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ZFIN:runx1

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Contents

Species (Taxon ID) Danio rerio (zebrafish) (taxon:7955)
Gene Name(s) runx1
Protein Name(s) runt-related transcription factor 1,
External Links
ZFIN ZDB-GENE-000605-1

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001568

blood vessel development

ZFIN:ZDB-PUB-020410-3
PMID:11934867[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060207-1

P

From ZFIN

GO:0001568

blood vessel development

ZFIN:ZDB-PUB-020410-3
PMID:11934867[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060207-2

P

From ZFIN

GO:0003677

DNA binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000040

F

From ZFIN

GO:0003677

DNA binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR012346

F

From ZFIN

GO:0003677

DNA binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR013524

F

From ZFIN

GO:0003700

sequence-specific DNA binding transcription factor activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR008967

F

From ZFIN

GO:0003700

sequence-specific DNA binding transcription factor activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR012346

F

From ZFIN

GO:0003700

sequence-specific DNA binding transcription factor activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR013524

F

From ZFIN

GO:0005524

ATP binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000040

F

From ZFIN

GO:0005634

nucleus

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000040

C

From ZFIN

GO:0005634

nucleus

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR012346

C

From ZFIN

GO:0006355

regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000040

P

From ZFIN

GO:0006355

regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR008967

P

From ZFIN

GO:0006355

regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR012346

P

From ZFIN

GO:0006355

regulation of transcription, DNA-dependent

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR013524

P

From ZFIN

GO:0007399

nervous system development

ZFIN:ZDB-PUB-020410-3
PMID:11934867[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060207-1

P

From ZFIN

GO:0007399

nervous system development

ZFIN:ZDB-PUB-020410-3
PMID:11934867[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060207-2

P

From ZFIN

GO:0010628

positive regulation of gene expression

ZFIN:ZDB-PUB-090318-8
PMID:19275935[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-010611-1
ZFIN:ZDB-GENE-980526-164

P

From ZFIN

GO:0010628

positive regulation of gene expression

ZFIN:ZDB-PUB-090318-8
PMID:19275935[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060207-1

P

From ZFIN

GO:0030097

hemopoiesis

ZFIN:ZDB-PUB-050303-2
PMID:15737934[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050726-3

P

From ZFIN

GO:0030097

hemopoiesis

ZFIN:ZDB-PUB-070625-20
PMID:17559829[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050726-3

P

From ZFIN

GO:0030097

hemopoiesis

ZFIN:ZDB-PUB-100223-24
PMID:20154212[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-091020-2

P

From ZFIN

GO:0030099

myeloid cell differentiation

ZFIN:ZDB-PUB-090318-8
PMID:19275935[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060207-1

P

From ZFIN

GO:0030099

myeloid cell differentiation

ZFIN:ZDB-PUB-111205-10
PMID:22132109[6]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-120220-7

P

From ZFIN

GO:0035162

embryonic hemopoiesis

ZFIN:ZDB-PUB-020410-3
PMID:11934867[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060207-2

P

From ZFIN

GO:0035162

embryonic hemopoiesis

ZFIN:ZDB-PUB-050920-8
PMID:16166372[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051102-3
ZFIN:ZDB-MRPHLNO-051102-4

P

From ZFIN

GO:0043565

sequence-specific DNA binding

ZFIN:ZDB-PUB-090318-8
PMID:19275935[2]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-020515-2

F

From ZFIN

GO:0060216

definitive hemopoiesis

ZFIN:ZDB-PUB-081022-37
PMID:18927441[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-100813-4

P

From ZFIN

GO:0060216

definitive hemopoiesis

ZFIN:ZDB-PUB-090204-17
PMID:19168679[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-091020-2

P

From ZFIN

GO:0060216

definitive hemopoiesis

ZFIN:ZDB-PUB-090204-17
PMID:19168679[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051102-3
ZFIN:ZDB-MRPHLNO-051102-4

P

From ZFIN


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 Kalev-Zylinska ML et al. (2002) Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis. Development 129: 2015-30 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Kitaguchi T et al. (2009) Transcriptional regulation of a myeloid-lineage specific gene lysozyme C during zebrafish myelopoiesis. Mech Dev 126: 314-23 PubMed GONUTS page
  3. Gering M & Patient R (2005) Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos. Dev Cell 8: 389-400 PubMed GONUTS page
  4. Zhang XY & Rodaway AR (2007) SCL-GFP transgenic zebrafish: in vivo imaging of blood and endothelial development and identification of the initial site of definitive hematopoiesis. Dev Biol 307: 179-94 PubMed GONUTS page
  5. Sood R et al. (2010) Development of multilineage adult hematopoiesis in the zebrafish with a runx1 truncation mutation. Blood 115: 2806-9 PubMed GONUTS page
  6. Ma N et al. (2011) Characterization of a weak allele of zebrafish cloche mutant. PLoS One 6: e27540 PubMed GONUTS page
  7. Burns CE et al. (2005) Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev 19: 2331-42 PubMed GONUTS page
  8. Lam EY et al. (2009) Zebrafish runx1 promoter-EGFP transgenics mark discrete sites of definitive blood progenitors. Blood 113: 1241-9 PubMed GONUTS page
  9. 9.0 9.1 Jin H et al. (2009) Definitive hematopoietic stem/progenitor cells manifest distinct differentiation output in the zebrafish VDA and PBI. Development 136: 647-54 PubMed GONUTS page
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