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ZFIN:pkd2
Contents |
| Species (Taxon ID) | Danio rerio (zebrafish) (taxon:7955) | |
| Gene Name(s) | pkd2 | |
| Protein Name(s) | polycystic kidney disease 2, | |
| External Links | ||
| ZFIN | ZDB-GENE-040827-4 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001947 |
heart looping |
ZFIN:ZDB-PUB-080422-5 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-070129-3 |
P |
From ZFIN |
||
| GO:0001947 |
heart looping |
ZFIN:ZDB-PUB-971203-9 |
IMP: Inferred from Mutant Phenotype |
P |
From ZFIN |
|||
| GO:0003143 |
embryonic heart tube morphogenesis |
ZFIN:ZDB-PUB-971203-9 |
IMP: Inferred from Mutant Phenotype |
P |
From ZFIN |
|||
| GO:0003146 |
heart jogging |
ZFIN:ZDB-PUB-971203-9 |
IMP: Inferred from Mutant Phenotype |
P |
From ZFIN |
|||
| GO:0005509 |
calcium ion binding |
ZFIN:ZDB-PUB-020724-1 |
IEA: Inferred from Electronic Annotation |
F |
From ZFIN |
|||
| GO:0005509 |
calcium ion binding |
ZFIN:ZDB-PUB-020724-1 |
IEA: Inferred from Electronic Annotation |
F |
From ZFIN |
|||
| GO:0005783 |
endoplasmic reticulum |
ZFIN:ZDB-PUB-080422-5 |
IDA: Inferred from Direct Assay |
C |
From ZFIN |
|||
| GO:0005929 |
cilium |
ZFIN:ZDB-PUB-080422-5 |
IDA: Inferred from Direct Assay |
C |
From ZFIN |
|||
| GO:0005929 |
cilium |
ZFIN:ZDB-PUB-080826-12 |
IDA: Inferred from Direct Assay |
C |
From ZFIN |
|||
| GO:0007368 |
determination of left/right symmetry |
ZFIN:ZDB-PUB-060906-19 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-070129-2 |
P |
From ZFIN |
||
| GO:0007368 |
determination of left/right symmetry |
ZFIN:ZDB-PUB-070330-10 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-GENO-980202-1193 |
P |
From ZFIN |
||
| GO:0007368 |
determination of left/right symmetry |
ZFIN:ZDB-PUB-070330-10 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-GENO-980202-870 |
P |
From ZFIN |
||
| GO:0007368 |
determination of left/right symmetry |
ZFIN:ZDB-PUB-070330-10 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-070620-5 |
P |
From ZFIN |
||
| GO:0007368 |
determination of left/right symmetry |
ZFIN:ZDB-PUB-070330-10 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-070620-6 |
P |
From ZFIN |
||
| GO:0007368 |
determination of left/right symmetry |
ZFIN:ZDB-PUB-080422-5 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-070129-3 |
P |
From ZFIN |
||
| GO:0007368 |
determination of left/right symmetry |
ZFIN:ZDB-PUB-100223-49 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-060630-4 |
P |
From ZFIN |
||
| GO:0007368 |
determination of left/right symmetry |
ZFIN:ZDB-PUB-110517-8 |
IGI: Inferred from Genetic Interaction |
ZFIN:ZDB-MRPHLNO-060630-4 |
P |
From ZFIN |
||
| GO:0007368 |
determination of left/right symmetry |
ZFIN:ZDB-PUB-971203-9 |
IMP: Inferred from Mutant Phenotype |
P |
From ZFIN |
|||
| GO:0009953 |
dorsal/ventral pattern formation |
ZFIN:ZDB-PUB-090616-13 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-060630-4 |
P |
From ZFIN |
||
| GO:0016020 |
membrane |
ZFIN:ZDB-PUB-020724-1 |
IEA: Inferred from Electronic Annotation |
C |
From ZFIN |
|||
| GO:0016323 |
basolateral plasma membrane |
ZFIN:ZDB-PUB-080422-5 |
IDA: Inferred from Direct Assay |
C |
From ZFIN |
|||
| GO:0016323 |
basolateral plasma membrane |
ZFIN:ZDB-PUB-080826-12 |
IDA: Inferred from Direct Assay |
C |
From ZFIN |
|||
| GO:0016328 |
lateral plasma membrane |
ZFIN:ZDB-PUB-060323-31 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From ZFIN |
|||
| GO:0032965 |
regulation of collagen biosynthetic process |
ZFIN:ZDB-PUB-100330-18 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-070129-4 |
P |
From ZFIN |
||
| GO:0048793 |
pronephros development |
ZFIN:ZDB-PUB-060906-19 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-070129-2 |
P |
From ZFIN |
||
| GO:0048793 |
pronephros development |
ZFIN:ZDB-PUB-080422-5 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-070129-3 |
P |
From ZFIN |
||
| GO:0048793 |
pronephros development |
ZFIN:ZDB-PUB-080826-10 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-070129-2 |
P |
From ZFIN |
||
| GO:0048793 |
pronephros development |
ZFIN:ZDB-PUB-091023-19 |
IGI: Inferred from Genetic Interaction |
ZFIN:ZDB-GENE-040426-770 |
P |
From ZFIN |
||
| GO:0048793 |
pronephros development |
ZFIN:ZDB-PUB-100826-13 |
IGI: Inferred from Genetic Interaction |
ZFIN:ZDB-MRPHLNO-060630-4 |
P |
From ZFIN |
||
| GO:0048793 |
pronephros development |
ZFIN:ZDB-PUB-110719-12 |
IGI: Inferred from Genetic Interaction |
ZFIN:ZDB-MRPHLNO-060630-4 |
P |
From ZFIN |
||
| GO:0048793 |
pronephros development |
ZFIN:ZDB-PUB-110719-12 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-060630-4 |
P |
From ZFIN |
||
| GO:0072019 |
proximal convoluted tubule development |
ZFIN:ZDB-PUB-090112-10 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-070129-4 |
P |
From ZFIN |
||
| GO:0072114 |
pronephros morphogenesis |
ZFIN:ZDB-PUB-100223-49 |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-060630-4 |
P |
From ZFIN |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Fu X et al. (2008) The subcellular localization of TRPP2 modulates its function. J Am Soc Nephrol 19: 1342-51 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Chen JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124: 4373-82 PubMed GONUTS page
- ↑ 3.0 3.1 Feng S et al. (2008) Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2. J Biol Chem 283: 28471-9 PubMed GONUTS page
- ↑ 4.0 4.1 Obara T et al. (2006) Polycystin-2 immunolocalization and function in zebrafish. J Am Soc Nephrol 17: 2706-18 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Schottenfeld J et al. (2007) Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpaw. Development 134: 1605-15 PubMed GONUTS page
- ↑ 6.0 6.1 Giamarchi A et al. (2010) A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J 29: 1176-91 PubMed GONUTS page
- ↑ Fogelgren B et al. (2011) The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes. PLoS Genet 7: e1001361 PubMed GONUTS page
- ↑ Yuan S & Sun Z (2009) Microinjection of mRNA and morpholino antisense oligonucleotides in zebrafish embryos. J Vis Exp PubMed GONUTS page
- ↑ Streets AJ et al. (2006) Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro. Hum Mol Genet 15: 1465-73 PubMed GONUTS page
- ↑ Mangos S et al. (2010) The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation. Dis Model Mech 3: 354-65 PubMed GONUTS page
- ↑ Köttgen M et al. (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol 182: 437-47 PubMed GONUTS page
- ↑ Gao H et al. (2010) PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation. Hum Mol Genet 19: 16-24 PubMed GONUTS page
- ↑ Hurd T et al. (2010) The retinitis pigmentosa protein RP2 interacts with polycystin 2 and regulates cilia-mediated vertebrate development. Hum Mol Genet 19: 4330-44 PubMed GONUTS page
- ↑ 14.0 14.1 Rothschild SC et al. (2011) CaMK-II is a PKD2 target that promotes pronephric kidney development and stabilizes cilia. Development 138: 3387-97 PubMed GONUTS page
- ↑ Vasilyev A et al. (2009) Collective cell migration drives morphogenesis of the kidney nephron. PLoS Biol 7: e9 PubMed GONUTS page
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