ZFIN:smo

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001570	vasculogenesis	ZFIN:ZDB-PUB-080408-9 PMID:18377889^[1]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-080605-1	P	From ZFIN
	GO:0001649	osteoblast differentiation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN4	P	From ZFIN
	GO:0001755	neural crest cell migration	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN3	P	From ZFIN
	GO:0001839	neural plate morphogenesis	ZFIN:ZDB-PUB-060313-5 PMID:16502420^[2]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0001947	heart looping	ZFIN:ZDB-PUB-110523-31 PMID:21558385^[3]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-070918-2	P	From ZFIN
	GO:0002052	positive regulation of neuroblast proliferation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN1	P	From ZFIN
	GO:0002053	positive regulation of mesenchymal cell proliferation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN2	P	From ZFIN
	GO:0003007	heart morphogenesis	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN1	P	From ZFIN
	GO:0003231	cardiac ventricle development	ZFIN:ZDB-PUB-110523-31 PMID:21558385^[3]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-070918-2	P	From ZFIN
	GO:0004871	signal transducer activity	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0807	F	From ZFIN
	GO:0004872	receptor activity	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From ZFIN
	GO:0004888	transmembrane signaling receptor activity	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	F	From ZFIN
	GO:0004930	G-protein coupled receptor activity	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0297	F	From ZFIN
	GO:0005737	cytoplasm	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN0	C	From ZFIN
	GO:0005886	plasma membrane	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN0	C	From ZFIN
	GO:0005929	cilium	ZFIN:ZDB-PUB-050907-11 PMID:16136078^[4]	ISS: Inferred from Sequence or Structural Similarity	RefSeq:NP_795970	C	From ZFIN
	GO:0005929	cilium	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN1	C	From ZFIN
	GO:0007165	signal transduction	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0807	P	From ZFIN
	GO:0007166	cell surface receptor signaling pathway	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR000539	P	From ZFIN
	GO:0007166	cell surface receptor signaling pathway	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	P	From ZFIN
	GO:0007186	G-protein coupled receptor signaling pathway	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0297	P	From ZFIN
	GO:0007224	smoothened signaling pathway	ZFIN:ZDB-PUB-010814-7 PMID:11493557^[5]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-011018-1	P	From ZFIN
	GO:0007224	smoothened signaling pathway	ZFIN:ZDB-PUB-010814-7 PMID:11493557^[5]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-011018-2	P	From ZFIN
	GO:0007224	smoothened signaling pathway	ZFIN:ZDB-PUB-010927-3 PMID:11566855^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0007224	smoothened signaling pathway	ZFIN:ZDB-PUB-010927-3 PMID:11566855^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-990422-74	P	From ZFIN
	GO:0007275	multicellular organismal development	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From ZFIN
	GO:0007283	spermatogenesis	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN4	P	From ZFIN
	GO:0007368	determination of left/right symmetry	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN1	P	From ZFIN
	GO:0007399	nervous system development	ZFIN:ZDB-PUB-030919-9 PMID:13129844^[7]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0007411	axon guidance	ZFIN:ZDB-PUB-091023-70 PMID:19846707^[8]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-070227-2	P	From ZFIN
	GO:0007417	central nervous system development	ZFIN:ZDB-PUB-100910-14 PMID:20806318^[9]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-101119-5	P	From ZFIN
	GO:0007517	muscle organ development	ZFIN:ZDB-PUB-041228-26 PMID:15618520^[10]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-040129-3	P	From ZFIN
	GO:0007517	muscle organ development	ZFIN:ZDB-PUB-061020-53 PMID:17046741^[11]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-070227-2	P	From ZFIN
	GO:0008406	gonad development	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN0	P	From ZFIN
	GO:0009880	embryonic pattern specification	ZFIN:ZDB-PUB-030805-6 PMID:12889061^[12]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0009952	anterior/posterior pattern specification	ZFIN:ZDB-PUB-030304-16 PMID:12588855^[13]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0010002	cardioblast differentiation	ZFIN:ZDB-PUB-081022-5 PMID:18842815^[14]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-090325-3	P	From ZFIN
	GO:0014003	oligodendrocyte development	ZFIN:ZDB-PUB-020812-2 PMID:12167410^[15]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0014033	neural crest cell differentiation	ZFIN:ZDB-PUB-060313-5 PMID:16502420^[2]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0016020	membrane	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From ZFIN
	GO:0016020	membrane	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR000539	C	From ZFIN
	GO:0016020	membrane	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	C	From ZFIN
	GO:0016021	integral to membrane	ZFIN:ZDB-PUB-020723-1	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From ZFIN
	GO:0017147	Wnt-protein binding	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN0	F	From ZFIN
	GO:0021508	floor plate formation	ZFIN:ZDB-PUB-030115-17 PMID:12508225^[16]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0021520	spinal cord motor neuron cell fate specification	ZFIN:ZDB-PUB-020812-2 PMID:12167410^[15]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0021523	somatic motor neuron differentiation	ZFIN:ZDB-PUB-010814-7 PMID:11493557^[5]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-011018-1	P	From ZFIN
	GO:0021523	somatic motor neuron differentiation	ZFIN:ZDB-PUB-010814-7 PMID:11493557^[5]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-011018-2	P	From ZFIN
	GO:0021523	somatic motor neuron differentiation	ZFIN:ZDB-PUB-010927-3 PMID:11566855^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0021523	somatic motor neuron differentiation	ZFIN:ZDB-PUB-010927-3 PMID:11566855^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-990422-74	P	From ZFIN
	GO:0021536	diencephalon development	ZFIN:ZDB-PUB-080327-9 PMID:18358464^[17]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENO-080605-1 ZFIN:ZDB-MRPHLNO-070522-3	P	From ZFIN
	GO:0021537	telencephalon development	ZFIN:ZDB-PUB-010315-8 PMID:11239427^[18]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-080605-1	P	From ZFIN
	GO:0021561	facial nerve development	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN4	P	From ZFIN
	GO:0021587	cerebellum morphogenesis	ZFIN:ZDB-PUB-080422-14 PMID:18423594^[19]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-080605-1	P	From ZFIN
	GO:0021696	cerebellar cortex morphogenesis	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN1	P	From ZFIN
	GO:0021782	glial cell development	ZFIN:ZDB-PUB-100910-14 PMID:20806318^[9]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-101119-5	P	From ZFIN
	GO:0021798	forebrain dorsal/ventral pattern formation	ZFIN:ZDB-PUB-010927-3 PMID:11566855^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0021798	forebrain dorsal/ventral pattern formation	ZFIN:ZDB-PUB-010927-3 PMID:11566855^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-990422-74	P	From ZFIN
	GO:0021904	dorsal/ventral neural tube patterning	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN2	P	From ZFIN
	GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN4	P	From ZFIN
	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN1	P	From ZFIN
	GO:0021953	central nervous system neuron differentiation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN4	P	From ZFIN
	GO:0021984	adenohypophysis development	ZFIN:ZDB-PUB-030304-4 PMID:12606279^[20]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0030165	PDZ domain binding	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN0	F	From ZFIN
	GO:0030182	neuron differentiation	ZFIN:ZDB-PUB-071210-37 PMID:18060804^[21]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-080605-1	P	From ZFIN
	GO:0030239	myofibril assembly	ZFIN:ZDB-PUB-041202-3 PMID:15572133^[22]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0030900	forebrain development	ZFIN:ZDB-PUB-041111-21 PMID:15533825^[23]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0030902	hindbrain development	ZFIN:ZDB-PUB-040804-3 PMID:15281067^[24]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0031016	pancreas development	ZFIN:ZDB-PUB-010905-3 PMID:11553330^[25]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0031016	pancreas development	ZFIN:ZDB-PUB-050803-9 PMID:16055112^[26]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0031017	exocrine pancreas development	ZFIN:ZDB-PUB-060302-14 PMID:16490192^[27]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0031018	endocrine pancreas development	ZFIN:ZDB-PUB-020402-4 PMID:11900460^[28]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-070918-2	P	From ZFIN
	GO:0031018	endocrine pancreas development	ZFIN:ZDB-PUB-080421-3 PMID:18410733^[29]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-080507-1	P	From ZFIN
	GO:0031076	embryonic camera-type eye development	ZFIN:ZDB-PUB-050506-5 PMID:15857917^[30]	IDA: Inferred from Direct Assay		P	From ZFIN
	GO:0031102	neuron projection regeneration	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN1	P	From ZFIN
	GO:0031290	retinal ganglion cell axon guidance	ZFIN:ZDB-PUB-100910-14 PMID:20806318^[9]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-101119-5	P	From ZFIN
	GO:0032474	otolith morphogenesis	ZFIN:ZDB-PUB-070629-12 PMID:17574823^[31]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-071114-15	P	From ZFIN
	GO:0035143	caudal fin morphogenesis	ZFIN:ZDB-PUB-070711-11 PMID:17597528^[32]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-080418-1	P	From ZFIN
	GO:0035270	endocrine system development	ZFIN:ZDB-PUB-050426-1 PMID:15728669^[33]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0035479	angioblast cell migration from lateral mesoderm to midline	ZFIN:ZDB-PUB-100309-8 PMID:20193674^[34]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-011018-2	P	From ZFIN
	GO:0035912	dorsal aorta morphogenesis	ZFIN:ZDB-PUB-100309-8 PMID:20193674^[34]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-011018-2	P	From ZFIN
	GO:0042472	inner ear morphogenesis	ZFIN:ZDB-PUB-070629-12 PMID:17574823^[31]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-071114-15	P	From ZFIN
	GO:0042475	odontogenesis of dentin-containing tooth	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN4	P	From ZFIN
	GO:0042693	muscle cell fate commitment	ZFIN:ZDB-PUB-041008-3 PMID:15464578^[35]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0042693	muscle cell fate commitment	ZFIN:ZDB-PUB-050907-11 PMID:16136078^[4]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0042813	Wnt-activated receptor activity	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN0	F	From ZFIN
	GO:0043025	neuronal cell body	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN1	C	From ZFIN
	GO:0043066	negative regulation of apoptotic process	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN1	P	From ZFIN
	GO:0045880	positive regulation of smoothened signaling pathway	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN1	P	From ZFIN
	GO:0048557	embryonic digestive tract morphogenesis	ZFIN:ZDB-PUB-090106-43 PMID:19123126^[36]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-070918-2	P	From ZFIN
	GO:0048663	neuron fate commitment	ZFIN:ZDB-PUB-060313-5 PMID:16502420^[2]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0048702	embryonic neurocranium morphogenesis	ZFIN:ZDB-PUB-050803-5 PMID:16049113^[37]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0048703	embryonic viscerocranium morphogenesis	ZFIN:ZDB-PUB-060412-2 PMID:16580747^[38]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0048703	embryonic viscerocranium morphogenesis	ZFIN:ZDB-PUB-100726-23 PMID:16481351^[39]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-110830-1	P	From ZFIN
	GO:0048741	skeletal muscle fiber development	ZFIN:ZDB-PUB-101222-7 PMID:21147088^[40]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-080605-1	P	From ZFIN
	GO:0048745	smooth muscle tissue development	ZFIN:ZDB-PUB-110523-31 PMID:21558385^[3]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-070918-2	P	From ZFIN
	GO:0048752	semicircular canal morphogenesis	ZFIN:ZDB-PUB-070629-12 PMID:17574823^[31]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-071114-15	P	From ZFIN
	GO:0048794	swim bladder development	ZFIN:ZDB-PUB-110512-12 PMID:21479192^[41]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-080605-1	P	From ZFIN
	GO:0048795	swim bladder morphogenesis	ZFIN:ZDB-PUB-090511-18 PMID:19422819^[42]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-080605-1	P	From ZFIN
	GO:0048839	inner ear development	ZFIN:ZDB-PUB-030304-16 PMID:12588855^[13]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0048846	axon extension involved in axon guidance	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN1	P	From ZFIN
	GO:0050679	positive regulation of epithelial cell proliferation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN2	P	From ZFIN
	GO:0051216	cartilage development	ZFIN:ZDB-PUB-100726-23 PMID:16481351^[39]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-110830-1	P	From ZFIN
	GO:0055002	striated muscle cell development	ZFIN:ZDB-PUB-000505-14 PMID:10769242^[43]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0055002	striated muscle cell development	ZFIN:ZDB-PUB-000505-14 PMID:10769242^[43]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-990422-74	P	From ZFIN
	GO:0060041	retina development in camera-type eye	ZFIN:ZDB-PUB-030210-6 PMID:12538521^[44]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-050209-29	P	From ZFIN
	GO:0060070	canonical Wnt receptor signaling pathway	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR11309_AN0	P	From ZFIN
	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway	ZFIN:ZDB-PUB-090526-31 PMID:19464178^[45]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-100512-7	P	From ZFIN
	GO:0060844	arterial endothelial cell fate commitment	ZFIN:ZDB-PUB-100309-8 PMID:20193674^[34]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-011018-2	P	From ZFIN
	GO:0060896	neural plate pattern specification	ZFIN:ZDB-PUB-010927-3 PMID:11566855^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-000821-1	P	From ZFIN
	GO:0060896	neural plate pattern specification	ZFIN:ZDB-PUB-010927-3 PMID:11566855^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-990422-74	P	From ZFIN
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Pendeville H et al. (2008) Zebrafish Sox7 and Sox18 function together to control arterial-venous identity. Dev Biol 317: 405-16 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Takamiya M & Campos-Ortega JA (2006) Hedgehog signalling controls zebrafish neural keel morphogenesis via its level-dependent effects on neurogenesis. Dev Dyn 235: 978-97 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Hami D et al. (2011) Zebrafish cardiac development requires a conserved secondary heart field. Development 138: 2389-98 PubMed GONUTS page
↑ ^4.0 ^4.1 Corbit KC et al. (2005) Vertebrate Smoothened functions at the primary cilium. Nature 437: 1018-21 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Chen W et al. (2001) Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity. Development 128: 2385-96 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Varga ZM et al. (2001) Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development 128: 3497-509 PubMed GONUTS page
↑ Ungos JM et al. (2003) Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons. Development 130: 5351-62 PubMed GONUTS page
↑ Paulus JD et al. (2009) Muscle contractions guide rohon-beard peripheral sensory axons. J Neurosci 29: 13190-201 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Barresi MJ et al. (2010) Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Dev Dyn 239: 2603-18 PubMed GONUTS page
↑ Wilbanks AM et al. (2004) Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. Science 306: 2264-7 PubMed GONUTS page
↑ Feng X et al. (2006) Hedgehog acts directly on the zebrafish dermomyotome to promote myogenic differentiation. Dev Biol 300: 736-46 PubMed GONUTS page
↑ Tallafuss A et al. (2003) Selective control of neuronal cluster size at the forebrain/midbrain boundary by signaling from the prechordal plate. Dev Dyn 227: 524-35 PubMed GONUTS page
↑ ^13.0 ^13.1 Hammond KL et al. (2003) Hedgehog signalling is required for correct anteroposterior patterning of the zebrafish otic vesicle. Development 130: 1403-17 PubMed GONUTS page
↑ Thomas NA et al. (2008) Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential. Development 135: 3789-99 PubMed GONUTS page
↑ ^15.0 ^15.1 Park HC et al. (2002) olig2 is required for zebrafish primary motor neuron and oligodendrocyte development. Dev Biol 248: 356-68 PubMed GONUTS page
↑ Albert S et al. (2003) Cyclops-independent floor plate differentiation in zebrafish embryos. Dev Dyn 226: 59-66 PubMed GONUTS page
↑ Sanek NA & Grinblat Y (2008) A novel role for zebrafish zic2a during forebrain development. Dev Biol 317: 325-35 PubMed GONUTS page
↑ Rohr KB et al. (2001) The nodal pathway acts upstream of hedgehog signaling to specify ventral telencephalic identity. Neuron 29: 341-51 PubMed GONUTS page
↑ McFarland KA et al. (2008) Hh and Wnt signaling regulate formation of olig2+ neurons in the zebrafish cerebellum. Dev Biol 318: 162-71 PubMed GONUTS page
↑ Sbrogna JL et al. (2003) Multiple roles for Hedgehog signaling in zebrafish pituitary development. Dev Biol 254: 19-35 PubMed GONUTS page
↑ Ke Z et al. (2008) Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment. Mol Cell Neurosci 37: 388-401 PubMed GONUTS page
↑ Henry CA & Amacher SL (2004) Zebrafish slow muscle cell migration induces a wave of fast muscle morphogenesis. Dev Cell 7: 917-23 PubMed GONUTS page
↑ Cheesman SE & Eisen JS (2004) gsh1 demarcates hypothalamus and intermediate spinal cord in zebrafish. Gene Expr Patterns 5: 107-12 PubMed GONUTS page
↑ Teraoka H et al. (2004) Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos. J Neurobiol 60: 275-88 PubMed GONUTS page
↑ Roy S et al. (2001) Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo. Curr Biol 11: 1358-63 PubMed GONUTS page
↑ Mavropoulos A et al. (2005) sox4b is a key player of pancreatic alpha cell differentiation in zebrafish. Dev Biol 285: 211-23 PubMed GONUTS page
↑ Wan H et al. (2006) Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter. Exp Cell Res 312: 1526-39 PubMed GONUTS page
↑ diIorio PJ et al. (2002) Sonic hedgehog is required early in pancreatic islet development. Dev Biol 244: 75-84 PubMed GONUTS page
↑ Chung WS & Stainier DY (2008) Intra-endodermal interactions are required for pancreatic beta cell induction. Dev Cell 14: 582-93 PubMed GONUTS page
↑ Kay JN et al. (2005) Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina. Development 132: 2573-85 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 Schibler A & Malicki J (2007) A screen for genetic defects of the zebrafish ear. Mech Dev 124: 592-604 PubMed GONUTS page
↑ Hadzhiev Y et al. (2007) Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish. BMC Dev Biol 7: 75 PubMed GONUTS page
↑ Dutta S et al. (2005) pitx3 defines an equivalence domain for lens and anterior pituitary placode. Development 132: 1579-90 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 Williams C et al. (2010) Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate. Dev Biol 341: 196-204 PubMed GONUTS page
↑ Hirsinger E et al. (2004) Hedgehog signaling is required for commitment but not initial induction of slow muscle precursors. Dev Biol 275: 143-57 PubMed GONUTS page
↑ Parkin CA et al. (2009) Hedgehog signalling is required for cloacal development in the zebrafish embryo. Int J Dev Biol 53: 45-57 PubMed GONUTS page
↑ Wada N et al. (2005) Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull. Development 132: 3977-88 PubMed GONUTS page
↑ Teraoka H et al. (2006) Impairment of lower jaw growth in developing zebrafish exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and reduced hedgehog expression. Aquat Toxicol 78: 103-13 PubMed GONUTS page
↑ ^39.0 ^39.1 Eberhart JK et al. (2006) Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial development. Development 133: 1069-77 PubMed GONUTS page
↑ Osborn DP et al. (2011) Cdkn1c drives muscle differentiation through a positive feedback loop with Myod. Dev Biol 350: 464-75 PubMed GONUTS page
↑ Yin A et al. (2011) Wnt signaling is required for early development of zebrafish swimbladder. PLoS One 6: e18431 PubMed GONUTS page
↑ Winata CL et al. (2009) Development of zebrafish swimbladder: The requirement of Hedgehog signaling in specification and organization of the three tissue layers. Dev Biol 331: 222-36 PubMed GONUTS page
↑ ^43.0 ^43.1 Barresi MJ et al. (2000) The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity. Development 127: 2189-99 PubMed GONUTS page
↑ Take-uchi M et al. (2003) Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activity. Development 130: 955-68 PubMed GONUTS page
↑ Aanstad P et al. (2009) The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling. Curr Biol 19: 1034-9 PubMed GONUTS page

[PMID:18377889-0] Pendeville H et al. (2008) Zebrafish Sox7 and Sox18 function together to control arterial-venous identity. Dev Biol 317: 405-16 PubMed GONUTS page

[PMID:16502420-1] 2.0 ^2.1 ^2.2 Takamiya M & Campos-Ortega JA (2006) Hedgehog signalling controls zebrafish neural keel morphogenesis via its level-dependent effects on neurogenesis. Dev Dyn 235: 978-97 PubMed GONUTS page

[PMID:21558385-2] 3.0 ^3.1 ^3.2 Hami D et al. (2011) Zebrafish cardiac development requires a conserved secondary heart field. Development 138: 2389-98 PubMed GONUTS page

[PMID:16136078-3] 4.0 ^4.1 Corbit KC et al. (2005) Vertebrate Smoothened functions at the primary cilium. Nature 437: 1018-21 PubMed GONUTS page

[PMID:11493557-4] 5.0 ^5.1 ^5.2 ^5.3 Chen W et al. (2001) Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity. Development 128: 2385-96 PubMed GONUTS page

[PMID:11566855-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Varga ZM et al. (2001) Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development 128: 3497-509 PubMed GONUTS page

[PMID:13129844-6] Ungos JM et al. (2003) Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons. Development 130: 5351-62 PubMed GONUTS page

[PMID:19846707-7] Paulus JD et al. (2009) Muscle contractions guide rohon-beard peripheral sensory axons. J Neurosci 29: 13190-201 PubMed GONUTS page

[PMID:20806318-8] 9.0 ^9.1 ^9.2 Barresi MJ et al. (2010) Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Dev Dyn 239: 2603-18 PubMed GONUTS page

[PMID:15618520-9] Wilbanks AM et al. (2004) Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. Science 306: 2264-7 PubMed GONUTS page

[PMID:17046741-10] Feng X et al. (2006) Hedgehog acts directly on the zebrafish dermomyotome to promote myogenic differentiation. Dev Biol 300: 736-46 PubMed GONUTS page

[PMID:12889061-11] Tallafuss A et al. (2003) Selective control of neuronal cluster size at the forebrain/midbrain boundary by signaling from the prechordal plate. Dev Dyn 227: 524-35 PubMed GONUTS page

[PMID:12588855-12] 13.0 ^13.1 Hammond KL et al. (2003) Hedgehog signalling is required for correct anteroposterior patterning of the zebrafish otic vesicle. Development 130: 1403-17 PubMed GONUTS page

[PMID:18842815-13] Thomas NA et al. (2008) Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential. Development 135: 3789-99 PubMed GONUTS page

[PMID:12167410-14] 15.0 ^15.1 Park HC et al. (2002) olig2 is required for zebrafish primary motor neuron and oligodendrocyte development. Dev Biol 248: 356-68 PubMed GONUTS page

[PMID:12508225-15] Albert S et al. (2003) Cyclops-independent floor plate differentiation in zebrafish embryos. Dev Dyn 226: 59-66 PubMed GONUTS page

[PMID:18358464-16] Sanek NA & Grinblat Y (2008) A novel role for zebrafish zic2a during forebrain development. Dev Biol 317: 325-35 PubMed GONUTS page

[PMID:11239427-17] Rohr KB et al. (2001) The nodal pathway acts upstream of hedgehog signaling to specify ventral telencephalic identity. Neuron 29: 341-51 PubMed GONUTS page

[PMID:18423594-18] McFarland KA et al. (2008) Hh and Wnt signaling regulate formation of olig2+ neurons in the zebrafish cerebellum. Dev Biol 318: 162-71 PubMed GONUTS page

[PMID:12606279-19] Sbrogna JL et al. (2003) Multiple roles for Hedgehog signaling in zebrafish pituitary development. Dev Biol 254: 19-35 PubMed GONUTS page

[PMID:18060804-20] Ke Z et al. (2008) Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment. Mol Cell Neurosci 37: 388-401 PubMed GONUTS page

[PMID:15572133-21] Henry CA & Amacher SL (2004) Zebrafish slow muscle cell migration induces a wave of fast muscle morphogenesis. Dev Cell 7: 917-23 PubMed GONUTS page

[PMID:15533825-22] Cheesman SE & Eisen JS (2004) gsh1 demarcates hypothalamus and intermediate spinal cord in zebrafish. Gene Expr Patterns 5: 107-12 PubMed GONUTS page

[PMID:15281067-23] Teraoka H et al. (2004) Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos. J Neurobiol 60: 275-88 PubMed GONUTS page

[PMID:11553330-24] Roy S et al. (2001) Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo. Curr Biol 11: 1358-63 PubMed GONUTS page

[PMID:16055112-25] Mavropoulos A et al. (2005) sox4b is a key player of pancreatic alpha cell differentiation in zebrafish. Dev Biol 285: 211-23 PubMed GONUTS page

[PMID:16490192-26] Wan H et al. (2006) Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter. Exp Cell Res 312: 1526-39 PubMed GONUTS page

[PMID:11900460-27] Iorio PJ et al. (2002) Sonic hedgehog is required early in pancreatic islet development. Dev Biol 244: 75-84 PubMed GONUTS page

[PMID:18410733-28] Chung WS & Stainier DY (2008) Intra-endodermal interactions are required for pancreatic beta cell induction. Dev Cell 14: 582-93 PubMed GONUTS page

[PMID:15857917-29] Kay JN et al. (2005) Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina. Development 132: 2573-85 PubMed GONUTS page

[PMID:17574823-30] 31.0 ^31.1 ^31.2 Schibler A & Malicki J (2007) A screen for genetic defects of the zebrafish ear. Mech Dev 124: 592-604 PubMed GONUTS page

[PMID:17597528-31] Hadzhiev Y et al. (2007) Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish. BMC Dev Biol 7: 75 PubMed GONUTS page

[PMID:15728669-32] Dutta S et al. (2005) pitx3 defines an equivalence domain for lens and anterior pituitary placode. Development 132: 1579-90 PubMed GONUTS page

[PMID:20193674-33] 34.0 ^34.1 ^34.2 Williams C et al. (2010) Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate. Dev Biol 341: 196-204 PubMed GONUTS page

[PMID:15464578-34] Hirsinger E et al. (2004) Hedgehog signaling is required for commitment but not initial induction of slow muscle precursors. Dev Biol 275: 143-57 PubMed GONUTS page

[PMID:19123126-35] Parkin CA et al. (2009) Hedgehog signalling is required for cloacal development in the zebrafish embryo. Int J Dev Biol 53: 45-57 PubMed GONUTS page

[PMID:16049113-36] Wada N et al. (2005) Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull. Development 132: 3977-88 PubMed GONUTS page

[PMID:16580747-37] Teraoka H et al. (2006) Impairment of lower jaw growth in developing zebrafish exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and reduced hedgehog expression. Aquat Toxicol 78: 103-13 PubMed GONUTS page

[PMID:16481351-38] 39.0 ^39.1 Eberhart JK et al. (2006) Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial development. Development 133: 1069-77 PubMed GONUTS page

[PMID:21147088-39] Osborn DP et al. (2011) Cdkn1c drives muscle differentiation through a positive feedback loop with Myod. Dev Biol 350: 464-75 PubMed GONUTS page

[PMID:21479192-40] Yin A et al. (2011) Wnt signaling is required for early development of zebrafish swimbladder. PLoS One 6: e18431 PubMed GONUTS page

[PMID:19422819-41] Winata CL et al. (2009) Development of zebrafish swimbladder: The requirement of Hedgehog signaling in specification and organization of the three tissue layers. Dev Biol 331: 222-36 PubMed GONUTS page

[PMID:10769242-42] 43.0 ^43.1 Barresi MJ et al. (2000) The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity. Development 127: 2189-99 PubMed GONUTS page

[PMID:12538521-43] Take-uchi M et al. (2003) Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activity. Development 130: 955-68 PubMed GONUTS page

[PMID:19464178-44] Aanstad P et al. (2009) The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling. Curr Biol 19: 1034-9 PubMed GONUTS page

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Species (Taxon ID)	Danio rerio (zebrafish) (taxon:7955)
Gene Name(s)	smo
Protein Name(s)	smoothened homolog (Drosophila),
External Links
ZFIN	ZDB-GENE-980526-89

ZFIN:smo

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