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ZFIN:mib

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Contents

Species (Taxon ID) Danio rerio (zebrafish) (taxon:7955)
Gene Name(s) mib
Protein Name(s) mind bomb,
External Links
ZFIN ZDB-GENE-030404-2

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000151

ubiquitin ligase complex

ZFIN:ZDB-PUB-040312-3
PMID:15013799[1]

IC: Inferred by Curator

GO:0004842

C

From ZFIN

GO:0000151

ubiquitin ligase complex

ZFIN:ZDB-PUB-070122-12
PMID:17196985[2]

IC: Inferred by Curator

GO:0004842

C

From ZFIN

GO:0001568

blood vessel development

ZFIN:ZDB-PUB-070210-29
PMID:17251261[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-050209-22

P

From ZFIN

GO:0001570

vasculogenesis

ZFIN:ZDB-PUB-080408-9
PMID:18377889[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0001756

somitogenesis

ZFIN:ZDB-PUB-051019-8
PMID:16225858[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0001756

somitogenesis

ZFIN:ZDB-PUB-070303-40
PMID:17331493[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070730-1

P

From ZFIN

GO:0001756

somitogenesis

ZFIN:ZDB-PUB-070303-40
PMID:17331493[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070730-2

P

From ZFIN

GO:0001756

somitogenesis

ZFIN:ZDB-PUB-070303-40
PMID:17331493[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0001756

somitogenesis

ZFIN:ZDB-PUB-970210-13
PMID:9007237[7]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0001885

endothelial cell development

ZFIN:ZDB-PUB-070210-29
PMID:17251261[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-050209-22

P

From ZFIN

GO:0002064

epithelial cell development

ZFIN:ZDB-PUB-090828-23
PMID:19705151[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070730-2

P

From ZFIN

GO:0002064

epithelial cell development

ZFIN:ZDB-PUB-090828-23
PMID:19705151[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0002090

regulation of receptor internalization

ZFIN:ZDB-PUB-070122-12
PMID:17196985[2]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0004842

ubiquitin-protein ligase activity

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR010606

F

From ZFIN

GO:0004842

ubiquitin-protein ligase activity

ZFIN:ZDB-PUB-040312-3
PMID:15013799[1]

IDA: Inferred from Direct Assay

F

From ZFIN

GO:0005515

protein binding

ZFIN:ZDB-PUB-040312-3
PMID:15013799[1]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-980526-29

F

From ZFIN

GO:0005515

protein binding

ZFIN:ZDB-PUB-040312-3
PMID:15013799[1]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-990415-47

F

From ZFIN

GO:0005515

protein binding

ZFIN:ZDB-PUB-070122-12
PMID:17196985[2]

IPI: Inferred from Physical Interaction

RefSeq:NP_571019

F

From ZFIN

GO:0005515

protein binding

ZFIN:ZDB-PUB-070122-12
PMID:17196985[2]

IPI: Inferred from Physical Interaction

RefSeq:NP_571029

F

From ZFIN

GO:0005515

protein binding

ZFIN:ZDB-PUB-070122-12
PMID:17196985[2]

IPI: Inferred from Physical Interaction

RefSeq:NP_571030

F

From ZFIN

GO:0005515

protein binding

ZFIN:ZDB-PUB-070122-12
PMID:17196985[2]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-050628-1

F

From ZFIN

GO:0005737

cytoplasm

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

From ZFIN

GO:0005737

cytoplasm

ZFIN:ZDB-PUB-040312-3
PMID:15013799[1]

IDA: Inferred from Direct Assay

C

From ZFIN

GO:0005737

cytoplasm

ZFIN:ZDB-PUB-070122-12
PMID:17196985[2]

IDA: Inferred from Direct Assay

C

From ZFIN

GO:0005737

cytoplasm

ZFIN:ZDB-PUB-120306-2

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

From ZFIN

GO:0005886

plasma membrane

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

From ZFIN

GO:0005886

plasma membrane

ZFIN:ZDB-PUB-120306-2

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

From ZFIN

GO:0007219

Notch signaling pathway

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0914

P

From ZFIN

GO:0007219

Notch signaling pathway

ZFIN:ZDB-PUB-050202-2
PMID:15680358[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0007219

Notch signaling pathway

ZFIN:ZDB-PUB-070212-38
PMID:17287248[10]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-199

P

From ZFIN

GO:0007275

multicellular organismal development

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

From ZFIN

GO:0007368

determination of left/right symmetry

ZFIN:ZDB-PUB-070122-14
PMID:17199043[11]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0008270

zinc ion binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR000433

F

From ZFIN

GO:0008270

zinc ion binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR001841

F

From ZFIN

GO:0008284

positive regulation of cell proliferation

ZFIN:ZDB-PUB-050610-14
PMID:15944187[12]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-050811-1
ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0009880

embryonic pattern specification

ZFIN:ZDB-PUB-040916-2
PMID:15366005[13]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0010001

glial cell differentiation

ZFIN:ZDB-PUB-040312-3
PMID:15013799[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020426-41

P

From ZFIN

GO:0016020

membrane

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From ZFIN

GO:0016567

protein ubiquitination

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR010606

P

From ZFIN

GO:0016567

protein ubiquitination

ZFIN:ZDB-PUB-040312-3
PMID:15013799[1]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0016567

protein ubiquitination

ZFIN:ZDB-PUB-070122-12
PMID:17196985[2]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0016874

ligase activity

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0436

F

From ZFIN

GO:0021508

floor plate formation

ZFIN:ZDB-PUB-061020-47
PMID:17045256[14]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1208

P

From ZFIN

GO:0021514

ventral spinal cord interneuron differentiation

ZFIN:ZDB-PUB-080825-21
PMID:18680739[15]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0021519

spinal cord association neuron specification

ZFIN:ZDB-PUB-070504-3
PMID:17442701[16]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-071004-2

P

From ZFIN

GO:0021520

spinal cord motor neuron cell fate specification

ZFIN:ZDB-PUB-070504-3
PMID:17442701[16]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-071004-2

P

From ZFIN

GO:0021521

ventral spinal cord interneuron specification

ZFIN:ZDB-PUB-061020-47
PMID:17045256[14]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0021654

rhombomere boundary formation

ZFIN:ZDB-PUB-090828-23
PMID:19705151[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070730-2

P

From ZFIN

GO:0021654

rhombomere boundary formation

ZFIN:ZDB-PUB-090828-23
PMID:19705151[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0021986

habenula development

ZFIN:ZDB-PUB-070122-14
PMID:17199043[11]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0030097

hemopoiesis

ZFIN:ZDB-PUB-050920-8
PMID:16166372[17]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-051121-1

P

From ZFIN

GO:0030139

endocytic vesicle

ZFIN:ZDB-PUB-040312-3
PMID:15013799[1]

IDA: Inferred from Direct Assay

C

From ZFIN

GO:0030182

neuron differentiation

ZFIN:ZDB-PUB-040312-3
PMID:15013799[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020426-41

P

From ZFIN

GO:0030318

melanocyte differentiation

ZFIN:ZDB-PUB-070303-40
PMID:17331493[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070730-1

P

From ZFIN

GO:0030318

melanocyte differentiation

ZFIN:ZDB-PUB-070303-40
PMID:17331493[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070730-2

P

From ZFIN

GO:0030318

melanocyte differentiation

ZFIN:ZDB-PUB-070303-40
PMID:17331493[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0030902

hindbrain development

ZFIN:ZDB-PUB-090828-23
PMID:19705151[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070730-2

P

From ZFIN

GO:0030902

hindbrain development

ZFIN:ZDB-PUB-090828-23
PMID:19705151[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0031076

embryonic camera-type eye development

ZFIN:ZDB-PUB-050202-2
PMID:15680358[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0031410

cytoplasmic vesicle

ZFIN:ZDB-PUB-070303-40
PMID:17331493[6]

IDA: Inferred from Direct Assay

C

From ZFIN

GO:0042803

protein homodimerization activity

ZFIN:ZDB-PUB-070122-12
PMID:17196985[2]

IDA: Inferred from Direct Assay

F

From ZFIN

GO:0043234

protein complex

ZFIN:ZDB-PUB-110131-12
PMID:21262462[18]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-030616-450

C

From ZFIN

GO:0045664

regulation of neuron differentiation

ZFIN:ZDB-PUB-040408-2
PMID:15068793[19]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0045685

regulation of glial cell differentiation

ZFIN:ZDB-PUB-050202-2
PMID:15680358[9]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0045747

positive regulation of Notch signaling pathway

ZFIN:ZDB-PUB-040312-3
PMID:15013799[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-020426-41

P

From ZFIN

GO:0045747

positive regulation of Notch signaling pathway

ZFIN:ZDB-PUB-070813-19
PMID:17685488[20]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-071218-1

P

From ZFIN

GO:0046872

metal ion binding

ZFIN:ZDB-PUB-020723-1

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From ZFIN

GO:0046872

metal ion binding

ZFIN:ZDB-PUB-020724-1

IEA: Inferred from Electronic Annotation

InterPro:IPR010606

F

From ZFIN

GO:0048259

regulation of receptor-mediated endocytosis

ZFIN:ZDB-PUB-081217-11
PMID:19056830[21]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-090924-1

P

From ZFIN

GO:0048259

regulation of receptor-mediated endocytosis

ZFIN:ZDB-PUB-081217-11
PMID:19056830[21]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0048471

perinuclear region of cytoplasm

ZFIN:ZDB-PUB-070122-12
PMID:17196985[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-000125-4

C

From ZFIN

GO:0048471

perinuclear region of cytoplasm

ZFIN:ZDB-PUB-070122-12
PMID:17196985[2]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-990415-47

C

From ZFIN

GO:0048514

blood vessel morphogenesis

ZFIN:ZDB-PUB-011010-4
PMID:11585794[22]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0048546

digestive tract morphogenesis

ZFIN:ZDB-PUB-050209-3
PMID:15689380[23]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0048699

generation of neurons

ZFIN:ZDB-PUB-070122-14
PMID:17199043[11]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0048793

pronephros development

ZFIN:ZDB-PUB-070212-38
PMID:17287248[10]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-199

P

From ZFIN

GO:0051865

protein autoubiquitination

ZFIN:ZDB-PUB-070122-12
PMID:17196985[2]

IDA: Inferred from Direct Assay

P

From ZFIN

GO:0051865

protein autoubiquitination

ZFIN:ZDB-PUB-070122-12
PMID:17196985[2]

IMP: Inferred from Mutant Phenotype

P

From ZFIN

GO:0060113

inner ear receptor cell differentiation

ZFIN:ZDB-PUB-000201-15
PMID:10572043[24]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-980202-1107

P

From ZFIN

GO:0060218

hemopoietic stem cell differentiation

ZFIN:ZDB-PUB-090407-3
PMID:19332767[25]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-090730-4

P

From ZFIN

GO:0071599

otic vesicle development

ZFIN:ZDB-PUB-970210-23
PMID:9007247[26]

IMP: Inferred from Mutant Phenotype

P

From ZFIN

contributes_to

GO:0004842

ubiquitin-protein ligase activity

ZFIN:ZDB-PUB-070122-12
PMID:17196985[2]

IDA: Inferred from Direct Assay

F

From ZFIN

contributes_to

GO:0004842

ubiquitin-protein ligase activity

ZFIN:ZDB-PUB-070122-12
PMID:17196985[2]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-050628-1

F

From ZFIN


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Chen W & Casey Corliss D (2004) Three modules of zebrafish Mind bomb work cooperatively to promote Delta ubiquitination and endocytosis. Dev Biol 267: 361-73 PubMed GONUTS page
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 Zhang C et al. (2007) Zebrafish Mib and Mib2 are mutual E3 ubiquitin ligases with common and specific delta substrates. J Mol Biol 366: 1115-28 PubMed GONUTS page
  3. ↑ 3.0 3.1 Leslie JD et al. (2007) Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis. Development 134: 839-44 PubMed GONUTS page
  4. ↑ Pendeville H et al. (2008) Zebrafish Sox7 and Sox18 function together to control arterial-venous identity. Dev Biol 317: 405-16 PubMed GONUTS page
  5. ↑ Henry CA et al. (2005) Interactions between muscle fibers and segment boundaries in zebrafish. Dev Biol 287: 346-60 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Zhang C et al. (2007) The characterization of zebrafish antimorphic mib alleles reveals that Mib and Mind bomb-2 (Mib2) function redundantly. Dev Biol 305: 14-27 PubMed GONUTS page
  7. ↑ van Eeden FJ et al. (1996) Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. Development 123: 153-64 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Qiu X et al. (2009) Temporal Notch activation through Notch1a and Notch3 is required for maintaining zebrafish rhombomere boundaries. Dev Genes Evol 219: 339-51 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Bernardos RL et al. (2005) Notch-Delta signaling is required for spatial patterning and Müller glia differentiation in the zebrafish retina. Dev Biol 278: 381-95 PubMed GONUTS page
  10. ↑ 10.0 10.1 Liu Y et al. (2007) Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros. Development 134: 1111-22 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 Aizawa H et al. (2007) Temporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures. Dev Cell 12: 87-98 PubMed GONUTS page
  12. ↑ Yamaguchi M et al. (2005) Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and Notch signaling pathways. Development 132: 3027-43 PubMed GONUTS page
  13. ↑ Riley BB et al. (2004) Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain. Dev Dyn 231: 278-91 PubMed GONUTS page
  14. ↑ 14.0 14.1 Schäfer M et al. (2007) Discontinuous organization and specification of the lateral floor plate in zebrafish. Dev Biol 301: 117-29 PubMed GONUTS page
  15. ↑ Batista MF et al. (2008) Zebrafish V2 cells develop into excitatory CiD and Notch signalling dependent inhibitory VeLD interneurons. Dev Biol 322: 263-75 PubMed GONUTS page
  16. ↑ 16.0 16.1 Shin J et al. (2007) Notch signaling regulates neural precursor allocation and binary neuronal fate decisions in zebrafish. Development 134: 1911-20 PubMed GONUTS page
  17. ↑ Burns CE et al. (2005) Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev 19: 2331-42 PubMed GONUTS page
  18. ↑ Ohata S et al. (2011) Dual roles of Notch in regulation of apically restricted mitosis and apicobasal polarity of neuroepithelial cells. Neuron 69: 215-30 PubMed GONUTS page
  19. ↑ Cheng YC et al. (2004) Notch activation regulates the segregation and differentiation of rhombomere boundary cells in the zebrafish hindbrain. Dev Cell 6: 539-50 PubMed GONUTS page
  20. ↑ Del Monte G et al. (2007) Monitoring Notch1 activity in development: evidence for a feedback regulatory loop. Dev Dyn 236: 2594-614 PubMed GONUTS page
  21. ↑ 21.0 21.1 Matsuda M & Chitnis AB (2009) Interaction with Notch determines endocytosis of specific Delta ligands in zebrafish neural tissue. Development 136: 197-206 PubMed GONUTS page
  22. ↑ Lawson ND et al. (2001) Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development 128: 3675-83 PubMed GONUTS page
  23. ↑ Crosnier C et al. (2005) Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine. Development 132: 1093-104 PubMed GONUTS page
  24. ↑ Riley BB et al. (1999) The deltaA gene of zebrafish mediates lateral inhibition of hair cells in the inner ear and is regulated by pax2.1. Development 126: 5669-78 PubMed GONUTS page
  25. ↑ Burns CE et al. (2009) A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood 113: 5776-82 PubMed GONUTS page
  26. ↑ Malicki J et al. (1996) Mutations affecting development of the zebrafish ear. Development 123: 275-83 PubMed GONUTS page
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