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HUMAN:ESR2

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0010552

positive regulation of gene-specific transcription from RNA polymerase II promoter

PMID:21487105

ECO:0000314

P

Figure 3 details the effects of the introduction of the ER-beta gene into a cell culture already expressing KLF5. Figure 3A shows that the gene product of ER-beta dramatically increases expression of the FOXO1 gene, the expression of which was measured through a direct luciferase assay.

complete

protected

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR000324
InterPro:IPR001628
InterPro:IPR001723

F

Seeded From UniProt

complete

protected

enables

GO:0030284

estrogen receptor activity

PMID:19126643

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q00175

F

Seeded From UniProt

complete

protected

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:20074560

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:20074560

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0034056

estrogen response element binding

PMID:19126643

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:19126643

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0004879

nuclear receptor activity

PMID:19126643

ECO:0000314

direct assay evidence used in manual assertion

F

activated_by:(CHEBI:16469)

Seeded From UniProt

complete

protected

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

PMID:10681512

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0048019

receptor antagonist activity

PMID:9671811

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0034056

estrogen response element binding

PMID:15345745

ECO:0000314

direct assay evidence used in manual assertion

F

has_participant:(UniProtKB:P24387)

Seeded From UniProt

complete

protected

involved_in

GO:0030308

negative regulation of cell growth

PMID:11181953

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0019899

enzyme binding

PMID:12039952

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P55345

F

Seeded From UniProt

complete

protected

enables

GO:0005496

steroid binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62986

F

Seeded From UniProt

complete

protected

enables

GO:0004879

nuclear receptor activity

PMID:9671811

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:15345745

ECO:0000314

direct assay evidence used in manual assertion

F

has_participant:(UniProtKB:P24387)

Seeded From UniProt

complete

protected

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:15345745

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P24387)|has_regulation_target:(UniProtKB:P24388)

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

PMID:15024130

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:21951318

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q92731

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:21182203

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q92731

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:19022902

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q92731

F

Seeded From UniProt

complete

protected

involved_in

GO:2000272

negative regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048019

P

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001723
InterPro:IPR024178

F

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628

F

Seeded From UniProt

complete

protected

enables

GO:0003707

steroid hormone receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001723
InterPro:IPR024178

F

Seeded From UniProt

complete

protected

enables

GO:0005496

steroid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024178

F

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628
InterPro:IPR001723
InterPro:IPR024178

C

Seeded From UniProt

complete

protected

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628
InterPro:IPR001723
InterPro:IPR013088
InterPro:IPR024178

P

Seeded From UniProt

complete

protected

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628
InterPro:IPR013088
InterPro:IPR024178

F

Seeded From UniProt

complete

protected

enables

GO:0030284

estrogen receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028355

F

Seeded From UniProt

complete

protected

involved_in

GO:0030520

intracellular estrogen receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028355

P

Seeded From UniProt

complete

protected

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628

F

Seeded From UniProt

complete

protected

involved_in

GO:0071392

cellular response to estradiol stimulus

PMID:24033289

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:24033289

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0034056

estrogen response element binding

PMID:24033289

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0030520

intracellular estrogen receptor signaling pathway

PMID:24033289

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0030284

estrogen receptor activity

PMID:24033289

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0007267

cell-cell signaling

PMID:8769313

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007165

signal transduction

PMID:8769313
PMID:10749889

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

protected

enables

GO:0003713

transcription coactivator activity

PMID:8769313

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003707

steroid hormone receptor activity

PMID:10749889

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

PMID:8769313

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

PMID:9636657

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0030520

intracellular estrogen receptor signaling pathway

PMID:11181953

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0030284

estrogen receptor activity

PMID:11181953

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:11181953

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:11181953

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0005496

steroid binding

PMID:11181953

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0006367

transcription initiation from RNA polymerase II promoter

Reactome:R-HSA-383280

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-9038029
Reactome:R-HSA-8939204
Reactome:R-HSA-8939203
Reactome:R-HSA-8939201
Reactome:R-HSA-376419

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

protected

enables

GO:0008289

lipid binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0446

F

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

enables

GO:0005496

steroid binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0754

F

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete




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