ZFIN:lef1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001569	patterning of blood vessels	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0001649	osteoblast differentiation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0001755	neural crest cell migration	ZFIN:ZDB-PUB-051019-12 PMID:16228014^[1]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-060214-5	P	From ZFIN
	GO:0001756	somitogenesis	ZFIN:ZDB-PUB-090616-54 PMID:19517013^[2]	IMP: Inferred from Mutant Phenotype		P	From ZFIN
	GO:0001837	epithelial to mesenchymal transition	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0002040	sprouting angiogenesis	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0003682	chromatin binding	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN3	F	From ZFIN
	GO:0003700	sequence-specific DNA binding transcription factor activity	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN3	F	From ZFIN
	GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	F	From ZFIN
	GO:0005667	transcription factor complex	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN0	C	From ZFIN
	GO:0005737	cytoplasm	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	C	From ZFIN
	GO:0006355	regulation of transcription, DNA-dependent	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN0	P	From ZFIN
	GO:0006357	regulation of transcription from RNA polymerase II promoter	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN0	P	From ZFIN
	GO:0006917	induction of apoptosis	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0008013	beta-catenin binding	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN0	F	From ZFIN
	GO:0008301	DNA binding, bending	ZFIN:ZDB-PUB-110105-1	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P27782	F	From ZFIN
	GO:0010628	positive regulation of gene expression	ZFIN:ZDB-PUB-091030-2 PMID:18950487^[3]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-060214-6	P	From ZFIN
	GO:0016055	Wnt receptor signaling pathway	ZFIN:ZDB-PUB-020724-1	IEA: Inferred from Electronic Annotation	InterPro:IPR024940	P	From ZFIN
	GO:0016055	Wnt receptor signaling pathway	ZFIN:ZDB-PUB-070601-1 PMID:16890162^[4]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-GENE-990714-26 ZFIN:ZDB-MRPHLNO-071205-3	P	From ZFIN
	GO:0016055	Wnt receptor signaling pathway	ZFIN:ZDB-PUB-111007-2 PMID:21862557^[5]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-100125-1	P	From ZFIN
	GO:0016202	regulation of striated muscle tissue development	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0021542	dentate gyrus development	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0021854	hypothalamus development	ZFIN:ZDB-PUB-061020-59 PMID:17050627^[6]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-060214-6	P	From ZFIN
	GO:0021861	forebrain radial glial cell differentiation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0021873	forebrain neuroblast division	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0021879	forebrain neuron differentiation	ZFIN:ZDB-PUB-080922-13 PMID:18799544^[7]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-060214-6	P	From ZFIN
	GO:0021943	formation of radial glial scaffolds	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0022008	neurogenesis	ZFIN:ZDB-PUB-091215-18 PMID:19946145^[8]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-050809-5 ZFIN:ZDB-MRPHLNO-060214-6	P	From ZFIN
	GO:0022008	neurogenesis	ZFIN:ZDB-PUB-091215-18 PMID:19946145^[8]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-050809-5 ZFIN:ZDB-MRPHLNO-100524-11	P	From ZFIN
	GO:0022008	neurogenesis	ZFIN:ZDB-PUB-091215-18 PMID:19946145^[8]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-060214-6 ZFIN:ZDB-MRPHLNO-100524-9	P	From ZFIN
	GO:0022008	neurogenesis	ZFIN:ZDB-PUB-091215-18 PMID:19946145^[8]	IGI: Inferred from Genetic Interaction	ZFIN:ZDB-MRPHLNO-100524-11 ZFIN:ZDB-MRPHLNO-100524-9	P	From ZFIN
	GO:0022407	regulation of cell-cell adhesion	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0030223	neutrophil differentiation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0030326	embryonic limb morphogenesis	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0030331	estrogen receptor binding	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	F	From ZFIN
	GO:0030509	BMP signaling pathway	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0030520	intracellular estrogen receptor signaling pathway	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0030879	mammary gland development	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0031101	fin regeneration	ZFIN:ZDB-PUB-081121-22 PMID:19015519^[9]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-MRPHLNO-060214-5	P	From ZFIN
	GO:0032696	negative regulation of interleukin-13 production	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0032713	negative regulation of interleukin-4 production	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0032714	negative regulation of interleukin-5 production	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0033333	fin development	ZFIN:ZDB-PUB-111007-2 PMID:21862557^[5]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-111013-9	P	From ZFIN
	GO:0033336	caudal fin development	ZFIN:ZDB-PUB-110901-9 PMID:21862556^[10]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-110922-2	P	From ZFIN
	GO:0033339	pectoral fin development	ZFIN:ZDB-PUB-110901-9 PMID:21862556^[10]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-110922-2	P	From ZFIN
	GO:0035326	enhancer binding	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	F	From ZFIN
	GO:0042100	B cell proliferation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0043565	sequence-specific DNA binding	ZFIN:ZDB-PUB-091030-2 PMID:18950487^[3]	IPI: Inferred from Physical Interaction	ZFIN:ZDB-GENE-041203-2	F	From ZFIN
	GO:0044212	transcription regulatory region DNA binding	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN0	F	From ZFIN
	GO:0045295	gamma-catenin binding	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	F	From ZFIN
	GO:0046632	alpha-beta T cell differentiation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0048069	eye pigmentation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0048341	paraxial mesoderm formation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0048747	muscle fiber development	ZFIN:ZDB-PUB-090616-54 PMID:19517013^[2]	IMP: Inferred from Mutant Phenotype		P	From ZFIN
	GO:0048916	posterior lateral line development	ZFIN:ZDB-PUB-110901-9 PMID:21862556^[10]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-110922-2	P	From ZFIN
	GO:0048916	posterior lateral line development	ZFIN:ZDB-PUB-111007-2 PMID:21862557^[5]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-111013-9	P	From ZFIN
	GO:0048922	posterior lateral line neuromast deposition	ZFIN:ZDB-PUB-110901-9 PMID:21862556^[10]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-110922-2	P	From ZFIN
	GO:0060070	canonical Wnt receptor signaling pathway	ZFIN:ZDB-PUB-020115-2 PMID:11784107^[11]	IMP: Inferred from Mutant Phenotype		P	From ZFIN
	GO:0060325	face morphogenesis	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0060561	apoptotic process involved in morphogenesis	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0060784	regulation of cell proliferation involved in tissue homeostasis	ZFIN:ZDB-PUB-111007-2 PMID:21862557^[5]	IMP: Inferred from Mutant Phenotype	ZFIN:ZDB-GENO-111013-9	P	From ZFIN
	GO:0061153	trachea gland development	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0070016	armadillo repeat domain binding	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	F	From ZFIN
	GO:0071864	positive regulation of cell proliferation in bone marrow	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0071866	negative regulation of apoptotic process in bone marrow	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
	GO:0071895	odontoblast differentiation	ZFIN:ZDB-PUB-110330-1		PANTHER:PTHR10373_AN4	P	From ZFIN
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ishitani T et al. (2005) Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability. Nat Cell Biol 7: 1106-12 PubMed GONUTS page
↑ ^2.0 ^2.1 Tee JM et al. (2009) Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. PLoS One 4: e5880 PubMed GONUTS page
↑ ^3.0 ^3.1 Bonkowsky JL et al. (2008) Domain-specific regulation of foxP2 CNS expression by lef1. BMC Dev Biol 8: 103 PubMed GONUTS page
↑ Xiong B et al. (2006) Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity. Dev Cell 11: 225-38 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Valdivia LE et al. (2011) Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development. Development 138: 3931-41 PubMed GONUTS page
↑ Lee JE et al. (2006) Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis. Development 133: 4451-61 PubMed GONUTS page
↑ Russek-Blum N et al. (2008) Dopaminergic neuronal cluster size is determined during early forebrain patterning. Development 135: 3401-13 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Rai K et al. (2010) Dnmt3 and G9a cooperate for tissue-specific development in zebrafish. J Biol Chem 285: 4110-21 PubMed GONUTS page
↑ Thatcher EJ et al. (2008) Regulation of zebrafish fin regeneration by microRNAs. Proc Natl Acad Sci U S A 105: 18384-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 McGraw HF et al. (2011) Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium. Development 138: 3921-30 PubMed GONUTS page
↑ Dorsky RI et al. (2002) A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development. Dev Biol 241: 229-37 PubMed GONUTS page

[PMID:16228014-0] Ishitani T et al. (2005) Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability. Nat Cell Biol 7: 1106-12 PubMed GONUTS page

[PMID:19517013-1] 2.0 ^2.1 Tee JM et al. (2009) Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. PLoS One 4: e5880 PubMed GONUTS page

[PMID:18950487-2] 3.0 ^3.1 Bonkowsky JL et al. (2008) Domain-specific regulation of foxP2 CNS expression by lef1. BMC Dev Biol 8: 103 PubMed GONUTS page

[PMID:16890162-3] Xiong B et al. (2006) Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity. Dev Cell 11: 225-38 PubMed GONUTS page

[PMID:21862557-4] 5.0 ^5.1 ^5.2 ^5.3 Valdivia LE et al. (2011) Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development. Development 138: 3931-41 PubMed GONUTS page

[PMID:17050627-5] Lee JE et al. (2006) Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis. Development 133: 4451-61 PubMed GONUTS page

[PMID:18799544-6] Russek-Blum N et al. (2008) Dopaminergic neuronal cluster size is determined during early forebrain patterning. Development 135: 3401-13 PubMed GONUTS page

[PMID:19946145-7] 8.0 ^8.1 ^8.2 ^8.3 Rai K et al. (2010) Dnmt3 and G9a cooperate for tissue-specific development in zebrafish. J Biol Chem 285: 4110-21 PubMed GONUTS page

[PMID:19015519-8] Thatcher EJ et al. (2008) Regulation of zebrafish fin regeneration by microRNAs. Proc Natl Acad Sci U S A 105: 18384-9 PubMed GONUTS page

[PMID:21862556-9] 10.0 ^10.1 ^10.2 ^10.3 McGraw HF et al. (2011) Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium. Development 138: 3921-30 PubMed GONUTS page

[PMID:11784107-10] Dorsky RI et al. (2002) A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development. Dev Biol 241: 229-37 PubMed GONUTS page

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Species (Taxon ID)	Danio rerio (zebrafish) (taxon:7955)
Gene Name(s)	lef1
Protein Name(s)	lymphocyte enhancer binding factor 1,
External Links
ZFIN	ZDB-GENE-990714-26

ZFIN:lef1

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