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ZFIN:wnt11

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Contents

Species (Taxon ID) Danio rerio (zebrafish) (taxon:7955)
Gene Name(s) wnt11
Protein Name(s) wingless-type MMTV integration site family, member 11,
External Links
ZFIN ZDB-GENE-990603-12

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000132

establishment of mitotic spindle orientation

ZFIN:ZDB-PUB-040719-4
PMID:15254551[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-050826-1

P

From ZFIN

GO:0001664

G-protein coupled receptor binding

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR12027_AN0

F

From ZFIN

GO:0001702

gastrulation with mouth forming second

ZFIN:ZDB-PUB-050607-6
PMID:15928205[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1408

P

From ZFIN

GO:0001702

gastrulation with mouth forming second

ZFIN:ZDB-PUB-051005-6
PMID:16198297[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1037

P

From ZFIN

GO:0001702

gastrulation with mouth forming second

ZFIN:ZDB-PUB-970602-19
PMID:9142986[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1037

P

From ZFIN

GO:0001839

neural plate morphogenesis

ZFIN:ZDB-PUB-060602-1
PMID:15996547[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1037

P

From ZFIN

GO:0001947

heart looping

ZFIN:ZDB-PUB-101004-8
PMID:20843857[6]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-070316-4
ZFIN:ZDB-MRPHLNO-060209-7

P

From ZFIN

GO:0005099

Ras GTPase activator activity

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

F

From ZFIN

GO:0005102

receptor binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR005817

F

From ZFIN

GO:0005576

extracellular region

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0964

C

From ZFIN

GO:0005576

extracellular region

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR005817

C

From ZFIN

GO:0005578

proteinaceous extracellular matrix

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0272

C

From ZFIN

GO:0005578

proteinaceous extracellular matrix

ZFIN:ZDB-PUB-120306-2

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0111

C

From ZFIN

GO:0005578

proteinaceous extracellular matrix

ZFIN:ZDB-PUB-120306-4

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0111

C

From ZFIN

GO:0005615

extracellular space

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR12027_AN0

C

From ZFIN

GO:0005737

cytoplasm

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

C

From ZFIN

GO:0005886

plasma membrane

ZFIN:ZDB-PUB-051005-6
PMID:16198297[3]

IMP: Inferred from Mutant Phenotype

C

From ZFIN

GO:0005886

plasma membrane

ZFIN:ZDB-PUB-061227-6
PMID:17130287[7]

IDA: Inferred from Direct Assay

C

From ZFIN

GO:0006468

protein phosphorylation

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

P

From ZFIN

GO:0007275

multicellular organismal development

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

From ZFIN

GO:0007275

multicellular organismal development

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR005817

P

From ZFIN

GO:0007417

central nervous system development

ZFIN:ZDB-PUB-970602-19
PMID:9142986[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1037

P

From ZFIN

GO:0007492

endoderm development

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR12027_AN384

P

From ZFIN

GO:0007507

heart development

ZFIN:ZDB-PUB-050106-5
PMID:15630025[8]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-050318-1
ZFIN:ZDB-MRPHLNO-050318-3
ZFIN:ZDB-MRPHLNO-050318-4

P

From ZFIN

GO:0007507

heart development

ZFIN:ZDB-PUB-050106-5
PMID:15630025[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050318-3

P

From ZFIN

GO:0008078

mesodermal cell migration

ZFIN:ZDB-PUB-080826-15
PMID:18701549[9]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-070911-1
ZFIN:ZDB-MRPHLNO-070911-3

P

From ZFIN

GO:0008078

mesodermal cell migration

ZFIN:ZDB-PUB-080826-15
PMID:18701549[9]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-070911-1
ZFIN:ZDB-MRPHLNO-081222-1

P

From ZFIN

GO:0008078

mesodermal cell migration

ZFIN:ZDB-PUB-080826-15
PMID:18701549[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070911-1

P

From ZFIN

GO:0008104

protein localization

ZFIN:ZDB-PUB-061227-6
PMID:17130287[7]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-990415-223

P

From ZFIN

GO:0009798

axis specification

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR12027_AN0

P

From ZFIN

GO:0009952

anterior/posterior pattern specification

ZFIN:ZDB-PUB-110330-1

PANTHER:PTHR12027_AN0

P

From ZFIN

GO:0016055

Wnt receptor signaling pathway

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0879

P

From ZFIN

GO:0016055

Wnt receptor signaling pathway

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR005817

P

From ZFIN

GO:0016337

cell-cell adhesion

ZFIN:ZDB-PUB-051005-6
PMID:16198297[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1037

P

From ZFIN

GO:0016337

cell-cell adhesion

ZFIN:ZDB-PUB-061227-6
PMID:17130287[7]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-990415-223

P

From ZFIN

GO:0016337

cell-cell adhesion

ZFIN:ZDB-PUB-061227-6
PMID:17130287[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070316-4

P

From ZFIN

GO:0016477

cell migration

ZFIN:ZDB-PUB-970602-19
PMID:9142986[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1037

P

From ZFIN

GO:0030100

regulation of endocytosis

ZFIN:ZDB-PUB-051005-6
PMID:16198297[3]

IMP: Inferred from Mutant Phenotype

P

From ZFIN

GO:0030295

protein kinase activator activity

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

F

From ZFIN

GO:0030308

negative regulation of cell growth

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

P

From ZFIN

GO:0030335

positive regulation of cell migration

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

P

From ZFIN

GO:0030336

negative regulation of cell migration

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

P

From ZFIN

GO:0032320

positive regulation of Ras GTPase activity

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

P

From ZFIN

GO:0034394

protein localization at cell surface

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

P

From ZFIN

GO:0035567

non-canonical Wnt receptor signaling pathway

ZFIN:ZDB-PUB-060602-1
PMID:15996547[5]

IMP: Inferred from Mutant Phenotype

P

From ZFIN

GO:0042074

cell migration involved in gastrulation

ZFIN:ZDB-PUB-050106-5
PMID:15630025[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050318-3

P

From ZFIN

GO:0042074

cell migration involved in gastrulation

ZFIN:ZDB-PUB-050718-9
PMID:16019189[10]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-041217-10

P

From ZFIN

GO:0042074

cell migration involved in gastrulation

ZFIN:ZDB-PUB-051005-6
PMID:16198297[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1037

P

From ZFIN

GO:0042074

cell migration involved in gastrulation

ZFIN:ZDB-PUB-060602-1
PMID:15996547[5]

IMP: Inferred from Mutant Phenotype

P

From ZFIN

GO:0042074

cell migration involved in gastrulation

ZFIN:ZDB-PUB-061020-33
PMID:17032765[11]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-041217-10
ZFIN:ZDB-MRPHLNO-041217-11

P

From ZFIN

GO:0042074

cell migration involved in gastrulation

ZFIN:ZDB-PUB-080826-15
PMID:18701549[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070911-1

P

From ZFIN

GO:0043010

camera-type eye development

ZFIN:ZDB-PUB-970210-16
PMID:9007240[12]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1037

P

From ZFIN

GO:0043010

camera-type eye development

ZFIN:ZDB-PUB-970210-16
PMID:9007240[12]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1408

P

From ZFIN

GO:0043066

negative regulation of apoptotic process

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

P

From ZFIN

GO:0044212

transcription regulatory region DNA binding

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

F

From ZFIN

GO:0045859

regulation of protein kinase activity

ZFIN:ZDB-PUB-070711-34
PMID:17611617[13]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-041217-10

P

From ZFIN

GO:0045892

negative regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

P

From ZFIN

GO:0045893

positive regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

P

From ZFIN

GO:0048048

embryonic eye morphogenesis

ZFIN:ZDB-PUB-060602-1
PMID:15996547[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1037

P

From ZFIN

GO:0048048

embryonic eye morphogenesis

ZFIN:ZDB-PUB-970602-19
PMID:9142986[4]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-980202-1495

P

From ZFIN

GO:0048048

embryonic eye morphogenesis

ZFIN:ZDB-PUB-970602-19
PMID:9142986[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1037

P

From ZFIN

GO:0051496

positive regulation of stress fiber assembly

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

P

From ZFIN

GO:0060021

palate development

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

P

From ZFIN

GO:0060026

convergent extension

ZFIN:ZDB-PUB-071009-3
PMID:17906624[14]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-080222-4
ZFIN:ZDB-MRPHLNO-060126-1

P

From ZFIN

GO:0060026

convergent extension

ZFIN:ZDB-PUB-071009-3
PMID:17906624[14]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-080222-4
ZFIN:ZDB-MRPHLNO-060208-1

P

From ZFIN

GO:0060026

convergent extension

ZFIN:ZDB-PUB-071009-3
PMID:17906624[14]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-080222-4
ZFIN:ZDB-MRPHLNO-060208-2

P

From ZFIN

GO:0060027

convergent extension involved in gastrulation

ZFIN:ZDB-PUB-010904-1
PMID:11702784[15]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-100715-12

P

From ZFIN

GO:0060027

convergent extension involved in gastrulation

ZFIN:ZDB-PUB-020624-2
PMID:12062050[16]

IMP: Inferred from Mutant Phenotype

P

From ZFIN

GO:0060027

convergent extension involved in gastrulation

ZFIN:ZDB-PUB-030408-5
PMID:12676324[17]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070911-1

P

From ZFIN

GO:0060027

convergent extension involved in gastrulation

ZFIN:ZDB-PUB-070304-1
PMID:15815683[18]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-041217-10
ZFIN:ZDB-MRPHLNO-050128-3
ZFIN:ZDB-MRPHLNO-070304-3

P

From ZFIN

GO:0060027

convergent extension involved in gastrulation

ZFIN:ZDB-PUB-070304-1
PMID:15815683[18]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-041217-10

P

From ZFIN

GO:0060027

convergent extension involved in gastrulation

ZFIN:ZDB-PUB-080616-12
PMID:18538138[19]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-050318-3
ZFIN:ZDB-MRPHLNO-080912-1

P

From ZFIN

GO:0060027

convergent extension involved in gastrulation

ZFIN:ZDB-PUB-080826-15
PMID:18701549[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070911-1

P

From ZFIN

GO:0060027

convergent extension involved in gastrulation

ZFIN:ZDB-PUB-081031-7
PMID:18971206[20]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-041217-10
ZFIN:ZDB-MRPHLNO-090312-2

P

From ZFIN

GO:0060027

convergent extension involved in gastrulation

ZFIN:ZDB-PUB-100302-20
PMID:20188722[21]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-041217-10
ZFIN:ZDB-MRPHLNO-100614-1

P

From ZFIN

GO:0060027

convergent extension involved in gastrulation

ZFIN:ZDB-PUB-100302-20
PMID:20188722[21]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-041217-10
ZFIN:ZDB-MRPHLNO-100714-3
ZFIN:ZDB-MRPHLNO-100714-4

P

From ZFIN

GO:0060031

mediolateral intercalation

ZFIN:ZDB-PUB-000518-1
PMID:10811221[22]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1037

P

From ZFIN

GO:0060031

mediolateral intercalation

ZFIN:ZDB-PUB-000518-1
PMID:10811221[22]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1408

P

From ZFIN

GO:0060898

eye field cell fate commitment involved in camera-type eye formation

ZFIN:ZDB-PUB-060602-1
PMID:15996547[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1037

P

From ZFIN

GO:0061101

neuroendocrine cell differentiation

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

P

From ZFIN

GO:0070121

Kupffer's vesicle development

ZFIN:ZDB-PUB-101004-8
PMID:20843857[6]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-070316-4
ZFIN:ZDB-MRPHLNO-060209-7

P

From ZFIN

GO:0090037

positive regulation of protein kinase C signaling cascade

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

P

From ZFIN

GO:0090090

negative regulation of canonical Wnt receptor signaling pathway

ZFIN:ZDB-PUB-060602-1
PMID:15996547[5]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-980202-1037
ZFIN:ZDB-MRPHLNO-060705-6

P

From ZFIN

GO:0090090

negative regulation of canonical Wnt receptor signaling pathway

ZFIN:ZDB-PUB-110105-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O96014

P

From ZFIN

NOT

GO:0031016

pancreas development

ZFIN:ZDB-PUB-010205-4
PMID:11161572[23]

IMP: Inferred from Mutant Phenotype

P

From ZFIN


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Gong Y et al. (2004) Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation. Nature 430: 689-93 PubMed GONUTS page
  2. Lin F et al. (2005) Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements. J Cell Biol 169: 777-87 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Ulrich F et al. (2005) Wnt11 functions in gastrulation by controlling cell cohesion through Rab5c and E-cadherin. Dev Cell 9: 555-64 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Heisenberg CP & Nüsslein-Volhard C (1997) The function of silberblick in the positioning of the eye anlage in the zebrafish embryo. Dev Biol 184: 85-94 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 Cavodeassi F et al. (2005) Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway. Neuron 47: 43-56 PubMed GONUTS page
  6. 6.0 6.1 Oteiza P et al. (2010) Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ. Development 137: 3459-68 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Witzel S et al. (2006) Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane. J Cell Biol 175: 791-802 PubMed GONUTS page
  8. 8.0 8.1 8.2 Matsui T et al. (2005) Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes Dev 19: 164-75 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 Kai M et al. (2008) Sphingosine-1-phosphate receptors regulate individual cell behaviours underlying the directed migration of prechordal plate progenitor cells during zebrafish gastrulation. Development 135: 3043-51 PubMed GONUTS page
  10. Zhu S et al. (2006) RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho kinase and Diaphanous: use of zebrafish as an in vivo model for GTPase signaling. Cell Signal 18: 359-72 PubMed GONUTS page
  11. Moeller H et al. (2006) Diversin regulates heart formation and gastrulation movements in development. Proc Natl Acad Sci U S A 103: 15900-5 PubMed GONUTS page
  12. 12.0 12.1 Heisenberg CP et al. (1996) Genes involved in forebrain development in the zebrafish, Danio rerio. Development 123: 191-203 PubMed GONUTS page
  13. Lemeer S et al. (2007) Protein-tyrosine kinase activity profiling in knock down zebrafish embryos. PLoS One 2: e581 PubMed GONUTS page
  14. 14.0 14.1 14.2 Gerdes JM et al. (2007) Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet 39: 1350-60 PubMed GONUTS page
  15. Topczewski J et al. (2001) The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension. Dev Cell 1: 251-64 PubMed GONUTS page
  16. Marlow F et al. (2002) Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements. Curr Biol 12: 876-84 PubMed GONUTS page
  17. Kilian B et al. (2003) The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech Dev 120: 467-76 PubMed GONUTS page
  18. 18.0 18.1 Jopling C & den Hertog J (2005) Fyn/Yes and non-canonical Wnt signalling converge on RhoA in vertebrate gastrulation cell movements. EMBO Rep 6: 426-31 PubMed GONUTS page
  19. Yao S et al. (2008) Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation. FEBS Lett 582: 2325-32 PubMed GONUTS page
  20. Ferrante MI et al. (2009) Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene. Hum Mol Genet 18: 289-303 PubMed GONUTS page
  21. 21.0 21.1 van Eekelen M et al. (2010) RPTPalpha and PTPepsilon signaling via Fyn/Yes and RhoA is essential for zebrafish convergence and extension cell movements during gastrulation. Dev Biol 340: 626-39 PubMed GONUTS page
  22. 22.0 22.1 Heisenberg CP et al. (2000) Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature 405: 76-81 PubMed GONUTS page
  23. Biemar F et al. (2001) Pancreas development in zebrafish: early dispersed appearance of endocrine hormone expressing cells and their convergence to form the definitive islet. Dev Biol 230: 189-203 PubMed GONUTS page
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