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ZFIN:spast
Contents |
| Species (Taxon ID) | Danio rerio (zebrafish) (taxon:7955) | |
| Gene Name(s) | spast | |
| Protein Name(s) | spastin, | |
| External Links | ||
| ZFIN | ZDB-GENE-040426-2331 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
ZFIN:ZDB-PUB-020723-1 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From ZFIN |
||
| GO:0000166 |
nucleotide binding |
ZFIN:ZDB-PUB-020724-1 |
IEA: Inferred from Electronic Annotation |
F |
From ZFIN |
|||
| GO:0001578 |
microtubule bundle formation |
ZFIN:ZDB-PUB-110105-1 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From ZFIN |
|||
| GO:0005524 |
ATP binding |
ZFIN:ZDB-PUB-020723-1 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From ZFIN |
||
| GO:0005524 |
ATP binding |
ZFIN:ZDB-PUB-020724-1 |
IEA: Inferred from Electronic Annotation |
F |
From ZFIN |
|||
| GO:0005524 |
ATP binding |
ZFIN:ZDB-PUB-020724-1 |
IEA: Inferred from Electronic Annotation |
F |
From ZFIN |
|||
| GO:0005634 |
nucleus |
ZFIN:ZDB-PUB-020723-1 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0539 |
C |
From ZFIN |
||
| GO:0005634 |
nucleus |
ZFIN:ZDB-PUB-120306-2 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0191 |
C |
From ZFIN |
||
| GO:0005737 |
cytoplasm |
ZFIN:ZDB-PUB-020723-1 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From ZFIN |
||
| GO:0005815 |
microtubule organizing center |
ZFIN:ZDB-PUB-120306-2 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0048 |
C |
From ZFIN |
||
| GO:0005856 |
cytoskeleton |
ZFIN:ZDB-PUB-020723-1 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From ZFIN |
||
| GO:0005874 |
microtubule |
ZFIN:ZDB-PUB-020723-1 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0493 |
C |
From ZFIN |
||
| GO:0007049 |
cell cycle |
ZFIN:ZDB-PUB-020723-1 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0131 |
P |
From ZFIN |
||
| GO:0007275 |
multicellular organismal development |
ZFIN:ZDB-PUB-020723-1 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From ZFIN |
||
| GO:0007399 |
nervous system development |
ZFIN:ZDB-PUB-020723-1 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0524 |
P |
From ZFIN |
||
| GO:0008017 |
microtubule binding |
ZFIN:ZDB-PUB-110105-1 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From ZFIN |
|||
| GO:0008568 |
microtubule-severing ATPase activity |
ZFIN:ZDB-PUB-020724-1 |
IEA: Inferred from Electronic Annotation |
F |
From ZFIN |
|||
| GO:0008568 |
microtubule-severing ATPase activity |
ZFIN:ZDB-PUB-031118-3 |
IEA: Inferred from Electronic Annotation |
F |
From ZFIN |
|||
| GO:0008568 |
microtubule-severing ATPase activity |
ZFIN:ZDB-PUB-110105-1 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From ZFIN |
|||
| GO:0016020 |
membrane |
ZFIN:ZDB-PUB-020723-1 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From ZFIN |
||
| GO:0016021 |
integral to membrane |
ZFIN:ZDB-PUB-020723-1 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From ZFIN |
||
| GO:0016787 |
hydrolase activity |
ZFIN:ZDB-PUB-020723-1 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From ZFIN |
||
| GO:0017111 |
nucleoside-triphosphatase activity |
ZFIN:ZDB-PUB-020724-1 |
IEA: Inferred from Electronic Annotation |
F |
From ZFIN |
|||
| GO:0021955 |
central nervous system neuron axonogenesis |
ZFIN:ZDB-PUB-060816-16 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-061004-1 |
P |
From ZFIN |
||
| GO:0030154 |
cell differentiation |
ZFIN:ZDB-PUB-020723-1 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0221 |
P |
From ZFIN |
||
| GO:0031117 |
positive regulation of microtubule depolymerization |
ZFIN:ZDB-PUB-060816-16 |
IMP: Inferred from Mutant Phenotype |
P |
From ZFIN |
|||
| GO:0031122 |
cytoplasmic microtubule organization |
ZFIN:ZDB-PUB-100929-7 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-061004-2 |
P |
From ZFIN |
||
| GO:0034214 |
protein hexamerization |
ZFIN:ZDB-PUB-110105-1 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From ZFIN |
|||
| GO:0043014 |
alpha-tubulin binding |
ZFIN:ZDB-PUB-110105-1 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From ZFIN |
|||
| GO:0043066 |
negative regulation of apoptotic process |
ZFIN:ZDB-PUB-060816-16 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-061004-1 |
P |
From ZFIN |
||
| GO:0045773 |
positive regulation of axon extension |
ZFIN:ZDB-PUB-060816-16 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-061004-1 |
P |
From ZFIN |
||
| GO:0048471 |
perinuclear region of cytoplasm |
ZFIN:ZDB-PUB-120306-2 |
IEA: Inferred from Electronic Annotation |
UniProtKB-SubCell:SL-0198 |
C |
From ZFIN |
||
| GO:0048487 |
beta-tubulin binding |
ZFIN:ZDB-PUB-110105-1 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From ZFIN |
|||
| GO:0048676 |
axon extension involved in development |
ZFIN:ZDB-PUB-100929-7 |
IGI: Inferred from Genetic Interaction |
ZFIN:ZDB-MRPHLNO-061004-1 |
P |
From ZFIN |
||
| GO:0048676 |
axon extension involved in development |
ZFIN:ZDB-PUB-100929-7 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-061004-1 |
P |
From ZFIN |
||
| GO:0051013 |
microtubule severing |
ZFIN:ZDB-PUB-110105-1 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From ZFIN |
|||
| GO:0051260 |
protein homooligomerization |
ZFIN:ZDB-PUB-110105-1 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From ZFIN |
|||
| GO:0051301 |
cell division |
ZFIN:ZDB-PUB-020723-1 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0132 |
P |
From ZFIN |
||
|
NOT |
GO:0007416 |
synapse assembly |
ZFIN:ZDB-PUB-060816-16 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-061004-1 |
P |
From ZFIN |
|
|
colocalizes_with |
GO:0015630 |
microtubule cytoskeleton |
ZFIN:ZDB-PUB-110105-1 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From ZFIN |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Wood JD et al. (2006) The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo. Hum Mol Genet 15: 2763-71 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Butler R et al. (2010) Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia. Dis Model Mech 3: 743-51 PubMed GONUTS page
