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HUMAN:CALCR

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

protected

part_of

GO:0150058

amylin receptor complex 3

PMID:22500019

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0150057

amylin receptor complex 2

PMID:22500019

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0001540

amyloid-beta binding

PMID:22500019

ECO:0000305

curator inference used in manual assertion

GO:1904645

F

Seeded From UniProt

complete

protected

involved_in

GO:1904645

response to amyloid-beta

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896

P

Seeded From UniProt

complete

protected

involved_in

GO:0038041

cross-receptor inhibition within G protein-coupled receptor heterodimer

PMID:14722252

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O60896

P

Seeded From UniProt

complete

protected

enables

GO:0097643

amylin receptor activity

PMID:14722252

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O60894

F

Seeded From UniProt

complete

protected

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:14722252

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60895,UniProtKB:P35318

P

Seeded From UniProt

complete

protected

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60895,UniProtKB:P12969:PRO_0000004122

P

Seeded From UniProt

complete

protected

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P35318

P

Seeded From UniProt

complete

protected

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P12969:PRO_0000004122

P

Seeded From UniProt

complete

protected

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P10997:PRO_0000004106

P

Seeded From UniProt

complete

protected

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P06881

P

Seeded From UniProt

complete

protected

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

ComplexPortal:CPX-2173

P

Seeded From UniProt

complete

protected

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60895,UniProtKB:P12969:PRO_0000004122

P

Seeded From UniProt

complete

protected

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60895,UniProtKB:P35318

P

Seeded From UniProt

complete

protected

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P06881

P

Seeded From UniProt

complete

protected

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P35318

P

Seeded From UniProt

complete

protected

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P12969:PRO_0000004122

P

Seeded From UniProt

complete

protected

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P10997:PRO_0000004106

P

Seeded From UniProt

complete

protected

involved_in

GO:0010942

positive regulation of cell death

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

regulates_expression_of:(ENSEMBL:ENSG00000170345)

Seeded From UniProt

complete

protected

involved_in

GO:0010942

positive regulation of cell death

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

ComplexPortal:CPX-1134,UniProtKB:O60896

P

Seeded From UniProt

complete

protected

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

ComplexPortal:CPX-1134,UniProtKB:O60896

P

Seeded From UniProt

complete

protected

involved_in

GO:0097647

amylin receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

Seeded From UniProt

complete

protected

contributes_to

GO:0097643

amylin receptor activity

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60894,UniProtKB:P06881
UniProtKB:O60894,UniProtKB:P10997:PRO_0000004106
UniProtKB:O60894,UniProtKB:P12969:PRO_0000004122
UniProtKB:O60894,UniProtKB:P35318
UniProtKB:O60895,UniProtKB:P12969:PRO_0000004122
UniProtKB:O60895,UniProtKB:P35318
UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

F

Seeded From UniProt

complete

protected

involved_in

GO:0010628

positive regulation of gene expression

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

regulates_expression_of:(ENSEMBL:ENSG00000170345)

Seeded From UniProt

complete

protected

involved_in

GO:0051897

positive regulation of protein kinase B signaling

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

ComplexPortal:CPX-1134,UniProtKB:O60896

P

Seeded From UniProt

complete

protected

involved_in

GO:0051897

positive regulation of protein kinase B signaling

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

Seeded From UniProt

complete

protected

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P05067:PRO_0000000092

P

Seeded From UniProt

complete

protected

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

Seeded From UniProt

complete

protected

involved_in

GO:0010739

positive regulation of protein kinase A signaling

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

has_regulation_target:(UniProtKB:P13861)

Seeded From UniProt

complete

protected

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

has_regulation_target:(UniProtKB:P13861)

Seeded From UniProt

complete

protected

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

ComplexPortal:CPX-1134,UniProtKB:O60896

P

has_regulation_target:(UniProtKB:P13861)

Seeded From UniProt

complete

protected

involved_in

GO:1905665

positive regulation of calcium ion import across plasma membrane

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

ComplexPortal:CPX-1134,UniProtKB:O60896

P

Seeded From UniProt

complete

protected

involved_in

GO:1905665

positive regulation of calcium ion import across plasma membrane

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

Seeded From UniProt

complete

protected

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P12969:PRO_0000004122

P

Seeded From UniProt

complete

protected

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

ComplexPortal:CPX-1134,UniProtKB:O60896

P

Seeded From UniProt

complete

protected

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:22500019

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:O60896,UniProtKB:P10997:PRO_0000004106

P

Seeded From UniProt

complete

protected

part_of

GO:0150056

amylin receptor complex 1

PMID:22500019

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0051384

response to glucocorticoid

PMID:11250927

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:15563840

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0032841

calcitonin binding

PMID:15563840

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P01263

F

Seeded From UniProt

complete

protected

enables

GO:0032841

calcitonin binding

PMID:8078488

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

NOT|enables

GO:0032841

calcitonin binding

PMID:15563840

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:14722252

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

NOT|involved_in

GO:0007190

activation of adenylate cyclase activity

PMID:15563840

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:7619207

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:1331173

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

PMID:7588285

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0001635

calcitonin gene-related peptide receptor activity

PMID:14722252

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O60894

F

Seeded From UniProt

complete

protected

contributes_to

GO:0097643

amylin receptor activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001381030
UniProtKB:P30988

F

Seeded From UniProt

complete

protected

part_of

GO:0030424

axon

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001381030
RGD:621001

C

Seeded From UniProt

complete

protected

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101950
PANTHER:PTN001381030
UniProtKB:P30988

P

Seeded From UniProt

complete

protected

enables

GO:0004948

calcitonin receptor activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101950
PANTHER:PTN001381030
RGD:621001
UniProtKB:P25117
UniProtKB:P30988

F

Seeded From UniProt

complete

protected

enables

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017981

F

Seeded From UniProt

complete

protected

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR001879
InterPro:IPR017983
InterPro:IPR036445

F

Seeded From UniProt

complete

protected

enables

GO:0004948

calcitonin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001688
InterPro:IPR003287

F

Seeded From UniProt

complete

protected

involved_in

GO:0007166

cell surface receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017981

P

Seeded From UniProt

complete

protected

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR003287
InterPro:IPR017983

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001688
InterPro:IPR001879
InterPro:IPR003287
InterPro:IPR036445

C

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000832
InterPro:IPR017981

C

Seeded From UniProt

complete

protected

involved_in

GO:0045762

positive regulation of adenylate cyclase activity

PMID:7588285

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045762

positive regulation of adenylate cyclase activity

PMID:7769107

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0032841

calcitonin binding

PMID:7588285

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q91157

F

Seeded From UniProt

complete

protected

enables

GO:0032841

calcitonin binding

PMID:7769107

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

NOT|involved_in

GO:0007202

activation of phospholipase C activity

PMID:4961748

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

PMID:7619207

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0004948

calcitonin receptor activity

PMID:7588285

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004948

P

Seeded From UniProt

complete

protected

involved_in

GO:0045762

positive regulation of adenylate cyclase activity

PMID:7769107

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0032841

calcitonin binding

PMID:8078488

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P01258

F

Seeded From UniProt

complete

protected

enables

GO:0032841

calcitonin binding

PMID:7769107

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:8078488

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005623

cell

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0007204

C

Seeded From UniProt

complete

protected

involved_in

GO:0045762

positive regulation of adenylate cyclase activity

PMID:7588285

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0032841

calcitonin binding

PMID:7588285

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q91157

F

Seeded From UniProt

complete

protected

enables

GO:0004948

calcitonin receptor activity

PMID:7588285

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004948

P

Seeded From UniProt

complete

protected

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-744887
Reactome:R-HSA-744886
Reactome:R-HSA-420265
Reactome:R-HSA-419843
Reactome:R-HSA-379044

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

protected

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

protected

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

protected

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete




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