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MOUSE:PARK7

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0051583

dopamine uptake

PMID:15799973

ECO:0000315

P

Figure 4: the loss of DJ-1 function in mice can lead to motor deficits as well as alterations in nigrostriatal dopaminergic function

complete

protected

involved_in

GO:0002866

positive regulation of acute inflammatory response to antigenic stimulus

PMID:26021615

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0033864

positive regulation of NAD(P)H oxidase activity

PMID:26021615

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0106046

guanine deglycation, glyoxal removal

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

involved_in

GO:0106045

guanine deglycation, methylglyoxal removal

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

involved_in

GO:0106044

guanine deglycation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

involved_in

GO:0006281

DNA repair

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

involved_in

GO:1903189

glyoxal metabolic process

PMID:22523093

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1903427

negative regulation of reactive oxygen species biosynthetic process

PMID:22611253

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030073

insulin secretion

PMID:22611253

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0042593

glucose homeostasis

PMID:22611253

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

NOT|involved_in

GO:0036530

protein deglycation, methylglyoxal removal

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

NOT|involved_in

GO:0009438

methylglyoxal metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

NOT|involved_in

GO:0006517

protein deglycosylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

involved_in

GO:0006517

protein deglycosylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

enables

GO:0045340

mercury ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

enables

GO:0005507

copper ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

involved_in

GO:0050787

detoxification of mercury ion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

involved_in

GO:0010273

detoxification of copper ion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

involved_in

GO:0010273

detoxification of copper ion

PMID:23792957

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050787

detoxification of mercury ion

PMID:23792957

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

PMID:14652021

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1903384

negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway

PMID:14652021

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050821

protein stabilization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

involved_in

GO:0050821

protein stabilization

PMID:19229105

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:17015834

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • has_regulation_target:(UniProtKB:Q64669)
  • has_regulation_target:(UniProtKB:O09172)

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:22492997

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P10639)

Seeded From UniProt

complete

protected

involved_in

GO:0051444

negative regulation of ubiquitin-protein transferase activity

PMID:24899725

ECO:0000305

curator inference used in manual assertion

GO:0031397

P

has_regulation_target:(UniProtKB:P40338)

Seeded From UniProt

complete

protected

involved_in

GO:0042177

negative regulation of protein catabolic process

PMID:24899725

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • has_regulation_target:(UniProtKB:Q61221)
  • part_of:(GO:0034599)

Seeded From UniProt

complete

protected

involved_in

GO:1903204

negative regulation of oxidative stress-induced neuron death

PMID:24899725

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1902958

positive regulation of mitochondrial electron transport, NADH to ubiquinone

PMID:19822128

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:22523093

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0036471)

Seeded From UniProt

complete

protected

involved_in

GO:0046295

glycolate biosynthetic process

PMID:22523093

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0031397

negative regulation of protein ubiquitination

PMID:24899725

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q61221)

Seeded From UniProt

complete

protected

involved_in

GO:0036471

cellular response to glyoxal

PMID:22523093

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

PMID:20969476

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:20969476

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:1903208

negative regulation of hydrogen peroxide-induced neuron death

PMID:24947010

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002609)

Seeded From UniProt

complete

protected

part_of

GO:0044297

cell body

PMID:24947010

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002609)

Seeded From UniProt

complete

protected

part_of

GO:0043005

neuron projection

PMID:24947010

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002609)

Seeded From UniProt

complete

protected

part_of

GO:0005758

mitochondrial intermembrane space

PMID:15944198

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0000955)

Seeded From UniProt

complete

protected

part_of

GO:0005759

mitochondrial matrix

PMID:15944198

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0000955)

Seeded From UniProt

complete

protected

involved_in

GO:0018323

enzyme active site formation via L-cysteine sulfinic acid

PMID:17766438

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

PMID:15944198

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002435)
  • part_of:(UBERON:0002038)
  • part_of:(UBERON:0000956)

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:15944198

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002435)
  • part_of:(UBERON:0002038)
  • part_of:(UBERON:0000956)

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21097510

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P13597)

Seeded From UniProt

complete

protected

involved_in

GO:2000277

positive regulation of oxidative phosphorylation uncoupler activity

PMID:21068725

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0070301

cellular response to hydrogen peroxide

PMID:15784737

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0060548

negative regulation of cell death

PMID:15784737

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050821

protein stabilization

PMID:17015834

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0050727

regulation of inflammatory response

PMID:19276172

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0043523

regulation of neuron apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

enables

GO:0042803

protein homodimerization activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

involved_in

GO:0034599

cellular response to oxidative stress

PMID:21068725

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032091

negative regulation of protein binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

enables

GO:0008233

peptidase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

involved_in

GO:0007005

mitochondrion organization

PMID:20186336

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

protected

enables

GO:0003729

mRNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

involved_in

GO:0106046

guanine deglycation, glyoxal removal

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000111103
UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

involved_in

GO:0036529

protein deglycation, glyoxal removal

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000111103
UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

enables

GO:0036524

protein deglycase activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13272
PANTHER:PTN000111103
UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13272
MGI:MGI:2135637
PANTHER:PTN000111103
PomBase:SPAC22E12.03c
RGD:621808
TAIR:locus:2086295
UniProtKB:C6KTB1
UniProtKB:Q99497

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2135637
PANTHER:PTN000111108
PomBase:SPAC22E12.03c
RGD:621808
TAIR:locus:2086295
UniProtKB:Q99497
WB:WBGene00015184

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:2001268

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:2000825

positive regulation of androgen receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:2000679

positive regulation of transcription regulatory region DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:2000157

negative regulation of ubiquitin-specific protease activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

enables

GO:1990381

ubiquitin-specific protease binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1905516

positive regulation of fertilization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1905259

negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1904782

negative regulation of NMDA glutamate receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903428

positive regulation of reactive oxygen species biosynthetic process

PMID:22555455

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903384

negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903377

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903208

negative regulation of hydrogen peroxide-induced neuron death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903206

negative regulation of hydrogen peroxide-induced cell death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903202

negative regulation of oxidative stress-induced cell death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903200

positive regulation of L-dopa decarboxylase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903197

positive regulation of L-dopa biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903189

glyoxal metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903181

positive regulation of dopamine biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903178

positive regulation of tyrosine 3-monooxygenase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903168

positive regulation of pyrroline-5-carboxylate reductase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

enables

GO:1903136

cuprous ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

enables

GO:1903135

cupric ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903122

negative regulation of TRAIL-activated apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1903094

negative regulation of protein K48-linked deubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1902958

positive regulation of mitochondrial electron transport, NADH to ubiquinone

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1902177

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

PMID:22555455

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1901984

negative regulation of protein acetylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1901671

positive regulation of superoxide dismutase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1901215

negative regulation of neuron death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1901215

negative regulation of neuron death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:1900182

positive regulation of protein localization to nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0106046

guanine deglycation, glyoxal removal

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0106045

guanine deglycation, methylglyoxal removal

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0106044

guanine deglycation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

enables

GO:0097110

scaffold protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0090073

positive regulation of protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

enables

GO:0070491

repressing transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0070301

cellular response to hydrogen peroxide

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

part_of

GO:0061827

sperm head

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060765

regulation of androgen receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060548

negative regulation of cell death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060081

membrane hyperpolarization

PMID:16624565

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3579140

P

Seeded From UniProt

complete

protected

enables

GO:0051920

peroxiredoxin activity

PMID:17766438

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3514165

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051899

membrane depolarization

PMID:16624565

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3579140

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051583

dopamine uptake involved in synaptic transmission

PMID:15721235

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3579140

P

occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051444

negative regulation of ubiquitin-protein transferase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0050821

protein stabilization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0050787

detoxification of mercury ion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

enables

GO:0050681

androgen receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0046826

negative regulation of protein export from nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0046295

glycolate biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

enables

GO:0045340

mercury ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

part_of

GO:0045121

membrane raft

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

C

Seeded From UniProt

complete

protected

enables

GO:0044390

ubiquitin-like protein conjugating enzyme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

enables

GO:0044388

small protein activating enzyme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043523

regulation of neuron apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

enables

GO:0042803

protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0042743

hydrogen peroxide metabolic process

PMID:17766438

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3514165

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0042743

hydrogen peroxide metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0042542

response to hydrogen peroxide

PMID:15784737

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3576227

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0042542

response to hydrogen peroxide

PMID:15784737

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0036531

glutathione deglycation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0036529

protein deglycation, glyoxal removal

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0036528

peptidyl-lysine deglycation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0036527

peptidyl-arginine deglycation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0036526

peptidyl-cysteine deglycation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

enables

GO:0036524

protein deglycase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

enables

GO:0036478

L-dopa decarboxylase activator activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0036471

cellular response to glyoxal

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

enables

GO:0036470

tyrosine 3-monooxygenase activator activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0034614

cellular response to reactive oxygen species

PMID:16624565

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3579140

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0034599

cellular response to oxidative stress

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0033234

negative regulation of protein sumoylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0033138

positive regulation of peptidyl-serine phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032757

positive regulation of interleukin-8 production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032091

negative regulation of protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0031397

negative regulation of protein ubiquitination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

part_of

GO:0030424

axon

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

C

Seeded From UniProt

complete

protected

enables

GO:0019955

cytokine binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

enables

GO:0019900

kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

enables

GO:0019899

enzyme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0019249

lactate biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

enables

GO:0016684

oxidoreductase activity, acting on peroxide as acceptor

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

protected

enables

GO:0016532

superoxide dismutase copper chaperone activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0010629

negative regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0010273

detoxification of copper ion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0008344

adult locomotory behavior

PMID:15799973

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3586448

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0008344

adult locomotory behavior

PMID:15721235

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3579140

P

Seeded From UniProt

complete

protected

enables

GO:0008233

peptidase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

enables

GO:0008134

transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006469

negative regulation of protein kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006281

DNA repair

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

PMID:22555455

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

C

Seeded From UniProt

complete

protected

part_of

GO:0005783

endoplasmic reticulum

PMID:22555455

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

colocalizes_with

GO:0005747

mitochondrial respiratory chain complex I

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

PMID:18614015

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

PMID:22555455

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

PMID:17766438

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:22555455

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:621808

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

protected

enables

GO:0005507

copper ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

enables

GO:0005102

signaling receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

enables

GO:0003729

mRNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

enables

GO:0003713

transcription coactivator activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0001963

synaptic transmission, dopaminergic

PMID:15799973

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3586448

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0001933

negative regulation of protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

protected

part_of

GO:0000785

chromatin

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q99497

C

Seeded From UniProt

complete

protected

part_of

GO:0098793

presynapse

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0051583

C

Seeded From UniProt

complete

protected

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0051920

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

protected

part_of

GO:0005747

mitochondrial respiratory chain complex I

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

protected

enables

GO:0005507

copper ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

enables

GO:0005102

signaling receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

enables

GO:0003729

mRNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

enables

GO:0003713

transcription coactivator activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

involved_in

GO:0001933

negative regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

part_of

GO:0000785

chromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

protected

involved_in

GO:2001268

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:2000825

positive regulation of androgen receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:2000679

positive regulation of transcription regulatory region DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:2000157

negative regulation of ubiquitin-specific protease activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

enables

GO:1990381

ubiquitin-specific protease binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

involved_in

GO:1905259

negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1903384

negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1903377

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1903208

negative regulation of hydrogen peroxide-induced neuron death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1903206

negative regulation of hydrogen peroxide-induced cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1903202

negative regulation of oxidative stress-induced cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1903200

positive regulation of L-dopa decarboxylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1903197

positive regulation of L-dopa biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1903189

glyoxal metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1903181

positive regulation of dopamine biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1903178

positive regulation of tyrosine 3-monooxygenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1903168

positive regulation of pyrroline-5-carboxylate reductase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

enables

GO:1903136

cuprous ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

enables

GO:1903135

cupric ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

involved_in

GO:1903122

negative regulation of TRAIL-activated apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1903094

negative regulation of protein K48-linked deubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1902958

positive regulation of mitochondrial electron transport, NADH to ubiquinone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1901984

negative regulation of protein acetylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1901671

positive regulation of superoxide dismutase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1901215

negative regulation of neuron death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:1900182

positive regulation of protein localization to nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0106046

guanine deglycation, glyoxal removal

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0106044

guanine deglycation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

enables

GO:0097110

scaffold protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

involved_in

GO:0090073

positive regulation of protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

enables

GO:0070491

repressing transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

involved_in

GO:0070301

cellular response to hydrogen peroxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0060765

regulation of androgen receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0060548

negative regulation of cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0051444

negative regulation of ubiquitin-protein transferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0050821

protein stabilization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0050787

detoxification of mercury ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

enables

GO:0050681

androgen receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

protected

involved_in

GO:0046826

negative regulation of protein export from nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0046295

glycolate biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

enables

GO:0045340

mercury ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

enables

GO:0044390

ubiquitin-like protein conjugating enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

enables

GO:0044388

small protein activating enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

involved_in

GO:0043524

negative regulation of neuron apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0043523

regulation of neuron apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

involved_in

GO:0042743

hydrogen peroxide metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0036531

glutathione deglycation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0036529

protein deglycation, glyoxal removal

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0036528

peptidyl-lysine deglycation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0036527

peptidyl-arginine deglycation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0036526

peptidyl-cysteine deglycation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

enables

GO:0036524

protein deglycase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

enables

GO:0036478

L-dopa decarboxylase activator activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

involved_in

GO:0036471

cellular response to glyoxal

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

enables

GO:0036470

tyrosine 3-monooxygenase activator activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

involved_in

GO:0034599

cellular response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0033234

negative regulation of protein sumoylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0032757

positive regulation of interleukin-8 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0032091

negative regulation of protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0031397

negative regulation of protein ubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

enables

GO:0019955

cytokine binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

enables

GO:0019900

kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

enables

GO:0019899

enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

involved_in

GO:0019249

lactate biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

enables

GO:0016684

oxidoreductase activity, acting on peroxide as acceptor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

part_of

GO:0016605

PML body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

protected

enables

GO:0016532

superoxide dismutase copper chaperone activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

involved_in

GO:0010629

negative regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0010273

detoxification of copper ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

enables

GO:0008233

peptidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

F

Seeded From UniProt

complete

protected

involved_in

GO:0006469

negative regulation of protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

involved_in

GO:0006281

DNA repair

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99497
ensembl:ENSP00000340278

P

Seeded From UniProt

complete

protected

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:V9HWC2
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:V9HWC2
ensembl:ENSP00000340278

C

Seeded From UniProt

complete

protected

enables

GO:0003723

RNA binding

PMID:11223268

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

protected

involved_in

GO:0006914

autophagy

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0072

P

Seeded From UniProt

complete

protected

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

protected

involved_in

GO:0006954

inflammatory response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

protected

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

protected

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

protected

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

protected

involved_in

GO:0007338

single fertilization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0278

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

protected

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

protected

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

protected

part_of

GO:0045121

membrane raft

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0370

C

Seeded From UniProt

complete




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