ZFIN:vegfaa

From GONUTS

Jump to: navigation, search

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001525	angiogenesis	ZFIN:ZDB-PUB-011002-6 PMID:11578859^[1]	IDA: Inferred from Direct Assay		P	From ZFIN
	GO:0001525	angiogenesis	ZFIN:ZDB-PUB-011002-6 PMID:11578859^[1]	IMP: Inferred from Mutant Phenotype		P	From ZFIN
	GO:0001525	angiogenesis	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0037	P	From ZFIN
	GO:0001525	angiogenesis	ZFIN:ZDB-PUB-060419-9 PMID:16617120^[2]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-050513-12 ZFIN:ZDB-MRPHLNO-051212-2 ZFIN:ZDB-MRPHLNO-051212-3	P	From ZFIN
	GO:0001525	angiogenesis	ZFIN:ZDB-PUB-060419-9 PMID:16617120^[2]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-050513-12	P	From ZFIN
	GO:0001525	angiogenesis	ZFIN:ZDB-PUB-060616-30 PMID:16753140^[3]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-050513-12	P	From ZFIN
	GO:0001525	angiogenesis	ZFIN:ZDB-PUB-080801-13 PMID:18664627^[4]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-050513-12	P	From ZFIN
	GO:0001525	angiogenesis	ZFIN:ZDB-PUB-100126-14 PMID:20096681^[5]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-051128-8	P	From ZFIN
	GO:0001568	blood vessel development	ZFIN:ZDB-PUB-060921-14 PMID:16968815^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-051128-8	P	From ZFIN
	GO:0001569	patterning of blood vessels	ZFIN:ZDB-PUB-001220-6 PMID:11119306^[7]	IMP: Inferred from Mutant Phenotype		P	From ZFIN
	GO:0001569	patterning of blood vessels	ZFIN:ZDB-PUB-090629-14 PMID:19542015^[8]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-050513-12 ZFIN:ZDB-MRPHLNO-110610-1	P	From ZFIN
	GO:0001569	patterning of blood vessels	ZFIN:ZDB-PUB-090629-14 PMID:19542015^[8]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-050513-12	P	From ZFIN
	GO:0001570	vasculogenesis	ZFIN:ZDB-PUB-011002-6 PMID:11578859^[1]	IDA: Inferred from Direct Assay		P	From ZFIN
	GO:0001570	vasculogenesis	ZFIN:ZDB-PUB-011002-6 PMID:11578859^[1]	IMP: Inferred from Mutant Phenotype		P	From ZFIN
	GO:0001570	vasculogenesis	ZFIN:ZDB-PUB-020820-6 PMID:12110173^[9]	IMP: Inferred from Mutant Phenotype		P	From ZFIN
	GO:0001570	vasculogenesis	ZFIN:ZDB-PUB-050711-7 PMID:15998812^[10]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-050513-12	P	From ZFIN
	GO:0001570	vasculogenesis	ZFIN:ZDB-PUB-050823-8 PMID:16110501^[11]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-050513-12	P	From ZFIN
	GO:0001944	vasculature development	ZFIN:ZDB-PUB-020807-23 PMID:12142468^[12]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-050513-12 ZFIN:ZDB-MRPHLNO-050906-3	P	From ZFIN
	GO:0001944	vasculature development	ZFIN:ZDB-PUB-020807-23 PMID:12142468^[12]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-050513-12	P	From ZFIN
	GO:0002040	sprouting angiogenesis	ZFIN:ZDB-PUB-020306-5 PMID:11861480^[13]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-050513-12	P	From ZFIN
	GO:0002040	sprouting angiogenesis	ZFIN:ZDB-PUB-060323-16 PMID:16537812^[14]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-050513-12 ZFIN:ZDB-MRPHLNO-060802-1	P	From ZFIN
	GO:0002040	sprouting angiogenesis	ZFIN:ZDB-PUB-060323-16 PMID:16537812^[14]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-060802-1	P	From ZFIN
	GO:0002040	sprouting angiogenesis	ZFIN:ZDB-PUB-090629-14 PMID:19542015^[8]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-050513-12 ZFIN:ZDB-MRPHLNO-110610-1	P	From ZFIN
	GO:0002040	sprouting angiogenesis	ZFIN:ZDB-PUB-091023-30 PMID:19815777^[15]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-051212-1	P	From ZFIN
	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ZFIN:ZDB-PUB-060323-16 PMID:16537812^[14]	IDA: Inferred from Direct Assay		P	From ZFIN
	GO:0005515	protein binding	ZFIN:ZDB-PUB-040609-10 PMID:15183302^[16]	IPI: Inferred from Physical Interaction	ZFIN:ZDB-GENE-040611-1	F	From ZFIN
	GO:0005515	protein binding	ZFIN:ZDB-PUB-070820-9 PMID:17698971^[17]	IPI: Inferred from Physical Interaction	UniProtKB:Q5GIT4	F	From ZFIN
	GO:0005515	protein binding	ZFIN:ZDB-PUB-070820-9 PMID:17698971^[17]	IPI: Inferred from Physical Interaction	UniProtKB:Q8AXB3	F	From ZFIN
	GO:0005576	extracellular region	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From ZFIN
	GO:0005576	extracellular region	ZFIN:ZDB-PUB-070820-9 PMID:17698971^[17]	IDA: Inferred from Direct Assay		C	From ZFIN
	GO:0005622	intracellular	ZFIN:ZDB-PUB-060323-16 PMID:16537812^[14]	IDA: Inferred from Direct Assay		C	From ZFIN
	GO:0007202	activation of phospholipase C activity	ZFIN:ZDB-PUB-060323-16 PMID:16537812^[14]	IDA: Inferred from Direct Assay		P	From ZFIN
	GO:0007275	multicellular organismal development	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From ZFIN
	GO:0008016	regulation of heart contraction	ZFIN:ZDB-PUB-050711-7 PMID:15998812^[10]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-050513-12	P	From ZFIN
	GO:0008045	motor axon guidance	ZFIN:ZDB-PUB-050823-8 PMID:16110501^[11]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-050513-12 ZFIN:ZDB-MRPHLNO-050906-3	P	From ZFIN
	GO:0008083	growth factor activity	ZFIN:ZDB-PUB-011002-6 PMID:11578859^[1]	IMP: Inferred from Mutant Phenotype		F	From ZFIN
	GO:0008083	growth factor activity	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0339	F	From ZFIN
	GO:0008083	growth factor activity	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR000072	F	From ZFIN
	GO:0016020	membrane	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR000072	C	From ZFIN
	GO:0016310	phosphorylation	ZFIN:ZDB-PUB-070820-9 PMID:17698971^[17]	IDA: Inferred from Direct Assay		P	From ZFIN
	GO:0030097	hemopoiesis	ZFIN:ZDB-PUB-011002-6 PMID:11578859^[1]	IDA: Inferred from Direct Assay		P	From ZFIN
	GO:0030097	hemopoiesis	ZFIN:ZDB-PUB-011002-6 PMID:11578859^[1]	IMP: Inferred from Mutant Phenotype		P	From ZFIN
	GO:0030154	cell differentiation	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0221	P	From ZFIN
	GO:0030878	thyroid gland development	ZFIN:ZDB-PUB-060921-14 PMID:16968815^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-051128-8	P	From ZFIN
	GO:0035477	regulation of angioblast cell migration involved in selective angioblast sprouting	ZFIN:ZDB-PUB-091023-30 PMID:19815777^[15]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-051212-1	P	From ZFIN
	GO:0035479	angioblast cell migration from lateral mesoderm to midline	ZFIN:ZDB-PUB-020306-5 PMID:11861480^[13]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-050513-12	P	From ZFIN
	GO:0043491	protein kinase B signaling cascade	ZFIN:ZDB-PUB-060323-16 PMID:16537812^[14]	IDA: Inferred from Direct Assay		P	From ZFIN
	GO:0048010	vascular endothelial growth factor receptor signaling pathway	ZFIN:ZDB-PUB-020820-6 PMID:12110173^[9]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-980202-1526	P	From ZFIN
	GO:0048793	pronephros development	ZFIN:ZDB-PUB-060616-30 PMID:16753140^[3]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-050513-12	P	From ZFIN
	GO:0048844	artery morphogenesis	ZFIN:ZDB-PUB-091023-30 PMID:19815777^[15]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-051212-1	P	From ZFIN
	GO:0051781	positive regulation of cell division	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0497	P	From ZFIN
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Liang D et al. (2001) The role of vascular endothelial growth factor (VEGF) in vasculogenesis, angiogenesis, and hematopoiesis in zebrafish development. Mech Dev 108: 29-43 PubMed GONUTS page
↑ ^2.0 ^2.1 Covassin LD et al. (2006) Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish. Proc Natl Acad Sci U S A 103: 6554-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Liu YW & Guo L (2006) Endothelium is required for the promotion of interrenal morphogenetic movement during early zebrafish development. Dev Biol 297: 44-58 PubMed GONUTS page
↑ Kawamura H et al. (2008) Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood 112: 3638-49 PubMed GONUTS page
↑ Christie TL et al. (2010) Syk and Zap-70 function redundantly to promote angioblast migration. Dev Biol 340: 22-9 PubMed GONUTS page
↑ ^6.0 ^6.1 Alt B et al. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development 133: 3797-804 PubMed GONUTS page
↑ Nasevicius A et al. (2000) Distinct requirements for zebrafish angiogenesis revealed by a VEGF-A morphant. Yeast 17: 294-301 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Hooper AT et al. (2009) Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis. Circ Res 105: 201-8 PubMed GONUTS page
↑ ^9.0 ^9.1 Lawson ND et al. (2002) sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell 3: 127-36 PubMed GONUTS page
↑ ^10.0 ^10.1 Rottbauer W et al. (2005) VEGF-PLCgamma1 pathway controls cardiac contractility in the embryonic heart. Genes Dev 19: 1624-34 PubMed GONUTS page
↑ ^11.0 ^11.1 Feldner J et al. (2005) Neuropilin-1a is involved in trunk motor axon outgrowth in embryonic zebrafish. Dev Dyn 234: 535-49 PubMed GONUTS page
↑ ^12.0 ^12.1 Lee P et al. (2002) Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish. Proc Natl Acad Sci U S A 99: 10470-5 PubMed GONUTS page
↑ ^13.0 ^13.1 Childs S et al. (2002) Patterning of angiogenesis in the zebrafish embryo. Development 129: 973-82 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Leung T et al. (2006) Zebrafish G protein gamma2 is required for VEGF signaling during angiogenesis. Blood 108: 160-6 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Herbert SP et al. (2009) Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science 326: 294-8 PubMed GONUTS page
↑ Bovenkamp DE et al. (2004) Expression and mapping of duplicate neuropilin-1 and neuropilin-2 genes in developing zebrafish. Gene Expr Patterns 4: 361-70 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Bahary N et al. (2007) Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish. Blood 110: 3627-36 PubMed GONUTS page

[PMID:11578859-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Liang D et al. (2001) The role of vascular endothelial growth factor (VEGF) in vasculogenesis, angiogenesis, and hematopoiesis in zebrafish development. Mech Dev 108: 29-43 PubMed GONUTS page

[PMID:16617120-1] 2.0 ^2.1 Covassin LD et al. (2006) Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish. Proc Natl Acad Sci U S A 103: 6554-9 PubMed GONUTS page

[PMID:16753140-2] 3.0 ^3.1 Liu YW & Guo L (2006) Endothelium is required for the promotion of interrenal morphogenetic movement during early zebrafish development. Dev Biol 297: 44-58 PubMed GONUTS page

[PMID:18664627-3] Kawamura H et al. (2008) Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood 112: 3638-49 PubMed GONUTS page

[PMID:20096681-4] Christie TL et al. (2010) Syk and Zap-70 function redundantly to promote angioblast migration. Dev Biol 340: 22-9 PubMed GONUTS page

[PMID:16968815-5] 6.0 ^6.1 Alt B et al. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development 133: 3797-804 PubMed GONUTS page

[PMID:11119306-6] Nasevicius A et al. (2000) Distinct requirements for zebrafish angiogenesis revealed by a VEGF-A morphant. Yeast 17: 294-301 PubMed GONUTS page

[PMID:19542015-7] 8.0 ^8.1 ^8.2 Hooper AT et al. (2009) Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis. Circ Res 105: 201-8 PubMed GONUTS page

[PMID:12110173-8] 9.0 ^9.1 Lawson ND et al. (2002) sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell 3: 127-36 PubMed GONUTS page

[PMID:15998812-9] 10.0 ^10.1 Rottbauer W et al. (2005) VEGF-PLCgamma1 pathway controls cardiac contractility in the embryonic heart. Genes Dev 19: 1624-34 PubMed GONUTS page

[PMID:16110501-10] 11.0 ^11.1 Feldner J et al. (2005) Neuropilin-1a is involved in trunk motor axon outgrowth in embryonic zebrafish. Dev Dyn 234: 535-49 PubMed GONUTS page

[PMID:12142468-11] 12.0 ^12.1 Lee P et al. (2002) Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish. Proc Natl Acad Sci U S A 99: 10470-5 PubMed GONUTS page

[PMID:11861480-12] 13.0 ^13.1 Childs S et al. (2002) Patterning of angiogenesis in the zebrafish embryo. Development 129: 973-82 PubMed GONUTS page

[PMID:16537812-13] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Leung T et al. (2006) Zebrafish G protein gamma2 is required for VEGF signaling during angiogenesis. Blood 108: 160-6 PubMed GONUTS page

[PMID:19815777-14] 15.0 ^15.1 ^15.2 Herbert SP et al. (2009) Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science 326: 294-8 PubMed GONUTS page

[PMID:15183302-15] Bovenkamp DE et al. (2004) Expression and mapping of duplicate neuropilin-1 and neuropilin-2 genes in developing zebrafish. Gene Expr Patterns 4: 361-70 PubMed GONUTS page

[PMID:17698971-16] 17.0 ^17.1 ^17.2 ^17.3 Bahary N et al. (2007) Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish. Blood 110: 3627-36 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

Species (Taxon ID)	Danio rerio (zebrafish) (taxon:7955)
Gene Name(s)	vegfaa
Protein Name(s)	vascular endothelial growth factor Aa,
External Links
ZFIN	ZDB-GENE-990415-273

ZFIN:vegfaa

Contents

Annotations

Notes

References

a

b

c

e

g

h

i

m

p

p cont.

r

s

t

v

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox