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HUMAN:TGFR2

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

protected

involved_in

GO:1990428

miRNA transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

  • transports_or_maintains_localization_of:(RNAcentral:URS00005C2A6D_9606)
  • occurs_in:(CL:0000192)|transports_or_maintains_localization_of(RNAcentral:URS0000527F89_9606)
  • occurs_in:(CL:0000192)

Seeded From UniProt

complete

protected

involved_in

GO:1905317

inferior endocardial cushion morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

NOT|involved_in

GO:1905316

superior endocardial cushion morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:2000563

positive regulation of CD4-positive, alpha-beta T cell proliferation

PMID:17164348

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0003274

endocardial cushion fusion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

occurs_in:(UBERON:0002087)

Seeded From UniProt

complete

protected

involved_in

GO:0003214

cardiac left ventricle morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0003186

tricuspid valve morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0003181

atrioventricular valve morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0003149

membranous septum morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0003148

outflow tract septum morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

NOT|involved_in

GO:1905315

cell proliferation involved in endocardial cushion morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:1905007

positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

  • occurs_in:(UBERON:0002087)
  • occurs_in:(UBERON:0008307)

Seeded From UniProt

complete

protected

involved_in

GO:0060412

ventricular septum morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

occurs_in:(UBERON:0002349)

Seeded From UniProt

complete

protected

involved_in

GO:0003151

outflow tract morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0001947

heart looping

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

occurs_in:(UBERON:0008307)

Seeded From UniProt

complete

protected

part_of

GO:0045121

membrane raft

PMID:25893292

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0010718

positive regulation of epithelial to mesenchymal transition

PMID:26459119

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:1000497)

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:25893292

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0043235

receptor complex

PMID:7852346

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:2000379

positive regulation of reactive oxygen species metabolic process

PMID:20160708

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0070723

response to cholesterol

PMID:17878231

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0060389

pathway-restricted SMAD protein phosphorylation

PMID:18453574

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0062009

secondary palate development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0051138

positive regulation of NK T cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

enables

GO:0050431

transforming growth factor beta binding

PMID:1333888

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P61812

F

Seeded From UniProt

complete

protected

enables

GO:0050431

transforming growth factor beta binding

PMID:1333888

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P10600

F

Seeded From UniProt

complete

protected

enables

GO:0050431

transforming growth factor beta binding

PMID:1333888

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P01137

F

Seeded From UniProt

complete

protected

enables

GO:0050431

transforming growth factor beta binding

PMID:1326540

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P01137

F

Seeded From UniProt

complete

protected

enables

GO:0050431

transforming growth factor beta binding

PMID:18243111

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0050431

transforming growth factor beta binding

PMID:18453574

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0050431

transforming growth factor beta binding

PMID:7852346

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0048701

embryonic cranial skeleton morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

enables

GO:0046332

SMAD binding

PMID:18453574

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0046332

SMAD binding

PMID:11157754

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0043235

receptor complex

PMID:8774881

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0043011

myeloid dendritic cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0042493

response to drug

PMID:17878231

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042127

regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0035162

embryonic hemopoiesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

enables

GO:0034713

type I transforming growth factor beta receptor binding

PMID:1333888

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P36897

F

Seeded From UniProt

complete

protected

involved_in

GO:0032147

activation of protein kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0018107

peptidyl-threonine phosphorylation

PMID:12015308

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:12015308

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

PMID:7852346

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0009897

external side of plasma membrane

PMID:18453574

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0007507

heart development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0007420

brain development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:1333888

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:18453574

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:1326540

ECO:0000305

curator inference used in manual assertion

GO:0050431

P

Seeded From UniProt

complete

protected

involved_in

GO:0006468

protein phosphorylation

PMID:12015308

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005901

caveola

PMID:17878231

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0005539

glycosaminoglycan binding

PMID:7852346

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

contributes_to

GO:0050431

transforming growth factor beta binding

PMID:7852346

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P61812

F

Seeded From UniProt

complete

protected

enables

GO:0005024

transforming growth factor beta-activated receptor activity

PMID:1333888

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0005024

transforming growth factor beta-activated receptor activity

PMID:18453574

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0005024

transforming growth factor beta-activated receptor activity

PMID:7852346

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0005024

transforming growth factor beta-activated receptor activity

PMID:1326540

ECO:0000305

curator inference used in manual assertion

GO:0050431

F

Seeded From UniProt

complete

protected

enables

GO:0004675

transmembrane receptor protein serine/threonine kinase activity

PMID:12015308

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0002666

positive regulation of T cell tolerance induction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0002663

positive regulation of B cell tolerance induction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0002651

positive regulation of tolerance induction to self antigen

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0002053

positive regulation of mesenchymal cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0001570

vasculogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0001569

branching involved in blood vessel morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62312

P

Seeded From UniProt

complete

protected

involved_in

GO:0006915

apoptotic process

PMID:17471240

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0046332

SMAD binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98728
MGI:MGI:98729
PANTHER:PTN000583675
RGD:621789
UniProtKB:O00238
UniProtKB:P36894
UniProtKB:P36896
UniProtKB:P36897
UniProtKB:P37023
UniProtKB:P37173
UniProtKB:Q04771

F

Seeded From UniProt

complete

protected

part_of

GO:0043235

receptor complex

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000583675
UniProtKB:P27037
UniProtKB:P36896
UniProtKB:P36897
UniProtKB:P37173
UniProtKB:Q13705

C

Seeded From UniProt

complete

protected

enables

GO:0034713

type I transforming growth factor beta receptor binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001147373
UniProtKB:P37173
UniProtKB:Q90999

F

Seeded From UniProt

complete

protected

enables

GO:0019838

growth factor binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102806
MGI:MGI:87911
MGI:MGI:87912
PANTHER:PTN000583675
RGD:71082
UniProtKB:P36896
UniProtKB:P36897
UniProtKB:Q13705
UniProtKB:Q8NER5

F

Seeded From UniProt

complete

protected

involved_in

GO:0007507

heart development

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98729
PANTHER:PTN000583682
UniProtKB:Q90999

P

Seeded From UniProt

complete

protected

involved_in

GO:0007389

pattern specification process

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1338938
MGI:MGI:87912
PANTHER:PTN000583675

P

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003716
MGI:MGI:1338946
MGI:MGI:87911
MGI:MGI:98728
MGI:MGI:98729
PANTHER:PTN000583675
RGD:3852
RGD:620200
RGD:69651
RGD:70964
UniProtKB:A0A0B4KG59
UniProtKB:P36897
UniProtKB:P37023
UniProtKB:P37173
UniProtKB:Q04771
UniProtKB:Q06900
UniProtKB:Q90ZK6

P

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87911
PANTHER:PTN000583675
RGD:69651
RGD:70964
UniProtKB:P36896
UniProtKB:P37023
UniProtKB:Q04771
UniProtKB:Q13873

C

Seeded From UniProt

complete

protected

enables

GO:0005026

transforming growth factor beta receptor activity, type II

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001147373
RGD:69651

F

Seeded From UniProt

complete

protected

enables

GO:0005024

transforming growth factor beta-activated receptor activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98728
MGI:MGI:98729
PANTHER:PTN000583675
UniProtKB:A0A0B4KG59
UniProtKB:P36897
UniProtKB:P37023
UniProtKB:P37173
ZFIN:ZDB-GENE-070618-1

F

Seeded From UniProt

complete

protected

involved_in

GO:0060044

negative regulation of cardiac muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0048661

positive regulation of smooth muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0048565

digestive tract development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0048545

response to steroid hormone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

part_of

GO:0045121

membrane raft

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

C

Seeded From UniProt

complete

protected

involved_in

GO:0043627

response to estrogen

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0043415

positive regulation of skeletal muscle tissue regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0042060

wound healing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

enables

GO:0031435

mitogen-activated protein kinase kinase kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

F

Seeded From UniProt

complete

protected

involved_in

GO:0031100

animal organ regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0030324

lung development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0014070

response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0010033

response to organic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

C

Seeded From UniProt

complete

protected

involved_in

GO:0009887

animal organ morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0009749

response to glucose

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0009612

response to mechanical stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0007584

response to nutrient

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0007566

embryo implantation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0007182

common-partner SMAD protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0006898

receptor-mediated endocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

part_of

GO:0005901

caveola

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

C

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

C

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

C

Seeded From UniProt

complete

protected

enables

GO:0005026

transforming growth factor beta receptor activity, type II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

F

Seeded From UniProt

complete

protected

involved_in

GO:0001666

response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:0001570

vasculogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P38438
ensembl:ENSRNOP00000035501

P

Seeded From UniProt

complete

protected

involved_in

GO:1990428

miRNA transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:1990086

lens fiber cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:1905317

inferior endocardial cushion morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:1905007

positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0070723

response to cholesterol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0062009

secondary palate development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0060463

lung lobe morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0060443

mammary gland morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0060440

trachea formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0060439

trachea morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0060434

bronchus morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0060433

bronchus development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0060425

lung morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0060412

ventricular septum morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0051216

cartilage development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0051138

positive regulation of NK T cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

enables

GO:0050431

transforming growth factor beta binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

F

Seeded From UniProt

complete

protected

involved_in

GO:0048701

embryonic cranial skeleton morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

enables

GO:0046332

SMAD binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

F

Seeded From UniProt

complete

protected

involved_in

GO:0045766

positive regulation of angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0043011

myeloid dendritic cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0042127

regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0035162

embryonic hemopoiesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0032147

activation of protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0030324

lung development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0010634

positive regulation of epithelial cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0010468

regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

part_of

GO:0009897

external side of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

C

Seeded From UniProt

complete

protected

involved_in

GO:0007507

heart development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0007420

brain development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0007369

gastrulation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0007224

smoothened signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0007219

Notch signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

enables

GO:0005024

transforming growth factor beta-activated receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

F

Seeded From UniProt

complete

protected

involved_in

GO:0003430

growth plate cartilage chondrocyte growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0003417

growth plate cartilage development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0003274

endocardial cushion fusion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0003214

cardiac left ventricle morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0003186

tricuspid valve morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0003181

atrioventricular valve morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0003151

outflow tract morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0003149

membranous septum morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0003148

outflow tract septum morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0002666

positive regulation of T cell tolerance induction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0002663

positive regulation of B cell tolerance induction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0002651

positive regulation of tolerance induction to self antigen

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0002088

lens development in camera-type eye

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0002053

positive regulation of mesenchymal cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0001947

heart looping

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0001701

in utero embryonic development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0001570

vasculogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

involved_in

GO:0001569

branching involved in blood vessel morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62312
ensembl:ENSMUSP00000062333

P

Seeded From UniProt

complete

protected

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008271

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017194

F

Seeded From UniProt

complete

protected

enables

GO:0004675

transmembrane receptor protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000333

F

Seeded From UniProt

complete

protected

enables

GO:0005026

transforming growth factor beta receptor activity, type II

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015013

F

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000333
InterPro:IPR000719
InterPro:IPR015013
InterPro:IPR017441

F

Seeded From UniProt

complete

protected

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008271
InterPro:IPR015013

P

Seeded From UniProt

complete

protected

involved_in

GO:0007178

transmembrane receptor protein serine/threonine kinase signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000333

P

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017194

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000333
InterPro:IPR015013

C

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017194

C

Seeded From UniProt

complete

protected

enables

GO:0038023

signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017194

F

Seeded From UniProt

complete

protected

part_of

GO:0043235

receptor complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017194

C

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015013
InterPro:IPR017194

F

Seeded From UniProt

complete

protected

part_of

GO:0043235

receptor complex

PMID:11157754

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:11157754

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

contributes_to

GO:0050431

transforming growth factor beta binding

PMID:11157754

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P61812

F

Seeded From UniProt

complete

protected

involved_in

GO:0060389

pathway-restricted SMAD protein phosphorylation

PMID:11157754

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0050431

transforming growth factor beta binding

PMID:11157754

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0046332

SMAD binding

PMID:11157754

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0034714

type III transforming growth factor beta receptor binding

PMID:11157754

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0034713

type I transforming growth factor beta receptor binding

PMID:11157754

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:11157754

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:7761852

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0001568

blood vessel development

PMID:10092230

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

Reactome:R-HSA-2173788
Reactome:R-HSA-173512
Reactome:R-HSA-173483

ECO:0000304

author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

protected

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

Reactome:R-HSA-2173791
Reactome:R-HSA-2173789

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

Reactome:R-NUL-2179313
Reactome:R-NUL-2179307
Reactome:R-NUL-2176431
Reactome:R-NUL-2176427
Reactome:R-NUL-2176396
Reactome:R-NUL-2176393
Reactome:R-NUL-2169043
Reactome:R-NUL-2169036
Reactome:R-NUL-2167890
Reactome:R-NUL-2167872
Reactome:R-NUL-2161165
Reactome:R-NUL-2161160
Reactome:R-NUL-2128982
Reactome:R-HSA-4332236
Reactome:R-HSA-4332235
Reactome:R-HSA-3713560
Reactome:R-HSA-3702186
Reactome:R-HSA-3702184
Reactome:R-HSA-3702153
Reactome:R-HSA-3656523
Reactome:R-HSA-3656517
Reactome:R-HSA-3656484
Reactome:R-HSA-3656382
Reactome:R-HSA-3645786
Reactome:R-HSA-3645780
Reactome:R-HSA-3645778
Reactome:R-HSA-3304394
Reactome:R-HSA-2169046
Reactome:R-HSA-2160935
Reactome:R-HSA-2160932
Reactome:R-HSA-2160931
Reactome:R-HSA-2128994
Reactome:R-HSA-173512
Reactome:R-HSA-173483
Reactome:R-HSA-170868
Reactome:R-HSA-170861
Reactome:R-HSA-170850
Reactome:R-HSA-170846
Reactome:R-HSA-170843
Reactome:R-HSA-170835

ECO:0000304

author statement supported by traceable reference used in manual assertion








































C

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

Reactome:R-HSA-3642203

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

protected

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

protected

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

protected

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

protected

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

protected

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

protected

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

protected

involved_in

GO:0040008

regulation of growth

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0341

P

Seeded From UniProt

complete

protected

part_of

GO:0045121

membrane raft

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0370

C

Seeded From UniProt

complete




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