglobulin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0002876

positive regulation of chronic inflammatory response to antigenic stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

enables

GO:0002020

protease binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

F

Seeded From UniProt

complete

protected

involved_in

GO:0001937

negative regulation of endothelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0001932

regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

part_of

GO:0001891

phagocytic cup

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

C

Seeded From UniProt

complete

protected

involved_in

GO:0001774

microglial cell activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06804
ensembl:ENSMUSP00000025263

P

Seeded From UniProt

complete

protected

enables

GO:0005164

tumor necrosis factor receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002959
InterPro:IPR006052
InterPro:IPR006053

F

Seeded From UniProt

complete

protected

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002959
InterPro:IPR006052
InterPro:IPR006053

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002959
InterPro:IPR006052
InterPro:IPR006053

C

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

protected

involved_in

GO:0050890

cognition

PMID:22277195

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051966

regulation of synaptic transmission, glutamatergic

PMID:22277195

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1903978

regulation of microglial cell activation

PMID:22277195

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0150078

positive regulation of neuroinflammatory response

PMID:22277195
PMID:26753638

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

protected

involved_in

GO:0050768

negative regulation of neurogenesis

PMID:20018408

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

has_agent:(CL:0000129)

Seeded From UniProt

complete

protected

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:29702085

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:2000778

positive regulation of interleukin-6 secretion

PMID:29702085

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

  • regulates_o_occurs_in:(CL:2000043)
  • has_regulation_target:(UniProtKB:P05231)

Seeded From UniProt

complete

protected

involved_in

GO:0050729

positive regulation of inflammatory response

PMID:24966471

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0009651

response to salt stress

PMID:18355445

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:2000304

positive regulation of ceramide biosynthetic process

Reactome:R-HSA-5626978

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0071550

death-inducing signaling complex assembly

Reactome:R-HSA-5357786

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0033209

tumor necrosis factor-mediated signaling pathway

Reactome:R-HSA-75893
Reactome:R-HSA-5668541
PMID:24966471
PMID:24966471

ECO:0000304

author statement supported by traceable reference used in manual assertion




P

Seeded From UniProt

complete

protected

involved_in

GO:0019221

cytokine-mediated signaling pathway

Reactome:R-HSA-6785807
Reactome:R-HSA-6783783

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

protected

involved_in

GO:0010803

regulation of tumor necrosis factor-mediated signaling pathway

Reactome:R-HSA-5357905

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007249

I-kappaB kinase/NF-kappaB signaling

Reactome:R-HSA-5357956

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-8863101
Reactome:R-HSA-83660
Reactome:R-HSA-83656
Reactome:R-HSA-83582
Reactome:R-HSA-5693108
Reactome:R-HSA-5693055
Reactome:R-HSA-5668481
Reactome:R-HSA-5668467
Reactome:R-HSA-5668454
Reactome:R-HSA-5668417
Reactome:R-HSA-5668414
Reactome:R-HSA-5668404
Reactome:R-HSA-5634221
Reactome:R-HSA-5626988
Reactome:R-HSA-5626982
Reactome:R-HSA-5626981
Reactome:R-HSA-5626953
Reactome:R-HSA-5357928
Reactome:R-HSA-5357904
Reactome:R-HSA-5357860
Reactome:R-HSA-5357845
Reactome:R-HSA-5357780
Reactome:R-HSA-5357776
Reactome:R-HSA-5357757
Reactome:R-HSA-3371385

ECO:0000304

author statement supported by traceable reference used in manual assertion

























C

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

Reactome:R-HSA-8863101
Reactome:R-HSA-83656
Reactome:R-HSA-83582
Reactome:R-HSA-6789524
Reactome:R-HSA-6789325
Reactome:R-HSA-6784160
Reactome:R-HSA-5693108
Reactome:R-HSA-5693055
Reactome:R-HSA-5634221
Reactome:R-HSA-5626988
Reactome:R-HSA-5626982
Reactome:R-HSA-5626981
Reactome:R-HSA-5626953
Reactome:R-HSA-5357928
Reactome:R-HSA-5357904
Reactome:R-HSA-5357860
Reactome:R-HSA-5357845
Reactome:R-HSA-5357780
Reactome:R-HSA-5357776
Reactome:R-HSA-5357757
Reactome:R-HSA-3371385
Reactome:R-HSA-3371353
PMID:24966471

ECO:0000304

author statement supported by traceable reference used in manual assertion























C

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

protected

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

protected

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

protected

enables

GO:0005125

cytokine activity

PMID:24966471
PMID:24966471

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

part_of:(GO:0033209)

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

PMID:24966471

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

part_of:(CL:0000129)|part_of:(CL:0000127)|part_of:(CL:0000540)|part_of:(UBERON:0001017)

Seeded From UniProt

complete

protected

part_of

GO:0032991

protein-containing complex

PMID:24966471
PMID:24966471

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

  • part_of:(GO:0016020)
  • part_of:(CL:0000129)|part_of:(GO:0016020)
  • part_of:(CL:0000127)|part_of:(GO:0016020)
  • part_of:(CL:0000540)

Seeded From UniProt

complete




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