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ZFIN:tbx5

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Contents

Species (Taxon ID) Danio rerio (zebrafish) (taxon:7955)
Gene Name(s) tbx5
Protein Name(s) T-box 5,
External Links
ZFIN ZDB-GENE-991124-7

Annotations

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0001947

heart looping

ZFIN:ZDB-PUB-030115-4
PMID:12399308[1]

IMP: Inferred from Mutant Phenotype

P

From ZFIN

GO:0003344

pericardium morphogenesis

ZFIN:ZDB-PUB-030115-4
PMID:12399308[1]

IMP: Inferred from Mutant Phenotype

P

From ZFIN

GO:0003677

DNA binding

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

From ZFIN

GO:0003677

DNA binding

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

From ZFIN

GO:0003700

transcription factor activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001699

F

From ZFIN

GO:0003700

transcription factor activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR008967

F

From ZFIN

GO:0003700

transcription factor activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR018186

F

From ZFIN

GO:0003700

transcription factor activity

ZFIN:ZDB-PUB-080326-29
PMID:18347092[2]

IDA: Inferred from Direct Assay

F

From ZFIN

GO:0005634

nucleus

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

From ZFIN

GO:0005634

nucleus

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

From ZFIN

GO:0005634

nucleus

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001699

C

From ZFIN

GO:0005634

nucleus

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR018186

C

From ZFIN

GO:0006350

transcription

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

From ZFIN

GO:0006350

transcription

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

From ZFIN

GO:0006355

regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001699

P

From ZFIN

GO:0006355

regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR018186

P

From ZFIN

GO:0007507

heart development

ZFIN:ZDB-PUB-080801-8
PMID:18661250[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060328-2

P

From ZFIN

GO:0007507

heart development

ZFIN:ZDB-PUB-080801-8
PMID:18661250[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-090227-1

P

From ZFIN

GO:0007507

heart development

ZFIN:ZDB-PUB-090217-21
PMID:19204083[4]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-060328-2
ZFIN:ZDB-MRPHLNO-091230-1

P

From ZFIN

GO:0030528

transcription regulator activity

ZFIN:ZDB-PUB-060313-3
PMID:16501170[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060328-2

F

From ZFIN

GO:0030528

transcription regulator activity

ZFIN:ZDB-PUB-080415-16
PMID:18407257[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080813-1

F

From ZFIN

GO:0030528

transcription regulator activity

ZFIN:ZDB-PUB-080415-16
PMID:18407257[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060328-2

F

From ZFIN

GO:0035050

embryonic heart tube development

ZFIN:ZDB-PUB-080415-16
PMID:18407257[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080813-1

P

From ZFIN

GO:0035050

embryonic heart tube development

ZFIN:ZDB-PUB-080415-16
PMID:18407257[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060328-2

P

From ZFIN

GO:0035118

embryonic pectoral fin morphogenesis

ZFIN:ZDB-PUB-030115-4
PMID:12399308[1]

IMP: Inferred from Mutant Phenotype

P

From ZFIN

GO:0035118

embryonic pectoral fin morphogenesis

ZFIN:ZDB-PUB-030115-4
PMID:12399308[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-030627-1

P

From ZFIN

GO:0043193

positive regulation of gene-specific transcription

ZFIN:ZDB-PUB-080326-29
PMID:18347092[2]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0043565

sequence-specific DNA binding

ZFIN:ZDB-PUB-080326-29
PMID:18347092[2]

IDA: Inferred from Direct Assay

F

From ZFIN

GO:0045449

regulation of transcription

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

From ZFIN

GO:0045449

regulation of transcription

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

From ZFIN

GO:0045449

regulation of transcription

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR008967

P

From ZFIN

GO:0045449

regulation of transcription

ZFIN:ZDB-PUB-080801-8
PMID:18661250[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060328-2

P

From ZFIN

GO:0045893

positive regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-080415-16
PMID:18407257[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-080813-1

P

From ZFIN

GO:0045893

positive regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-080415-16
PMID:18407257[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060328-2

P

From ZFIN

GO:0060174

limb bud formation

ZFIN:ZDB-PUB-020624-8
PMID:12066188[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060328-3

P

From ZFIN


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 Ng JK et al. (2002) The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10. Development 129: 5161-70 PubMed GONUTS page
  2. 2.0 2.1 2.2 Chi NC et al. (2008) Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes Dev 22: 734-9 PubMed GONUTS page
  3. 3.0 3.1 3.2 Lu JH et al. (2008) Cascade effect of cardiac myogenesis gene expression during cardiac looping in tbx5 knockdown zebrafish embryos. J Biomed Sci 15: 779-87 PubMed GONUTS page
  4. Ghosh TK et al. (2009) Physical interaction between TBX5 and MEF2C is required for early heart development. Mol Cell Biol 29: 2205-18 PubMed GONUTS page
  5. Harvey SA & Logan MP (2006) sall4 acts downstream of tbx5 and is required for pectoral fin outgrowth. Development 133: 1165-73 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Qu X et al. (2008) Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish. Dev Biol 317: 486-96 PubMed GONUTS page
  7. Ahn DG et al. (2002) T-box gene tbx5 is essential for formation of the pectoral limb bud. Nature 417: 754-8 PubMed GONUTS page
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