ZFIN:tp53

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000077	DNA damage checkpoint	ZFIN:ZDB-PUB-050106-6 PMID:15630097^[1]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050428-1	P	From ZFIN
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN0	P	From ZFIN
	GO:0000785	chromatin	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN0	C	From ZFIN
	GO:0002039	p53 binding	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN0	F	From ZFIN
	GO:0003677	DNA binding	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0238	F	From ZFIN
	GO:0003677	DNA binding	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	F	From ZFIN
	GO:0003677	DNA binding	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	F	From ZFIN
	GO:0003682	chromatin binding	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN0	F	From ZFIN
	GO:0003684	damaged DNA binding	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN0	F	From ZFIN
	GO:0003690	double-stranded DNA binding	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN0	F	From ZFIN
	GO:0003700	sequence-specific DNA binding transcription factor activity	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	F	From ZFIN
	GO:0003700	sequence-specific DNA binding transcription factor activity	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR008967	F	From ZFIN
	GO:0003700	sequence-specific DNA binding transcription factor activity	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	F	From ZFIN
	GO:0003700	sequence-specific DNA binding transcription factor activity	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN0	F	From ZFIN
	GO:0005515	protein binding	ZFIN:ZDB-PUB-041216-3 PMID:15590746^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q07998	F	From ZFIN
	GO:0005515	protein binding	ZFIN:ZDB-PUB-041216-3 PMID:15590746^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q6W4T8	F	From ZFIN
	GO:0005515	protein binding	ZFIN:ZDB-PUB-041216-3 PMID:15590746^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q90467	F	From ZFIN
	GO:0005622	intracellular	ZFIN:ZDB-PUB-050106-6 PMID:15630097^[1]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050428-1	C	From ZFIN
	GO:0005622	intracellular	ZFIN:ZDB-PUB-050602-6 PMID:15914672^[3]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-050725-1 ZFIN:ZDB-MRPHLNO-070126-7	C	From ZFIN
	GO:0005622	intracellular	ZFIN:ZDB-PUB-080602-16 PMID:18510930^[4]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050428-1	C	From ZFIN
	GO:0005634	nucleus	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0539	C	From ZFIN
	GO:0005634	nucleus	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	C	From ZFIN
	GO:0005634	nucleus	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	C	From ZFIN
	GO:0005634	nucleus	ZFIN:ZDB-PUB-120306-2	IEA: Inferred from Electronic Annotation	UniProtKB-SubCell:SL-0191	C	From ZFIN
	GO:0005634	nucleus	ZFIN:ZDB-PUB-120306-4	IEA: Inferred from Electronic Annotation	UniProtKB-SubCell:SL-0191	C	From ZFIN
	GO:0005657	replication fork	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN4	C	From ZFIN
	GO:0005667	transcription factor complex	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN0	C	From ZFIN
	GO:0005737	cytoplasm	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0963	C	From ZFIN
	GO:0005737	cytoplasm	ZFIN:ZDB-PUB-120306-2	IEA: Inferred from Electronic Annotation	UniProtKB-SubCell:SL-0086	C	From ZFIN
	GO:0005737	cytoplasm	ZFIN:ZDB-PUB-120306-4	IEA: Inferred from Electronic Annotation	UniProtKB-SubCell:SL-0086	C	From ZFIN
	GO:0005739	mitochondrion	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN4	C	From ZFIN
	GO:0005829	cytosol	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN0	C	From ZFIN
	GO:0006351	transcription, DNA-dependent	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From ZFIN
	GO:0006355	regulation of transcription, DNA-dependent	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0805	P	From ZFIN
	GO:0006355	regulation of transcription, DNA-dependent	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	P	From ZFIN
	GO:0006355	regulation of transcription, DNA-dependent	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR008967	P	From ZFIN
	GO:0006355	regulation of transcription, DNA-dependent	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR012346	P	From ZFIN
	GO:0006915	apoptotic process	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0053	P	From ZFIN
	GO:0006915	apoptotic process	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR002117	P	From ZFIN
	GO:0006915	apoptotic process	ZFIN:ZDB-PUB-110110-36 PMID:21209837^[5]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-100415-8 ZFIN:ZDB-MRPHLNO-070126-7	P	From ZFIN
	GO:0006917	induction of apoptosis	ZFIN:ZDB-PUB-041108-3 PMID:15529176^[6]	IMP: Inferred from Mutant Phenotype		P	From ZFIN
	GO:0006917	induction of apoptosis	ZFIN:ZDB-PUB-080422-7 PMID:18418056^[7]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-070126-7	P	From ZFIN
	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ZFIN:ZDB-PUB-050106-6 PMID:15630097^[1]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050428-1	P	From ZFIN
	GO:0007049	cell cycle	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0131	P	From ZFIN
	GO:0009411	response to UV	ZFIN:ZDB-PUB-041108-3 PMID:15529176^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-050107-3	P	From ZFIN
	GO:0010165	response to X-ray	ZFIN:ZDB-PUB-080422-7 PMID:18418056^[7]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-070126-7	P	From ZFIN
	GO:0010332	response to gamma radiation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN0	P	From ZFIN
	GO:0016525	negative regulation of angiogenesis	ZFIN:ZDB-PUB-111011-36 PMID:21949834^[8]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-111020-9 ZFIN:ZDB-MRPHLNO-070126-7	P	From ZFIN
	GO:0031065	positive regulation of histone deacetylation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN4	P	From ZFIN
	GO:0031571	mitotic cell cycle G1/S transition DNA damage checkpoint	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN0	P	From ZFIN
	GO:0034644	cellular response to UV	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN0	P	From ZFIN
	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	ZFIN:ZDB-PUB-050602-6 PMID:15914672^[3]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-050725-1 ZFIN:ZDB-MRPHLNO-070126-7	P	From ZFIN
	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	ZFIN:ZDB-PUB-080602-16 PMID:18510930^[4]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050428-1	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-031217-3 PMID:14667412^[9]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENE-040116-5	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-050106-6 PMID:15630097^[1]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050428-1	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-050106-6 PMID:15630097^[1]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050428-4	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-050818-6 PMID:16096653^[10]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-980202-1249 ZFIN:ZDB-MRPHLNO-050107-3	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-050818-6 PMID:16096653^[10]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-980202-1249 ZFIN:ZDB-MRPHLNO-070126-7	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-050818-6 PMID:16096653^[10]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-980202-1250 ZFIN:ZDB-MRPHLNO-050107-3	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-050818-6 PMID:16096653^[10]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-980202-1250 ZFIN:ZDB-MRPHLNO-070126-7	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-061108-9 PMID:17081288^[11]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-070109-1 ZFIN:ZDB-MRPHLNO-070126-7	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-070614-15 PMID:17530925^[12]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-051207-1 ZFIN:ZDB-MRPHLNO-070126-7	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-070614-15 PMID:17530925^[12]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-070126-7 ZFIN:ZDB-MRPHLNO-070405-1	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-070614-15 PMID:17530925^[12]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-070126-7 ZFIN:ZDB-MRPHLNO-070516-3	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-070614-15 PMID:17530925^[12]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-070126-7 ZFIN:ZDB-MRPHLNO-070719-2	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-070614-15 PMID:17530925^[12]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-070126-7 ZFIN:ZDB-MRPHLNO-070726-2	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-070614-15 PMID:17530925^[12]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-070126-7 ZFIN:ZDB-MRPHLNO-070727-3	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-080610-2 PMID:18514183^[13]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-070126-7	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-090731-2 PMID:19631206^[14]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-100112-12 ZFIN:ZDB-MRPHLNO-070126-7	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-100119-13 PMID:20075382^[15]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-100429-2	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-100119-13 PMID:20075382^[15]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-100429-3	P	From ZFIN
	GO:0043065	positive regulation of apoptotic process	ZFIN:ZDB-PUB-100119-13 PMID:20075382^[15]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-100429-7	P	From ZFIN
	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ZFIN:ZDB-PUB-060816-5 PMID:16888646^[16]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-070126-7	P	From ZFIN
	GO:0043525	positive regulation of neuron apoptotic process	ZFIN:ZDB-PUB-060210-19 PMID:16464238^[17]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-060331-1 ZFIN:ZDB-MRPHLNO-070126-7	P	From ZFIN
	GO:0043565	sequence-specific DNA binding	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11447_AN0	F	From ZFIN
	GO:0044212	transcription regulatory region DNA binding	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR011615	F	From ZFIN
	GO:0045786	negative regulation of cell cycle	ZFIN:ZDB-PUB-051207-21 PMID:16322560^[18]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-020426-45	P	From ZFIN
	GO:0045787	positive regulation of cell cycle	ZFIN:ZDB-PUB-100119-13 PMID:20075382^[15]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-100429-2	P	From ZFIN
	GO:0045787	positive regulation of cell cycle	ZFIN:ZDB-PUB-100119-13 PMID:20075382^[15]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-100429-7	P	From ZFIN
	GO:0045893	positive regulation of transcription, DNA-dependent	ZFIN:ZDB-PUB-020513-5 PMID:12015968^[19]	IDA: Inferred from Direct Assay		P	From ZFIN
	GO:0045893	positive regulation of transcription, DNA-dependent	ZFIN:ZDB-PUB-100119-13 PMID:20075382^[15]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-100429-2	P	From ZFIN
	GO:0045893	positive regulation of transcription, DNA-dependent	ZFIN:ZDB-PUB-100119-13 PMID:20075382^[15]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-100429-7	P	From ZFIN
	GO:0046872	metal ion binding	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0479	F	From ZFIN
	GO:0051262	protein tetramerization	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR010991	P	From ZFIN
	GO:0051597	response to methylmercury	ZFIN:ZDB-PUB-050701-14 PMID:15984772^[20]	IDA: Inferred from Direct Assay		P	From ZFIN
	GO:0051782	negative regulation of cell division	ZFIN:ZDB-PUB-091215-28 PMID:19954345^[21]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-100429-13	P	From ZFIN
	GO:0051782	negative regulation of cell division	ZFIN:ZDB-PUB-091215-28 PMID:19954345^[21]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-100429-15	P	From ZFIN
	GO:0071456	cellular response to hypoxia	ZFIN:ZDB-PUB-110803-20 PMID:21792176^[22]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-100414-1	P	From ZFIN
	GO:0071456	cellular response to hypoxia	ZFIN:ZDB-PUB-110803-20 PMID:21792176^[22]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-070719-1	P	From ZFIN
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Berghmans S et al. (2005) tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A 102: 407-12 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Ninkovic J et al. (2005) Inhibition of neurogenesis at the zebrafish midbrain-hindbrain boundary by the combined and dose-dependent activity of a new hairy/E(spl) gene pair. Development 132: 75-88 PubMed GONUTS page
↑ ^3.0 ^3.1 Bladen CL et al. (2005) DNA damage response and Ku80 function in the vertebrate embryo. Nucleic Acids Res 33: 3002-10 PubMed GONUTS page
↑ ^4.0 ^4.1 Sidi S et al. (2008) Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 133: 864-77 PubMed GONUTS page
↑ Danilova N et al. (2010) p53 upregulation is a frequent response to deficiency of cell-essential genes. PLoS One 5: e15938 PubMed GONUTS page
↑ ^6.0 ^6.1 Nowak M et al. (2005) Perp is required for tissue-specific cell survival during zebrafish development. Cell Death Differ 12: 52-64 PubMed GONUTS page
↑ ^7.0 ^7.1 Davidson W et al. (2008) Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos. Cell Cycle 7: 1224-30 PubMed GONUTS page
↑ Mouillesseaux K & Chen JN (2011) Mutation in utp15 disrupts vascular patterning in a p53-dependent manner in zebrafish embryos. PLoS One 6: e25013 PubMed GONUTS page
↑ Liu TX et al. (2003) Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Dev Cell 5: 903-14 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Plaster N et al. (2006) p53 deficiency rescues apoptosis and differentiation of multiple cell types in zebrafish flathead mutants deficient for zygotic DNA polymerase delta1. Cell Death Differ 13: 223-35 PubMed GONUTS page
↑ Ghiselli G (2006) SMC3 knockdown triggers genomic instability and p53-dependent apoptosis in human and zebrafish cells. Mol Cancer 5: 52 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Robu ME et al. (2007) p53 activation by knockdown technologies. PLoS Genet 3: e78 PubMed GONUTS page
↑ Mei J et al. (2008) C1q-like inhibits p53-mediated apoptosis and controls normal hematopoiesis during zebrafish embryogenesis. Dev Biol 319: 273-84 PubMed GONUTS page
↑ Anderson RM et al. (2009) Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration. Dev Biol 334: 213-23 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Parant JM et al. (2010) Genetic modeling of Li-Fraumeni syndrome in zebrafish. Dis Model Mech 3: 45-56 PubMed GONUTS page
↑ Kratz E et al. (2006) Functional characterization of the Bcl-2 gene family in the zebrafish. Cell Death Differ 13: 1631-40 PubMed GONUTS page
↑ Campbell WA et al. (2006) Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. J Neurochem 96: 1423-40 PubMed GONUTS page
↑ Chen J et al. (2005) Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes Dev 19: 2900-11 PubMed GONUTS page
↑ Lee H & Kimelman D (2002) A dominant-negative form of p63 is required for epidermal proliferation in zebrafish. Dev Cell 2: 607-16 PubMed GONUTS page
↑ Gonzalez P et al. (2005) Comparative effects of dietary methylmercury on gene expression in liver, skeletal muscle, and brain of the zebrafish (Danio rerio). Environ Sci Technol 39: 3972-80 PubMed GONUTS page
↑ ^21.0 ^21.1 Dovey M et al. (2009) Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish. Zebrafish 6: 397-404 PubMed GONUTS page
↑ ^22.0 ^22.1 Feng X et al. (2011) p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO J 30: 3397-415 PubMed GONUTS page

[PMID:15630097-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Berghmans S et al. (2005) tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A 102: 407-12 PubMed GONUTS page

[PMID:15590746-1] 2.0 ^2.1 ^2.2 Ninkovic J et al. (2005) Inhibition of neurogenesis at the zebrafish midbrain-hindbrain boundary by the combined and dose-dependent activity of a new hairy/E(spl) gene pair. Development 132: 75-88 PubMed GONUTS page

[PMID:15914672-2] 3.0 ^3.1 Bladen CL et al. (2005) DNA damage response and Ku80 function in the vertebrate embryo. Nucleic Acids Res 33: 3002-10 PubMed GONUTS page

[PMID:18510930-3] 4.0 ^4.1 Sidi S et al. (2008) Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 133: 864-77 PubMed GONUTS page

[PMID:21209837-4] Danilova N et al. (2010) p53 upregulation is a frequent response to deficiency of cell-essential genes. PLoS One 5: e15938 PubMed GONUTS page

[PMID:15529176-5] 6.0 ^6.1 Nowak M et al. (2005) Perp is required for tissue-specific cell survival during zebrafish development. Cell Death Differ 12: 52-64 PubMed GONUTS page

[PMID:18418056-6] 7.0 ^7.1 Davidson W et al. (2008) Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos. Cell Cycle 7: 1224-30 PubMed GONUTS page

[PMID:21949834-7] Mouillesseaux K & Chen JN (2011) Mutation in utp15 disrupts vascular patterning in a p53-dependent manner in zebrafish embryos. PLoS One 6: e25013 PubMed GONUTS page

[PMID:14667412-8] Liu TX et al. (2003) Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Dev Cell 5: 903-14 PubMed GONUTS page

[PMID:16096653-9] 10.0 ^10.1 ^10.2 ^10.3 Plaster N et al. (2006) p53 deficiency rescues apoptosis and differentiation of multiple cell types in zebrafish flathead mutants deficient for zygotic DNA polymerase delta1. Cell Death Differ 13: 223-35 PubMed GONUTS page

[PMID:17081288-10] Ghiselli G (2006) SMC3 knockdown triggers genomic instability and p53-dependent apoptosis in human and zebrafish cells. Mol Cancer 5: 52 PubMed GONUTS page

[PMID:17530925-11] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Robu ME et al. (2007) p53 activation by knockdown technologies. PLoS Genet 3: e78 PubMed GONUTS page

[PMID:18514183-12] Mei J et al. (2008) C1q-like inhibits p53-mediated apoptosis and controls normal hematopoiesis during zebrafish embryogenesis. Dev Biol 319: 273-84 PubMed GONUTS page

[PMID:19631206-13] Anderson RM et al. (2009) Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration. Dev Biol 334: 213-23 PubMed GONUTS page

[PMID:20075382-14] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Parant JM et al. (2010) Genetic modeling of Li-Fraumeni syndrome in zebrafish. Dis Model Mech 3: 45-56 PubMed GONUTS page

[PMID:16888646-15] Kratz E et al. (2006) Functional characterization of the Bcl-2 gene family in the zebrafish. Cell Death Differ 13: 1631-40 PubMed GONUTS page

[PMID:16464238-16] Campbell WA et al. (2006) Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. J Neurochem 96: 1423-40 PubMed GONUTS page

[PMID:16322560-17] Chen J et al. (2005) Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes Dev 19: 2900-11 PubMed GONUTS page

[PMID:12015968-18] Lee H & Kimelman D (2002) A dominant-negative form of p63 is required for epidermal proliferation in zebrafish. Dev Cell 2: 607-16 PubMed GONUTS page

[PMID:15984772-19] Gonzalez P et al. (2005) Comparative effects of dietary methylmercury on gene expression in liver, skeletal muscle, and brain of the zebrafish (Danio rerio). Environ Sci Technol 39: 3972-80 PubMed GONUTS page

[PMID:19954345-20] 21.0 ^21.1 Dovey M et al. (2009) Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish. Zebrafish 6: 397-404 PubMed GONUTS page

[PMID:21792176-21] 22.0 ^22.1 Feng X et al. (2011) p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO J 30: 3397-415 PubMed GONUTS page

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Species (Taxon ID)	Danio rerio (zebrafish) (taxon:7955)
Gene Name(s)	tp53
Protein Name(s)	tumor protein p53,
External Links
ZFIN	ZDB-GENE-990415-270

ZFIN:tp53

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