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ZFIN:scube2

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Contents

Species (Taxon ID) Danio rerio (zebrafish) (taxon:7955)
Gene Name(s) scube2
Protein Name(s) signal peptide, CUB domain, EGF-like 2,
External Links
ZFIN ZDB-GENE-050302-80

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001756

somitogenesis

ZFIN:ZDB-PUB-060424-5
PMID:16626681[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1089

P

From ZFIN

GO:0001756

somitogenesis

ZFIN:ZDB-PUB-060424-5
PMID:16626681[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1089
ZFIN:ZDB-GENO-980202-1517

P

From ZFIN

GO:0001756

somitogenesis

ZFIN:ZDB-PUB-060424-5
PMID:16626681[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1517

P

From ZFIN

GO:0005509

calcium ion binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001881

F

From ZFIN

GO:0005509

calcium ion binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR018097

F

From ZFIN

GO:0005576

extracellular region

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0964

C

From ZFIN

GO:0005576

extracellular region

ZFIN:ZDB-PUB-060424-5
PMID:16626681[1]

IDA: Inferred from Direct Assay

C

From ZFIN

GO:0005615

extracellular space

ZFIN:ZDB-PUB-050125-7
PMID:15660164[2]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q8IWY4

C

From ZFIN

GO:0007224

smoothened signaling pathway

ZFIN:ZDB-PUB-050125-7
PMID:15660164[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1517

P

From ZFIN

GO:0007224

smoothened signaling pathway

ZFIN:ZDB-PUB-060424-5
PMID:16626681[1]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-050209-30
ZFIN:ZDB-GENO-980202-1517

P

From ZFIN

GO:0007224

smoothened signaling pathway

ZFIN:ZDB-PUB-060424-5
PMID:16626681[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1517

P

From ZFIN

GO:0007517

muscle organ development

ZFIN:ZDB-PUB-050125-7
PMID:15660164[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1517

P

From ZFIN

GO:0008015

blood circulation

ZFIN:ZDB-PUB-970210-25
PMID:9007249[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070808-24

P

From ZFIN

GO:0008015

blood circulation

ZFIN:ZDB-PUB-970210-25
PMID:9007249[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070808-35

P

From ZFIN

GO:0008015

blood circulation

ZFIN:ZDB-PUB-970210-25
PMID:9007249[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070808-38

P

From ZFIN

GO:0009897

external side of plasma membrane

ZFIN:ZDB-PUB-050125-7
PMID:15660164[2]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q8IWY4

C

From ZFIN

GO:0009986

cell surface

ZFIN:ZDB-PUB-050309-4
PMID:15753045[4]

IDA: Inferred from Direct Assay

C

From ZFIN

GO:0030141

secretory granule

ZFIN:ZDB-PUB-050309-4
PMID:15753045[4]

IDA: Inferred from Direct Assay

C

From ZFIN

GO:0030514

negative regulation of BMP signaling pathway

ZFIN:ZDB-PUB-050309-4
PMID:15753045[4]

IGI: Inferred from Genetic Interaction

P

From ZFIN

GO:0042694

muscle cell fate specification

ZFIN:ZDB-PUB-991216-1
PMID:10642786[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1517

P

From ZFIN

GO:0051146

striated muscle cell differentiation

ZFIN:ZDB-PUB-060424-5
PMID:16626681[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1517

P

From ZFIN


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Hollway GE et al. (2006) Scube2 mediates Hedgehog signalling in the zebrafish embryo. Dev Biol 294: 104-18 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Woods IG & Talbot WS (2005) The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish. PLoS Biol 3: e66 PubMed GONUTS page
  3. 3.0 3.1 3.2 Chen JN et al. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development 123: 293-302 PubMed GONUTS page
  4. 4.0 4.1 4.2 Kawakami A et al. (2005) The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling. Curr Biol 15: 480-8 PubMed GONUTS page
  5. Lewis KE et al. (1999) Control of muscle cell-type specification in the zebrafish embryo by Hedgehog signalling. Dev Biol 216: 469-80 PubMed GONUTS page
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