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HUMAN:TFE2

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

protected

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR011598

F

Seeded From UniProt

complete

protected

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q61286

F

Seeded From UniProt

complete

protected

part_of

GO:0090575

RNA polymerase II transcription factor complex

PMID:10545951

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0001227

DNA-binding transcription repressor activity, RNA polymerase II-specific

PMID:14576336

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

protected

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:14576336

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:14576336

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

contributes_to

GO:0070888

E-box binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P15806-1

F

Seeded From UniProt

complete

protected

enables

GO:0070644

vitamin D response element binding

PMID:17426122

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0046982

protein heterodimerization activity

PMID:10545951

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13562

F

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P15806-1

P

Seeded From UniProt

complete

protected

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P15806-1

P

Seeded From UniProt

complete

protected

enables

GO:0043425

bHLH transcription factor binding

PMID:21828274

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99081

F

occurs_in:(CL:0002322)

Seeded From UniProt

complete

protected

enables

GO:0043425

bHLH transcription factor binding

PMID:10545951

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13562

F

Seeded From UniProt

complete

protected

enables

GO:0035326

enhancer binding

PMID:21828274

ECO:0000305

curator inference used in manual assertion

GO:0000790

F

  • part_of:(CL:0002322)
  • has_input:(ENSEMBL:ENSG00000243709)

Seeded From UniProt

complete

protected

enables

GO:0008134

transcription factor binding

PMID:21828274

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O75593

F

occurs_in:(CL:0002322)|occurs_in:(UBERON:0000925)

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:21828274

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002322)|part_of:(UBERON:0000925)

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21828274

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0000925)

Seeded From UniProt

complete

protected

part_of

GO:0000790

nuclear chromatin

PMID:21828274

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002322)

Seeded From UniProt

complete

protected

contributes_to

GO:0070888

E-box binding

PMID:10775504

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0070888

E-box binding

PMID:7933101

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0070491

repressing transcription factor binding

PMID:12493738

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O43680

F

Seeded From UniProt

complete

protected

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

PMID:14752053

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0046982

protein heterodimerization activity

PMID:10775504

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0046982

protein heterodimerization activity

PMID:14752053

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0046982

protein heterodimerization activity

PMID:2105528

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:19362560

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:2105528

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045666

positive regulation of neuron differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P15806

P

Seeded From UniProt

complete

protected

enables

GO:0043425

bHLH transcription factor binding

PMID:10775504

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q7RTU7

F

Seeded From UniProt

complete

protected

enables

GO:0042803

protein homodimerization activity

PMID:14752053

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0042803

protein homodimerization activity

PMID:10958665

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0031435

mitogen-activated protein kinase kinase kinase binding

PMID:19801649

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q02779

F

Seeded From UniProt

complete

protected

involved_in

GO:0030183

B cell differentiation

PMID:12435739

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:2493990

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006351

transcription, DNA-templated

PMID:10775504

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005667

transcription factor complex

PMID:10775504

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:10775504

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:12493738

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:2493990

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0003713

transcription coactivator activity

PMID:14752053

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

PMID:2105528

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

PMID:2493990

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

PMID:10958665

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

PMID:2105528

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0002326

B cell lineage commitment

PMID:12435739

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0046982

protein heterodimerization activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0267821
MGI:MGI:101877
MGI:MGI:98506
MGI:MGI:98510
PANTHER:PTN000927455
UniProtKB:P15923
UniProtKB:Q70IK3
WB:WBGene00001949

F

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0267821
MGI:MGI:98506
MGI:MGI:98510
PANTHER:PTN000927455
RGD:3829
RGD:69271
UniProtKB:P15923
UniProtKB:Q99081
WB:WBGene00001949

P

Seeded From UniProt

complete

protected

involved_in

GO:0045666

positive regulation of neuron differentiation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101877
MGI:MGI:98506
MGI:MGI:98510
PANTHER:PTN000927455

P

Seeded From UniProt

complete

protected

enables

GO:0043425

bHLH transcription factor binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000927455
RGD:620914
RGD:69271
UniProtKB:P15923
UniProtKB:Q99081
WB:WBGene00001949

F

Seeded From UniProt

complete

protected

enables

GO:0042803

protein homodimerization activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0267821
MGI:MGI:98510
PANTHER:PTN000927455
UniProtKB:P15923
WB:WBGene00001949

F

Seeded From UniProt

complete

protected

involved_in

GO:0033152

immunoglobulin V(D)J recombination

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98510
PANTHER:PTN000209822
UniProtKB:P15923

P

Seeded From UniProt

complete

protected

part_of

GO:0005667

transcription factor complex

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0267821
MGI:MGI:101877
MGI:MGI:98506
MGI:MGI:98510
PANTHER:PTN000927455
RGD:620914
UniProtKB:P15923
UniProtKB:Q70IK3

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0267821
MGI:MGI:98506
MGI:MGI:98510
PANTHER:PTN000927455
RGD:3829
UniProtKB:P15884
UniProtKB:P15923
UniProtKB:Q99081
WB:WBGene00001949

C

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0267821
MGI:MGI:98510
PANTHER:PTN000927455
UniProtKB:P15884
UniProtKB:P15923
UniProtKB:Q99081

F

Seeded From UniProt

complete

protected

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98506
MGI:MGI:98510
PANTHER:PTN000927455
UniProtKB:P15884
UniProtKB:P15923
UniProtKB:Q99081

F

Seeded From UniProt

complete

protected

enables

GO:0046982

protein heterodimerization activity

PMID:19323994

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:16428437

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0033152

immunoglobulin V(D)J recombination

PMID:16428437

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0016607

nuclear speck

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0046983

protein dimerization activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011598
InterPro:IPR036638

F

Seeded From UniProt

complete

protected

part_of

GO:0090575

RNA polymerase II transcription factor complex

PMID:11802795

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:16043483

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:15509787

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

contributes_to

GO:0044212

transcription regulatory region DNA binding

PMID:11802795

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0043425

bHLH transcription factor binding

PMID:10749989

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q15672

F

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:10749989

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

PMID:15509787

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

PMID:11802795

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

contributes_to

GO:0043565

sequence-specific DNA binding

PMID:15044608

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0008134

transcription factor binding

PMID:15044608

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q6QHK4

F

Seeded From UniProt

complete

protected

enables

GO:0008134

transcription factor binding

PMID:2503252

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P10085

F

Seeded From UniProt

complete

protected

part_of

GO:0005667

transcription factor complex

PMID:15044608

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005667

transcription factor complex

PMID:2503252

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

contributes_to

GO:0003677

DNA binding

PMID:2503252

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0090575

RNA polymerase II transcription factor complex

PMID:11802795

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:16043483

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

contributes_to

GO:0044212

transcription regulatory region DNA binding

PMID:11802795

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

PMID:11802795

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:2000045

regulation of G1/S transition of mitotic cell cycle

PMID:11509675

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:11509675

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:12435739

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045787

positive regulation of cell cycle

PMID:11509675

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0032991

protein-containing complex

PMID:12435739

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0042803

protein homodimerization activity

PMID:8759016

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0030890

positive regulation of B cell proliferation

PMID:11509675

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:12435739

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:12435739

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

PMID:11509675

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

PMID:12435739

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

PMID:8759016

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

involved_in

GO:0002326

B cell lineage commitment

PMID:15030778

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1902036

regulation of hematopoietic stem cell differentiation

Reactome:R-HSA-8939236

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0051149

positive regulation of muscle cell differentiation

Reactome:R-HSA-375170

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8956586
Reactome:R-HSA-8956568
Reactome:R-HSA-448963

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

protected

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

involved_in

GO:0007399

nervous system development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete




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