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ZFIN:tnnt2a

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Contents

Species (Taxon ID) Danio rerio (zebrafish) (taxon:7955)
Gene Name(s) tnnt2a
Protein Name(s) troponin T2a, cardiac,
External Links
ZFIN ZDB-GENE-000626-1

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003779

actin binding

ZFIN:ZDB-PUB-040216-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P45379

F

From ZFIN

GO:0005200

structural constituent of cytoskeleton

ZFIN:ZDB-PUB-040216-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P50752

F

From ZFIN

GO:0005523

tropomyosin binding

ZFIN:ZDB-PUB-040216-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P45379

F

From ZFIN

GO:0005737

cytoplasm

ZFIN:ZDB-PUB-040216-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P50752

C

From ZFIN

GO:0005861

troponin complex

ZFIN:ZDB-PUB-020514-12
PMID:11967535[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-320

C

From ZFIN

GO:0006936

muscle contraction

ZFIN:ZDB-PUB-040216-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P50752

P

From ZFIN

GO:0006941

striated muscle contraction

ZFIN:ZDB-PUB-020514-12
PMID:11967535[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-320

P

From ZFIN

GO:0007507

heart development

ZFIN:ZDB-PUB-080801-6
PMID:18660518[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060317-4

P

From ZFIN

GO:0008015

blood circulation

ZFIN:ZDB-PUB-060616-30
PMID:16753140[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060317-4

P

From ZFIN

GO:0008015

blood circulation

ZFIN:ZDB-PUB-080422-4
PMID:18417622[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060317-4

P

From ZFIN

GO:0008015

blood circulation

ZFIN:ZDB-PUB-080515-7
PMID:18469344[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060317-4

P

From ZFIN

GO:0008016

regulation of heart contraction

ZFIN:ZDB-PUB-110124-3
PMID:21245263[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060317-4

P

From ZFIN

GO:0008016

regulation of heart contraction

ZFIN:ZDB-PUB-110124-3
PMID:21245263[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-110616-1

P

From ZFIN

GO:0008092

cytoskeletal protein binding

ZFIN:ZDB-PUB-040216-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P45379

F

From ZFIN

GO:0010749

regulation of nitric oxide mediated signal transduction

ZFIN:ZDB-PUB-090526-18
PMID:19450519[7]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0030016

myofibril

ZFIN:ZDB-PUB-040216-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P50752

C

From ZFIN

GO:0030017

sarcomere

ZFIN:ZDB-PUB-040216-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P50752

C

From ZFIN

GO:0030674

protein binding, bridging

ZFIN:ZDB-PUB-040216-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P50753

F

From ZFIN

GO:0045214

sarcomere organization

ZFIN:ZDB-PUB-020514-12
PMID:11967535[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-320

P

From ZFIN

GO:0048793

pronephros development

ZFIN:ZDB-PUB-060616-30
PMID:16753140[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060317-4

P

From ZFIN

GO:0048845

venous blood vessel morphogenesis

ZFIN:ZDB-PUB-091023-30
PMID:19815777[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060317-4

P

From ZFIN

GO:0055009

atrial cardiac muscle tissue morphogenesis

ZFIN:ZDB-PUB-040216-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P50752

P

From ZFIN

GO:0055010

ventricular cardiac muscle tissue morphogenesis

ZFIN:ZDB-PUB-040216-1

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P50752

P

From ZFIN

GO:0055010

ventricular cardiac muscle tissue morphogenesis

ZFIN:ZDB-PUB-110124-3
PMID:21245263[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-110616-1

P

From ZFIN

GO:0060047

heart contraction

ZFIN:ZDB-PUB-070711-4
PMID:17592134[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060317-4

P

From ZFIN

GO:0060047

heart contraction

ZFIN:ZDB-PUB-090526-18
PMID:19450519[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-120201-6

P

From ZFIN

GO:0060047

heart contraction

ZFIN:ZDB-PUB-091023-12
PMID:19800866[10]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060317-4

P

From ZFIN

GO:0060047

heart contraction

ZFIN:ZDB-PUB-970210-25
PMID:9007249[11]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070808-2

P

From ZFIN

GO:0060047

heart contraction

ZFIN:ZDB-PUB-970210-25
PMID:9007249[11]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1038

P

From ZFIN

GO:0060218

hemopoietic stem cell differentiation

ZFIN:ZDB-PUB-090526-18
PMID:19450519[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-120201-6

P

From ZFIN

GO:0060840

artery development

ZFIN:ZDB-PUB-090526-18
PMID:19450519[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-120201-6

P

From ZFIN


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Sehnert AJ et al. (2002) Cardiac troponin T is essential in sarcomere assembly and cardiac contractility. Nat Genet 31: 106-10 PubMed GONUTS page
  2. Grimes AC et al. (2008) PCB126 exposure disrupts zebrafish ventricular and branchial but not early neural crest development. Toxicol Sci 106: 193-205 PubMed GONUTS page
  3. 3.0 3.1 Liu YW & Guo L (2006) Endothelium is required for the promotion of interrenal morphogenetic movement during early zebrafish development. Dev Biol 297: 44-58 PubMed GONUTS page
  4. Bertrand JY et al. (2008) CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis. Development 135: 1853-62 PubMed GONUTS page
  5. Hogan BM et al. (2008) ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish. Hum Mol Genet 17: 2424-32 PubMed GONUTS page
  6. 6.0 6.1 6.2 Becker JR et al. (2011) Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish. Dis Model Mech 4: 400-10 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 North TE et al. (2009) Hematopoietic stem cell development is dependent on blood flow. Cell 137: 736-48 PubMed GONUTS page
  8. Herbert SP et al. (2009) Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science 326: 294-8 PubMed GONUTS page
  9. Arnaout R et al. (2007) Zebrafish model for human long QT syndrome. Proc Natl Acad Sci U S A 104: 11316-21 PubMed GONUTS page
  10. Vogel B et al. (2009) In-vivo characterization of human dilated cardiomyopathy genes in zebrafish. Biochem Biophys Res Commun 390: 516-22 PubMed GONUTS page
  11. 11.0 11.1 Chen JN et al. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development 123: 293-302 PubMed GONUTS page


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